the best spermidine in the market

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Primeadine Original Spermidine Supplement 6-bottle bundle - 540 capsules / 180 day supply

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

Introducing: Primeadine Original 6-bottle bundle! This is the best value for people who want to commit to increasing their healthspan and vitality through autophagy.

  • Primeadine® is the purest food-derived spermidine supplement on the market, with zero fillers or flow agents.

    It also comes with two other naturally occurring polyamines important to human health, spermine and putrescine, which work together with spermidine as part of a virtuous recycling loop that enables the body to make more spermidine.

    Our formulation provides you with 1mg standardised spermidine, tested in every batch to guarantee you are getting the same amount in every capsule. 

    To prevent oxidation and the presence of potentially rancid omega 6’s, our wheat germ extract is defatted and, again, tested for purity and potency. 

    We have also added a FructoOligoSacharide (FOS), a special type of resistant starch maltodextrin, that acts as a prebiotic fiber that selectively feeds two strains of gut bacteria so that your own microbiome can produce more spermidine.

    Primeadine is both a source of supplemental spermidine, spermine and putrescine in the exact ratio found in nature, and a prebiotic to increase your body’s overall levels of spermidine, while potentiating your microbiota’s innate ability to manufacture it too.

    PLEASE NOTE: If you have batch number 207, the capsules will be slightly smaller than usual. Other than the size, these capsules are the exact same composition as our original capsules, containing the exact same amount of food-derived spermidine and prebiotic as the larger capsules. Due to customer feedback, we decided to test-run a smaller capsule size (using compression technology.) Unfortunately, we encountered technical problems when we began production at scale. This doesn’t affect the quality or efficacy of these new, smaller capsules, but it does mean it isn’t viable for future manufacturing runs. In the future, we will go back to the original, larger capsule sizes.


Primeadine® Spermidine Benefits


Spermidine has been shown to keep hair follicles in the growth phase for longer. Typical results include improved hair growth (including eyelashes and eyebrows), stronger hair and nails and more vital, glowing skin 

Healthy aging

Spermidine improves healthspan by inhibiting 9 of the 12 hallmarks of aging, including stem cell and mitochondrial dysfunction, telomere shortening, inflammation, and gut dysbiosis. Supports memory, cognition, and heart health


Spermidine supports the regulation of your circadian rhythm, assists with deeper, sounder sleep, and can reduce age-associated sleep disruption

Cell renewal

Spermidine and its co-occurring polyamines trigger autophagy, your internal cellular "clean up" and renewal process that declines with age. Your cells are the foundation of every organ and tissue in your body; until they are functioning properly, neither is the rest of you

What is spermidine?

Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

The effects of spermidine supplements on humans have been studied and have shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine inhibits 9 of the 12 Hallmarks of Aging


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