the best spermidine in the market

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Kiseki Box with 3-month supply of Primeadine Original Spermidine Powder

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

  • Primeadine® is the purest food-derived spermidine supplement on the market, with zero fillers or flow agents and rigorously tested to the highest standards.

    It also comes with two other naturally occurring polyamines important to human health, spermine and putrescine, which work together with spermidine as part of a virtuous recycling loop that enables the body to make more spermidine.

    Our formulation provides you with 1mg standardized spermidine, tested in every batch to guarantee you are getting the same amount in every capsule. 

    To prevent oxidation and the presence of potentially rancid omega 6’s, our wheat germ extract is defatted and, again, tested for purity and potency. 

    We have also added a FructoOligoSacharide (FOS), a special type of resistant starch maltodextrin, that acts as a prebiotic fiber that selectively feeds two strains of gut bacteria so that your own microbiome can produce more spermidine.

    Primeadine is both a source of supplemental spermidine, spermine and putrescine in the exact ratio found in nature, and a prebiotic to increase your body’s overall levels of spermidine, while potentiating your microbiota’s innate ability to manufacture it too.


Kiseki, a 250-year old miracle

For thousands of years, the Japanese have revered the Sakura, or cherry tree, for its regenerative abilities, natural anti-bacterial, anti-viral properties, and profound beauty. An ideal medium in which to store anything delicate, samurai families began to use wild cherry tree bark over 250 years ago to craft artisanal tea caddies for storing tea,tobacco, and medicine. So, we thought, what better way to store the new Primeadine Original powder than your very own Sakura tea caddy? 

As precious things go, the opportunity to harvest wild cherry bark is rare. It can only be sourced once a year: The bark pulls gently away from the tree only during the rainy season at the end of summer.Only five artisan families in Japan continue to make these beautiful treasures of nature and the Tomioka family, with whom we work, never take more than 1/3 of the bark from a single tree so that it remains healthy and able to renew. They also only choose trees that are over 80 years old, because only the older trees are able to fully restore their bark. And if 80 year old trees can get better with age, so can we...

For me, it is fitting that we store something with replenishing qualities inside another example of nature's power to rejuvenate. I am happy to bring you this miracle of nature, or 'kiseki' in Japanese, as a way to sustainably store your Primeadine powders, capsules and tablets. I hope this becomes as much a daily ritual in your home as it is in mine and I wish you the powers of Kiseki.

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Lab tested
Made in the USA
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Primeadine® Benefits


Spermidine has been shown to keep hair follicles in the growth phase for longer. Typical results include improved hair growth (including eyelashes and eyebrows), stronger hair and nails and more vital, glowing skin 

Healthy aging

Spermidine improves healthspan by inhibiting 9 of the 12 hallmarks of aging, including stem cell and mitochondrial dysfunction, telomere shortening, inflammation, and gut dysbiosis. Supports memory, cognition, and heart health


Spermidine supports the regulation of your circadian rhythm, assists with deeper, sounder sleep, and can reduce age-associated sleep disruption

Cell renewal

Spermidine and its co-occurring polyamines trigger autophagy, your internal cellular "clean up" and renewal process that declines with age. Your cells are the foundation of every organ and tissue in your body; until they are functioning properly, neither is the rest of you

What is spermidine?

Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine inhibits 9 of the 12 Hallmarks of Aging