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It is the only supplement that makes me sleep, look and feel better. The company is first class as well. I have been a long time supporter and will never stop.

— Tim K.

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Try celeb-loved healthy aging supplement, Primeadine® GF, with 15% off!

We hope you enjoyed Dr. Tom O'Bryan's 'The Inflammation Equation'. You will have seen our Founder, autoimmune disease survivor and longevity expert, Leslie Kenny in the documentary, and in the video below, she will tell you more about her health journey as an autoimmune patient and how she went out of her way to find a gluten-free version of the vital anti-aging compound, spermidine. so everyone could experience its miraculous benefits...To thank you for watching, we're giving you 15% off your first purchase.

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What is Spermidine?

Spermidine is a powerful plant-derived molecule shown to slow aging on a cellular level. It does this by addressing the root causes of aging and activating your body's fundamental cellular recycling and "clean up" process, called autophagy.

While you naturally produce spermidine when you are young, your ability to do so declines with age, impacting your ability to trigger autophagy as a result. This increases your dietary needs for spermidine and is where food-derived, supplemental sources of spermidine, like Primeadine® GF, come in handy.

Trusted by Experts

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

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Benefits of Primeadine® GF Spermidine Supplements

Healthy Aging

Plant-derived spermidine has been shown to slow aging by targetting its root causes, known as the "Hallmarks of Aging". These include gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction. One of the most important hallmarks spermidine helps with is impaired autophagy (cellular renewal), as this effects your whole body!

Enhanced Cell renewal

Plant-derived spermidine triggers autophagy, your body's internal cellular recycling and "clean up" process that declines with age. Your cells are foundational to every part of your body; if they're not functioning and regenerating properly, neither will the rest of you.

Sleep quality & CIRCADIAN RHYTHM

Plant-derived spermidine has been found to improve sleep quality and reduce age-associated sleep and circadian rhythm disruption. Have a wearable sleep-tracking device? Many of our clients see their Deep Sleep & Restfulness scores shoot up after taking Primeadine®.

Energy & vitality

In addition to triggering autophagy (cellular renewal), plant-derived spermidine has been found to activate a cellular process known as mitophagy, which clears out the old and poorly functioning mitochondria. Because the mitochondria provide energy to your cells, when they aren't functioning well you may experience low energy as a result. Reenergize your mitochondria and experience a renewed sense of energy and stamina.

Healthy Hair, skin & nails

Plant-derived spermidine has been shown to improve hair growth by moving hair follicles from the shedding phase to the growth phase and keeping them there for longer. It is in this phase that melanogenesis (hair color pigmentation) takes place. Spermidine also promotes strong, healthy nails and bright, glowing skin. Welcome to your New Prime!

Brain health, Memory & cognition

Spermidine supports brain health by triggering cellular renewal, or autophagy. Clinical trials have found plant-derived spermidine to improve memory and cognition in older adults with subjective cognitive decline. Brain fog be gone!

gut health

Gut dysbiosis is one of the root causes of aging, and spermidine may reduce this by sealing the tight junctions in the gut lining that are prone to becoming leaky.

Fasting Mimetic

Plant-derived spermidine is a calorie restriction mimetic, providing the benefits of fasting - the main one being autophagy - without the need to fast.

What Makes Primeadine® GF Unique?

100% Plant-Derived

Unlike synthetic and synthetically-enriched spermidine, Primeadine® GF contains wholly plant-derived spermidine - the only kind to be tested for safety and efficacy in humans - at a minimum effective dose of 1mg. With Primeadine® GF, it's about quality over quantity.

Clean Ingredients

We source and manufacture Primeadine® GF in the longevity islands of Okinawa, Japan, known for its extremely long-lived population and superior food quality and safety standards. We perform rigorous 3rd party testing and ensure Primeadine® GF is completely free of hidden impurities like heavy metals, mycotoxins, pesticides, fillers and flow agents.

A Unique Formula

Primeadine® GF contains a unique blend of 3 autophagy inducers and anti-inflammatories - a special, spermidine-rich strain of chlorella, nobilietin (from "Shikuwasa" citrus lime peel), and turmeric - all sourced from the longevity islands of Okinawa, Japan.

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What's Inside Primeadine® GF?

Okinawan Chlorella

We source a special, spermidine-rich sub-strain of chlorella from the longevity islands of Okinawa, Japan, where it grows in a pristine oceanfront location under sunny Okinawan skies.

Okinawan Turmeric

The Okinawan longevity islands are a combination of ancient coral rock and volcanic rock, making its soil, and thereby its turmeric, particularly potent and nutrient-dense. While turmeric is known for being a powerful anti-inflammatory, the curcumin inside has also been found to stimulate autophagy (cell renewal).

Nobiletin (from Okinawan "Shikuwasa" Citrus Lime Peel)

The flavanoid, nobiletin, is a potent autophagy inducer found in Okinawan ("Shikuwasa") citrus lime peel. Shikuwasa is Japan's national lime and is a staple in the diets of Okinawan centenarians: they drink Shikuwasa juice, use it in marinades and to flavor noodle dishes.

Backed by World-Renowned Scientists & Doctors

We combine the wisdom of the ancient East with the latest breakthroughs in science. Our products are formulated with the oversight of internationally recognized longevity scientists and doctors, including Oxford University Emeritus Professor of Physiology, Denis Noble, Immunology Professor Katja Simon, Head of the UK Space Innovation Lab, Dr. Ghada Alsaleh, Renowned Longevity Doctor and Author of ‘The Kaufmann Anti-Aging Protocol’, Dr. Sandy Kaufmann, and Celebrity Anti-Aging Doctor and Psychoneuroimmunologist, Dr. Olivia Lesslar, among others.

About our Founder

Leslie Kenny

Oxford Healthspan was founded by Leslie Kenny, an Oxford-based, Southern Californian entrepreneur and Berkeley and Harvard Business School graduate. Her life changed dramatically when she was diagnosed with a string of autoimmune diseases - lupus, rheumatoid arthritis and hypothyroidism - in her 30s and told it could only be managed, not cured, with strong immunosuppressants. On a quest to heal herself, she trained at the Institute of Integrative Nutrition in NYC and became a health coach, as well as helping scientists at top-tier European universities find funding for their ground-breaking discoveries. On this exciting career path a little-known age-defying molecule, spermidine, was brought to her attention by a University of Oxford scientist, and the rest is history.

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Frequently Asked Questions

Have a question? Curious to learn more? The answers to our most commonly asked questions are below and view all FAQs here.