Be Vibrant, Be Vital with Primeadine®

The purest plant-based spermidine supplement, derived from Japan. Slow aging at a cellular level for a healthier, more vibrant you.

Target Aging From Within

Food-derived spermidine mimics the longevity benefits of fasting, activating cell renewal (autophagy) and inhibiting key aging pathways. As we age, our spermidine levels drop, but Primeadine® restores your body's natural balance.

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Read Our Testimonials

Welcome to Your New Prime

As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.

Healthy Aging

Inhibits the root causes of aging, reducing inflammation, regenerating stem cells and mitochondria, and protecting telomeres.

Radiant Wellness

Supports keratin and collagen production and wound healing, reflecting in a radiant glow and healthier hair and nails.

Restore Balance

Harmonizes your circadian rhythm, gut health, and hormones for improved sleep quality, elevated energy levels, and a clearer mind.

Japan Wheat Oxford Healthspan

What is Spermidine?

Spermidine is a natural polyamine that triggers autophagy, the body's cellular cleanup and renewal process, and targets key aging pathways.

In youth, about two-thirds of spermidine is produced by the gut microbiome and body tissues, with the rest coming from food. As we age, natural production declines, making dietary and supplemental sources increasingly essential.

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Recommended by Experts

Dr. Olivia Lesslar

@drolivialesslar

Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Nadine Artemis

@nadineartemisofficial

Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Sandra Kaufmann

@kaufmannantiaging

"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. The products contain not only spermidine, but related polyamines which provide additional health benefits. I highly recommend this product line to all of my patients.

Carol Vorderman

@carolvorders

British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey

@lukestorey

Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj

@magdalenas_secrets

Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima

@dr.stephanie.estima

Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou

@hackmyage

Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam

@nathalieniddam

Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi

@ollisovijarvi

Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

The Primeadine® Difference

All Natural & Plant-Derived

We opt for food-derived spermidine, the safest and most bioavailable form, and ensure our products are free from unhealthy fillers like magnesium stearate. Additionally, we defat our wheat germ to remove potentially rancid PUFAs (polyunsaturated fatty acids).

Sourced in Japan & Rigorously Third Party Tested

Sourced in Japan, home to the world's longest-lived people and strict food standards, Primeadine meets the highest ISO2200 quality control. Rigorous third-party testing in Japan and the USA ensures purity and potency.

Optimal Absorption

Food-derived spermidine is better absorbed than synthetic forms because it comes with naturally co-occurring polyamines that enhance bioavailability. The food matrix effect further improves stability and uptake, while interactions with gut bacteria support metabolism and absorption.

Our Founder: Leslie Kenny

When Leslie was in her late 30's she was diagnosed with a trio of autoimmune diseases, told she had five years to live and that she could give up on having children. Now aged 59, she is autoimmune disease-free, has the biological age of 21, and was able to conceive naturally at 43 despite all odds.

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Learn More on Our Blog

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