My only supplement I could not live without

It is the only supplement that makes me sleep, look and feel better. The company is first class as well. I have been a long time supporter and will never stop.

— Tim K.

We hope you've enjoyed your Primeadine® sample!

Thank you for taking part in the Latin Grammy's first ever health and wellness event. 

Here's some more of the benefits....

What is Spermidine?

Considered a longevity staple by internationally-recognized scientists, doctors and celebrities, spermidine is a mighty, naturally-occurring polyamine found to increase longevity and healthspan. It tackles the root causes of aging - which include inflammation, gut dysbiosis, and stem cell dysfunction - mainly by activating your body's cellular recycling and "clean up" process called autophagy.

Spermidine is found in all of our cells and is most abudant in sperm (hence the name!), breast milk, and the endosperm of all plants. Early in our lives, we produce it ourselves as well as getting it from our diets. However, our ability to produce it declines with age, making us much more reliant on plant-based, supplemental sources of spermidine, like the healthy centenarians in Japan, which is why we created Primeadine® - so you can replenish your spermidine levels and experience rejuvenation inside and out!

Meet Out Founder

Leslie Kenny

Oxford Healthspan was founded by Leslie Kenny, an Oxford-based, Southern Californian entrepreneur and Berkeley and Harvard Business School graduate. Her life changed dramatically when she was diagnosed with a string of autoimmune diseases - lupus, rheumatoid arthritis and hypothyroidism - in her 30s and told it could only be managed, not cured, with strong immunosuppressants. On a quest to heal herself, she trained at the Institute of Integrative Nutrition in NYC and became a health coach, as well as helping scientists at top-tier European universities find funding for their ground-breaking discoveries. On this exciting career path a little-known age-defying molecule, spermidine, was brought to her attention by a University of Oxford scientist, and the rest is history.

Discovering Japan’s best-kept healthy aging secret…

As well as becoming a certified health coach, Leslie began helping scientists at leading European universities, including the University of Oxford, to raise money for their health discoveries. It was at a meeting with one such scientist that she learned of a natural compound called spermidine, found in a Japanese fermented soybean dish called natto.

Spermidine was showing great promise in supporting healthy aging with its ability to induce autophagy, our body’s cellular renewal process that slows as we age. The science was compelling - scientists were calling it 'an anti-aging vitamin'’ - and it was safe. However, because it was a natural and food-derived compound, not a drug that would bring in more money, no one was interested in promoting it.

What Makes Primeadine® Unique?

100% Plant-Derived

Unlike synthetic and synthetically-enriched spermidine, Primeadine® contains wholly plant-derived spermidine - the only kind to be tested for safety and efficacy in humans - at a minimum effective dose of 1mg. With Primeadine®, it's about quality over quantity.

The Cleanest Ingredients

These days you have to watch out for the hidden nasties not just in your food, but also your supplements! We source and manufacture Primeadine® in Japan, which has one of the strictest food safety protocols in the world, and perform rigorous 3rd party testing so you don't have to worry.

Improves Natural Production

Other beneficial polyamines naturally occur with plant-derived spermidine: spermine, for DNA methylation, and putrescine, a precursor to spermidine and spermine that helps your body make more of both. We also add a special prebiotic fiber to Primeadine® Original that encourages spermidine production in your gut biome.

Trusted by Experts

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

Benefits of Primeadine® Supplements

Healthy Aging

Plant-derived spermidine has been shown to increase longevity and healthspan by addressing the root causes of aging, known as the "Hallmarks of Aging" (including gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction). One of the most important hallmarks it works against is impaired autophagy, or cell renewal, as this effects them all!

Enhanced Cell renewal

Plant-derived spermidine triggers autophagy, your internal cellular recycling and "clean up" process that declines with age. Your cells are foundational to every part of your body; if they're not functioning and regenerating properly, neither will the rest of you.

Sleep quality & CIRCADIAN RHYTHM

Plant-derived spermidine has been found to improve sleep quality and reduce age-associated sleep disruption. This is thought to be because it activates some of the clock genes associated with circadian rhythm. Have a wearable sleep-tracking device? Many of our clients see their Deep Sleep & Restfulness scores shoot up after taking Primeadine®.

Energy & vitality

In addition to triggering autophagy, plant-derived spermidine has been found to activate a cellular process known as mitophagy, which clears out the old and poorly functioning mitochondria. Because the mitochondria provide energy to your cells, when they aren't functioning well you may experience low energy as a result. Reenergize your mitochondria and experience a renewed sense of energy and stamina.

Healthy Hair, skin & nails

Plant-derived spermidine has been shown to improve hair growth by moving hair follicles from the shedding phase to the growth phase. It is in this phase is that melanogenesis (hair color pigementation) takes place. It also promotes strong, healthy nails and bright, glowing skin. Welcome to your new prime!

Memory & cognition

Clinical trials have found plant-derived spermidine to improve memory and cognition in older adults. Spermidine also supports brain health by triggering cell renewal, or autophagy. Brain fog be gone!

gut health

Gut dysbiosis is one of the root causes of aging, and spermidine may reduce this by sealing the tight junctions in the gut lining that are prone to becoming leaky. As a bonus, both Primeadine® Original and GF contain prebiotics, promoting healthy digestion.

Fasting Mimetic

Experience the benefits of fasting - especially cellular renewal (autophagy) - without the need to fast.

Give Primeadine a try with our Luxury Starter Kit

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Backed by World-Renowned Scientists & Doctors

We combine the wisdom of the ancient East with the latest breakthroughs in science. Our products are formulated with the oversight of internationally recognized longevity scientists and doctors, including Oxford University Emeritus Professor of Physiology, Denis Noble, Immunology Professor Katja Simon, Head of the UK Space Innovation Lab, Dr. Ghada Alsaleh, Renowned Longevity Doctor and Author of ‘The Kaufmann Anti-Aging Protocol’, Dr. Sandy Kaufmann, and Celebrity Anti-Aging Doctor and Psychoneuroimmunologist, Dr. Olivia Lesslar, among others.

Frequently Asked Questions

Have a question? Curious to learn more? The answers to our most commonly asked questions are below and view all FAQs here.