For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.
Primeadine® is the purest food-derived spermidine supplement on the market, with zero fillers or flow agents and rigorously tested to the highest standards.
It also comes with two other naturally occurring polyamines important to human health, spermine and putrescine, which work together with spermidine as part of a virtuous recycling loop that enables the body to make more spermidine.
Our formulation provides you with 1mg standardized spermidine, tested in every batch to guarantee you are getting the same amount in every capsule.
To prevent oxidation and the presence of potentially rancid omega 6’s, our wheat germ extract is defatted and, again, tested for purity and potency.
We have also added a FructoOligoSacharide (FOS), a special type of resistant starch maltodextrin, that acts as a prebiotic fiber that selectively feeds two strains of gut bacteria so that your own microbiome can produce more spermidine.
Primeadine is both a source of supplemental spermidine, spermine and putrescine in the exact ratio found in nature, and a prebiotic to increase your body’s overall levels of spermidine, while potentiating your microbiota’s innate ability to manufacture it too.
For thousands of years, the Japanese have revered the Sakura, or cherry tree, for its regenerative abilities, natural anti-bacterial, anti-viral properties, and profound beauty. An ideal medium in which to store anything delicate, samurai families began to use wild cherry tree bark over 250 years ago to craft artisanal tea caddies for storing tea,tobacco, and medicine. So, we thought, what better way to store the new Primeadine Original powder than your very own Sakura tea caddy?
As precious things go, the opportunity to harvest wild cherry bark is rare. It can only be sourced once a year: The bark pulls gently away from the tree only during the rainy season at the end of summer.Only five artisan families in Japan continue to make these beautiful treasures of nature and the Tomioka family, with whom we work, never take more than 1/3 of the bark from a single tree so that it remains healthy and able to renew. They also only choose trees that are over 80 years old, because only the older trees are able to fully restore their bark. And if 80 year old trees can get better with age, so can we...
For me, it is fitting that we store something with replenishing qualities inside another example of nature's power to rejuvenate. I am happy to bring you this miracle of nature, or 'kiseki' in Japanese, as a way to sustainably store your Primeadine powders, capsules and tablets. I hope this becomes as much a daily ritual in your home as it is in mine and I wish you the powers of Kiseki.
Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength
Supports memory, cognition and brain and cardiovascular health
Assists with deeper, sounder sleep and circadian reset
Boosts autophagy, which declines with age, and promotes cellular renewal
Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.
Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.
Epidemiological studies have correlated higher spermidine levels with longer life.
The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.
As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.
Stem cells lose their ability to divide as we age, and we are unable to replace cells that have migrated, differentiated, or died. As a result, we show outward symptoms of aging, such as gray hair.
As cells age, their mitochondria start to lose their integrity due to the build-up of oxidative stress. Compromised mitochondrial function leads to a number of adverse events, such as increased apoptosis induction, that correlate with aging.
Shortened telomeres are associated with aging cells that are senescent. As cells divide, the telomere ends of chromosomes get shorter. Eventually, telomerase gets silenced and the telomeres are too short for cells to divide.
As cells are exposed to environmental factors, they are subject to changes in their genome through epigenetic mechanisms. Such changes accumulate over time and have been correlated with the decline observed in aging cells.
As cells age, they show an increase in self-preserving signals that result in damage elsewhere. Altered extracellular communication with aging contributes to decline in tissue health.
As cells age, environmental stresses add up and mechanisms responsible for maintaining proper protein composition start to decline. Proteins lose their stability, autophagic processes start to fail, and misfolded proteins accumulate.
