the best spermidine in the market


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Primeadine Original Premium Spermidine Supplement 6-bottle bundle

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

Introducing: Primeadine Original 6-bottle bundle! This is the best value for people who want to commit to increasing their healthspan and vitality through autophagy.

  • Primeadine® is the purest food-derived spermidine supplement on the market, with zero fillers or flow agents.

    It also comes with two other naturally occurring polyamines important to human health, spermine and putrescine, which work together with spermidine as part of a virtuous recycling loop that enables the body to make more spermidine.

    Our formulation provides you with 1mg standardised spermidine, tested in every batch to guarantee you are getting the same amount in every capsule. 

    To prevent oxidation and the presence of potentially rancid omega 6’s, our wheat germ extract is defatted and, again, tested for purity and potency. 

    We have also added a FructoOligoSacharide (FOS), a special type of resistant starch maltodextrin, that acts as a prebiotic fiber that selectively feeds two strains of gut bacteria so that your own microbiome can produce more spermidine.

    Primeadine is both a source of supplemental spermidine, spermine and putrescine in the exact ratio found in nature, and a prebiotic to increase your body’s overall levels of spermidine, while potentiating your microbiota’s innate ability to manufacture it too.


Made in FDA register facility
GMP quality
Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested
Made in the USA
logo of a plant
No talc
No shellac

Benefits of our Spermidine Supplement


Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength

Healthy aging

Supports memory, cognition and brain and cardiovascular health


Assists with deeper, sounder sleep and circadian reset


Boosts autophagy, which declines with age, and promotes cellular renewal

What is spermidine?

Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine inhibits 6 of the 9 Hallmarks of Aging 

Hallmark of Ageing