For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.
Introducing our ultimate value pack: 3 bottles of Primeadine Original and 3 bottles of Primeadine GF to take your autophagy and cell renewal to the next level.
You can choose to alternate both products for a 6-month supply, or take both products (GF in the morning and Original in the evening) for a 3-month supply.
Primeadine® is the purest spermidine supplement on the market, with zero fillers or flow agents.
Our formulation provides you with 1mg standardized spermidine, tested in every batch to guarantee you are getting the same amount in every capsule.
To prevent oxidation and the presence of potentially rancid omega 6’s, our wheat germ extract is defatted and, again, tested for purity and potency.
We have also added a special type of maltodextrin that is acting as a prebiotic fiber and resistant starch that will selectively feed the fuso- and Bacteroides bacteria in the gut biome, both of which produce spermidine. The idea behind it is to increase both supplemental, exogenous spermidine as well as your own body's ability to produce endogenous spermidine.
Primeadine GF, our gluten-free, soy-free spermidine supplement exclusively sourced and manufactured in the Longevity islands of Okinawa, is our answer for clients who are Celiac or suffer from Small Intestinal Bacterial Overgrowth (SIBO) or Leaky Gut, or simply want to avoid all sources of gluten in their diets.
Primeadine GF is wholly food-derived with the amount of spermidine, 1mg, that has been used in human clinical trials showing enhancement of memory and cognition.
As a source of polyamines, Primeadine GF contains both spermidine and putrescine, a precursor to spermidine to help your body recycle and manufacture more of its own spermidine.
Spermidine has been shown to keep hair follicles in the growth phase for longer. Typical results include improved hair growth (including eyelashes and eyebrows), stronger hair and nails and more vital, glowing skin
Spermidine improves healthspan by inhibiting 9 of the 12 hallmarks of aging, including stem cell and mitochondrial dysfunction, telomere shortening, inflammation, and gut dysbiosis. Supports memory, cognition, and heart health
Spermidine supports the regulation of your circadian rhythm, assists with deeper, sounder sleep, and can reduce age-associated sleep disruption
Spermidine and its co-occurring polyamines trigger autophagy, your internal cellular "clean up" and renewal process that declines with age. Your cells are the foundation of every organ and tissue in your body; until they are functioning properly, neither is the rest of you
Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.
The effects of spermidine supplements on humans have been studied and have shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.
Epidemiological studies have correlated higher spermidine levels with longer life.
The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.
As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.
Stem cells lose their ability to divide as we age, and we are unable to replace cells that have migrated, differentiated, or died. As a result, we show outward symptoms of aging, such as gray hair.
As cells age, their mitochondria start to lose their integrity due to the build-up of oxidative stress. Compromised mitochondrial function leads to a number of adverse events, such as increased apoptosis induction, that correlate with aging.
Shortened telomeres are associated with aging cells that are senescent. As cells divide, the telomere ends of chromosomes get shorter. Eventually, telomerase gets silenced and the telomeres are too short for cells to divide.
As cells are exposed to environmental factors, they are subject to changes in their genome through epigenetic mechanisms. Such changes accumulate over time and have been correlated with the decline observed in aging cells.
As cells age, they show an increase in self-preserving signals that result in damage elsewhere. Impaired intercellular communication with aging contributes to decline in tissue health.
As cells age, environmental stresses add up and mechanisms responsible for maintaining proper protein composition start to decline. Proteins lose their stability, autophagic processes start to fail, and misfolded proteins accumulate.
Autophagy is an essential process of removing cellular waste products. It is a component of proteostasis, although now a hallmark in its own right since loss of effective autophagy is a key contributor to the decline of organelle turnover and an accelerator of aging.
Microbes living in and on us are now widely understood to be intricately connected to health and disease. In part due to the gradual decline of our immune system’s effectiveness, and since one of our immune system’s roles is in shaping the diversity and species members of our microbiome, our aging microbiomes gradually lose diversity and become altered in their composition.
“Inflammaging” is a term coined to describe the gradual increase of inflammation as we age. It has wide-ranging implications in disease-related activity such as arteriosclerosis, neuroinflammation, osteoarthritis and bone degradation. Inflammation is also clearly linked to all other hallmarks of aging both in its tendency to promote and result from other hallmarks.
