Be Vibrant, Be Vital with Primeadine®
The purest plant-based spermidine supplement, derived from Japan. Slow aging at a cellular level for a healthier, more vibrant you.
Target Aging From Within
Food-derived spermidine mimics the longevity benefits of fasting, activating cell renewal (autophagy) and inhibiting key aging pathways. As we age, our spermidine levels drop, but Primeadine® restores your body's natural balance.
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Welcome to Your New Prime
As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.

What is Spermidine?
Spermidine is a natural polyamine that triggers autophagy, the body's cellular cleanup and renewal process, and targets key aging pathways.
In youth, about two-thirds of spermidine is produced by the gut microbiome and body tissues, with the rest coming from food. As we age, natural production declines, making dietary and supplemental sources increasingly essential.
Learn moreRecommended by Experts

@drolivialesslar
Medical Doctor with a Special Interest in Longevity & Complex Conditions
Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It
There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. The products contain not only spermidine, but related polyamines which provide additional health benefits. I highly recommend this product line to all of my patients.

@carolvorders
British TV personality & Biohacker
I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

@lukestorey
Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert
The best spermidine supplement on the market.

@magdalenas_secrets
Biohacker & Anti-Aging Entrepreneur
I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

@hackmyage
Gerontologist, Biohacker & Sports Nutrition Coach
I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

@nathalieniddam
Certified Holistic Health Coach & Biohacker
Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

@silverliberation
Pro-Aging Influencer
One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

@ollisovijarvi
Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center
My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

@emilycahillhealth
Health & Mindset Coach
The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.
The Primeadine® Difference

Our Founder: Leslie Kenny
When Leslie was in her late 30's she was diagnosed with a trio of autoimmune diseases, told she had five years to live and that she could give up on having children. Now aged 59, she is autoimmune disease-free, has the biological age of 21, and was able to conceive naturally at 43 despite all odds.
Read moreLearn More on Our Blog

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