Suitable for individuals with Celiac, Leaky Gut or SIBO (Small Intestinal Bowel Overgrowth)
Sourced & made in the longevity islands of Okinawa, Japan
Contains 3 cellular renewal (autophagy) activators
ISO22000 standard, the highest in food quality control
A natural source of vitamins B12, D, and K, biotin, folate, iron, calcium & lutein

Primeadine® GF Gluten-Free Spermidine Supplement - 3-Bottle Bundle / 90 Day Supply

Sale price$256.50 Regular price$270.00

"I’m getting a juicy night's sleep, (and I’m premenopausal, so that’s a huge benefit). Besides a satisfying rest, I have more supple skin and my lashes and hair are growing so beautifully"
- Melody

Primeadine® GF is a wholly plant-derived, gluten-free spermidine supplement sourced and made in the longevity islands of Okinawa, Japan, home to some of the world's longest-lived people. A unique blend of 3 autophagy inducers - Okinawan chlorella, nobiletin from "Shikuwasa" citrus lime peel, and turmeric - it provides 1.2mg of plant-derived spermidine per serving.

  • Supports sleep quality and circadian rhythm
  • Enhances hair growth
  • Supports skin and nail health
  • Promotes energy and vitality
  • Helps maintain gut health
Delivery Frequency
Flexible subscription plan Change, pause or skip your delivery
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Sale price$256.50 Regular price$270.00

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30 day returns
Rigorous 3rd party testing
Suitable for individuals with Celiac, Leaky Gut or SIBO (Small Intestinal Bowel Overgrowth)
Sourced & made in the longevity islands of Okinawa, Japan
Contains 3 cellular renewal (autophagy) activators
ISO22000 standard, the highest in food quality control
A natural source of vitamins B12, D, and K, biotin, folate, iron, calcium & lutein

Customer & Expert Reviews

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, cancer, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

What is Spermidine?

Spermidine is a polyamine, meaning it’s made up of amino acids. It has garnered lots of attention in the longevity sphere for its ability to inhibit 9 of the 12 hallmarks of aging, the paths down which you age. These include stem cell and mitochondrial dysfunction, gut dysbiosis, inflammation, and telomere shortening.

It also induces autophagy, your body’s cellular renewal and recycling process that is so vital to keeping you healthy.

While the name is unfortunate, it speaks to how essential it is to all human life; spermidine is found in abundance in sperm, breast milk, and the endosperm of seeds, such as wheat germ. Studies on plant-derived spermidine in humans have shown improved cognitive function, heart health, hair growth, and strengthened nails. Epidemiological studies have correlated it with a longer life.

Your gut biome and body tissues produce ⅔ of your body’s spermidine content; this is known as ‘endogenous production’. The final ⅓ comes ‘exogenously’, or from your diet. Endogenous production reduces with age, therefore your body requires a higher intake to age healthily and continue to promote cellular renewal and regeneration.

Read More

Primeadine® GF vs other Spermidine Supplements

What makes Primeadine® GF the best gluten-free spermidine supplement?


Primeadine® GF


Wholly plant-derived, not synthetic



Contains putrescine, a naturally-occurring precursor to spermidine and spermine



Contains 3 autophagy inducers: Okinawan chlorella, turmeric & "Shikuwasa" citrus lime peel



Sourced & made in the longevity islands of Okinawa, Japan



Endorsed by an esteemed board of longevity scientists & doctors



When can I Expect Results?

1-4 weeks

If you have a wearable sleep tracking device, look to see if there are any changes to your sleep within your first week of taking Primeadine®. If not, try taking it in the evening! After at least 2 weeks, you may notice you need to clip your nails sooner than expected. This is a sign of increased cell turnover. This cellular renewal will also be happening in your hair and skin.

4-12 weeks

Changes to your hair may be noticeable after 6-8 weeks (around the time you get your hair cut next). The human clinical trial done on food-derived spermidine found improvements to cognition within 12 weeks, and your energy levels should improve in this time period also.

12+ weeks:

We recommend taking Primeadine® continuously for at least 12 weeks to experience the full range of benefits from enhanced cellular renewal and inhibiting the aging pathways.

How to Take

Serving size

Serving size is 2 tablets per day with liquid at mealtime.

First time use

First time taking Primeadine® GF? We recommend tapering up to the full dose over 2 consecutive days. On Day 1, take 1 tablet with liquid at mealtime. On Day 2, take 2 tablets with liquid at mealtime and if well tolerated, remain at this dose.

Long term use

Going forward, we suggest taking Primeadine® with liquid at your last meal to kickstart autophagy before bed, or with liquid at breakfast to extend the benefits of your overnight fast.

Primeadine® GF Ingredients

✔️ Gluten-Free ✔️Vegan & Cruelty-Free ✔️ Made in an FDA-Registered Facility ✔️ Lab Tested

Okinawan Chlorella

For Primeadine® GF, we singled out a special sub-strain of chlorella that is uniquely rich in spermidine and putrescine (precursor to spermidine and spermine) We source it from the longevity islands of Okinawa, Japan where it grows in a pristine, isolated oceanfront location under sunny Okinawan skies using crystal-clean water taken from a pure volcanic, rock-filtered source in the mountains. Not only does this paint a lovely picture, but it also increases its nutrient content!

We then rigorously test it for heavy metals, mold, fungi, and bacteria at the Japan Food Research Lab (JFRL), a third-party independent testing lab. We also make sure the chlorella is easily absorbed by breaking the cell walls; this is known as "'broken cell wall chlorella" and is the only bioavailable form.

Okinawan Turmeric

The Okinawan longevity islands are a combination of ancient coral rock and volcanic rock, making its soil, and thereby its turmeric, particularly potent and nutrient-dense. While turmeric is known for being a powerful anti-inflammatory, the curcumin inside has also been found to stimulate autophagy (cell renewal).

Nobiletin (from Okinawan "Shikuwasa" Citrus Lime Peel)

The flavanoid, nobiletin, is a potent autophagy inducer found in Okinawan ("Shikuwasa") citrus lime peel. Shikuwasa is Japan's national lime and is a staple in the diets of Okinawan centenarians: they drink Shikuwasa juice, use it in marinades, to flavor noodle dishes, and even add it to an alcoholic beverage called awamori.


Have a question? Curious to learn more? The answers to our most commonly asked questions are below and view all FAQs here.

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