Shop Primeadine®
A clean, food-derived spermidine formulation that promotes cell renewal and healthy aging. Supports how you feel now and how you age over time, from energy and sleep to skin, hair, and long-term cellular health.
A whole-food spermidine supplement that activates autophagy — the body’s cell renewal process — to promote healthy aging, radiance, and overall wellbeing. Made with concentrated, defatted wheat germ extract, sourced in Japan.
A gluten-free, whole-food spermidine supplement sourced from the longevity islands of Okinawa, Japan. Activates autophagy — the body’s cell renewal process — to promote healthy aging, radiance, and overall wellbeing.
Our Founder & CEO, Leslie Kenny
Oxford Healthspan began with a personal search for answers.
After facing chronic illness and accelerated aging, Leslie Kenny turned to science, nutrition, and cellular health to rebuild her own wellbeing.
That journey became a mission. To create supplements that are grounded in research, made with integrity, and designed to support the body's ability to renew itself, not override it.
"Aging well should feel empowering. Primeadine is designed to support a new prime of life."
A compound your body already understands
What is spermidine?
Spermidine is a naturally occurring molecule found in every living cell.
We produce it when we’re younger, but levels decline with age and this impacts your ability to activate autophagy.
Replenishing it through carefully sourced, food-derived supplementation supports the body’s natural renewal processes, helping maintain function, resilience, and vitality over time.
Why Customers Choose Us
Recommended by trusted health professionals

@drolivialesslar
Medical Doctor with a Special Interest in Longevity & Complex Conditions

@theagingwellpodcast
Host, Aging Well Podcast and Prof of Exercise Science at Western Oregon University in Portland

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations

@timbiohacker
Europe's Leading Biohacker & Founder of the Health Optimisation Summit

@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”

@carolvorders
British TV personality & Biohacker

@lukestorey
Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

@magdalenas_secrets
Biohacker & Anti-Aging Entrepreneur

@hackmyage
Gerontologist, Biohacker & Sports Nutrition Coach

@nathalieniddam
Certified Holistic Health Coach & Biohacker

@silverliberation
Pro-Aging Influencer

@ollisovijarvi
Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

@emilycahillhealth
Health & Mindset Coach
Have any questions?
Our Oxford-based customer support team is available Monday to Friday.
Email support@oxfordhealthspan.com or call +1-469-465-8886.
What is spermidine?
Spermidine is a naturally occurring compound known as a polyamine, found in every living cell. It plays a role in supporting the body’s natural cellular maintenance processes, including autophagy, which helps cells renew and function optimally.
While the body can produce spermidine, levels tend to decline with age.
What are the benefits of spermidine?
Spermidine has been studied for its role in supporting cellular health and healthy aging. Research suggests it may contribute to:
- Cellular renewal processes such as autophagy
- Cognitive and cardiovascular health
- Hair, skin, and nail health
- Energy, sleep quality, and overall wellbeing
Many of these effects are linked to its role in supporting the body’s natural maintenance pathways.
Individual experiences vary, but customers often report improvements in energy, sleep, and visible signs of vitality over time.
What's the difference between food-derived and synthetic spermidine?
The key difference lies in how spermidine is delivered and how the body may utilise it.
Food-derived spermidine
Occurs naturally within a whole-food matrix alongside related compounds, including other polyamines such as spermine and putrescine. These naturally co-occurring compounds are part of the body’s polyamine system and may support how spermidine is processed and utilised.
Synthetic spermidine
Is produced in isolation and does not come with this natural matrix. Research into long-term use in humans is still limited compared to food-derived sources.
Why this matters
In whole foods, nutrients exist within a complex structure that can influence absorption and biological activity. Food-derived spermidine reflects this natural context.
What makes Primeadine® superior to other spermidine supplements?
Primeadine® is built around quality, simplicity, and scientific integrity.
- Food-derived spermidine, not synthetically enriched
- Developed alongside scientific advisors, including researchers connected to Oxford
- Third-party tested for purity and potency in both Japan and the USA
- Ingredients sourced from Japan, known for rigorous quality standards
- Free from unnecessary fillers, flow agents, and additives
- Carefully tested for contaminants such as heavy metals and pesticides
Each batch is produced to ensure consistency, purity, and quality.
What is the best spermidine dose to take?
One serving provides 1 mg of food-derived spermidine, consistent with levels used in scientific research.
Individual needs vary. If unsure, consult your healthcare provider before adjusting your intake.
How long does it take to notice results?
Primeadine® works by supporting natural cellular processes, which take time.
While activity begins at a cellular level from the outset, many customers report noticing more meaningful changes after 3 to 6 months of consistent use.
Benefits tend to build gradually with daily use.
Learn More on Our Blog

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