Primeadine® Original Spermidine Powder (3-Month Supply)
HEALTHY AGING | CELL HEALTH | RADIANCE
A whole-food spermidine powder designed to support healthy aging, cellular maintenance, and overall wellbeing. Made from concentrated, defatted wheat germ extract, sourced in Japan.
Please note, this product ships from our US warehouse so you will be charged customs. We recommend opting for Primeadine® Original capsules, which are shipped directly from within Canada.
OR subscribe & save 25% and receive every 3 months.
View our certificates of analysis here.
Learn what makes Primeadine unique here.
Description
Flexible support, designed for daily life
Primeadine® Original Powder is a premium, whole-food spermidine supplement made from concentrated, glyphosate-free wheat germ extract, sourced in Japan.
Designed for those who prefer a powder format, it integrates easily into your daily routine — from smoothies to breakfast bowls.
Each pouch provides a convenient 3-month supply.
Supporting your body’s natural processes
As part of the ageing process, cellular maintenance pathways can become less efficient.
Primeadine provides a naturally derived source of spermidine, which has been studied for its role in supporting processes such as autophagy — the body’s way of maintaining cellular health.
The goal is simple: to support the body, not override it.
How it may support you
Customers often report:
• More consistent energy
• Improved sleep quality
• Greater mental clarity
• Healthier-looking skin and hair
These are common signs of a body being supported over time.
Ingredients
Each serving provides 1mg of whole-food spermidine from concentrated, glyphosate-free wheat germ extract, sourced in Japan.
We also defat our wheat germ to remove polyunsaturated fatty acids (PUFAs), helping to maintain stability and quality. When left in, they can go rancid and wreak havoc in your cells.
Other ingredients:
• Corn-derived cluster dextrin
• Sodium citrate
Allergens:
Contains wheat (approx. 40mg gluten per serving).
Testing results:
Certificate of analysis - toxins
Certificate of analysiss - dose
Suggested use
Dosage: 2 level scoops per day (scoop included inside).
Mix into food or drink below 40°C (104°F), such as:
- Smoothies
- Yogurt
- Shakes
- Breakfast bowls
First time use: Start with 1 level scoop daily for 5 consecutive days. If well tolerated, increase to 2 scoops per day on the sixth day.
Who's it for
Designed for those who want to:
- Take a proactive approach to healthy aging
- Support energy, clarity, and overall wellbeing
- Integrate supplementation into food-based routines
- Use formulations grounded in science and quality
Important information
Contains concentrated wheat germ, so it's unsuitable for those with Celiac disease, wheat allergies, or those on Autoimmune Paleo, Carnivore, or Lectin-free diets. Consult your healthcare provider if unsure.
For a gluten-free option, try Primeadine GF.
Allergens: Wheat and gluten.
Free from
- Fillers, flow agents, and artificial additives
- Soy, lactose, or sugar
- PUFAs (polyunsaturated fatty acids)
- Heavy metals, pesticides (including glyphosate) and other contaminants
Quality & testing
• Manufactured to GMP standards
• Produced in FDA-registered facilities
• ISO-certified quality control
• Third-party tested in Japan and the USA
• Tested for heavy metals, contaminants, and microbiological safety
Natural variations in color and texture may occur due to the absence of fillers.
Testing results:
Certificate of analysis - toxins
Certificate of analysiss - dose
High quality & standards
Primeadine® undergoes rigorous third party testing, both in the Japan (which has the strictest food quality and safety standards in the world) and in the USA. Every batch of Primeadine is independently tested in Japan and the USA for heavy metals and microbiological safety.
Laboratory: Japan Food Research Laboratories (JFRL)
Laboratory report number: 26053672001-0101
Sample received: 4 June 2026
Certificate issued: 18 June 2026
Independently tested for purity: Every batch of Primeadine Original Powder is tested by Japan Food Research Laboratories, a laboratory accredited by the Japanese government, based in Shibuya-ku, Tokyo. These results come from report No. 26053672001-0101, sampled 4 June 2026 and issued 18 June 2026.
Spermidine content: 130 mg per 100g. Spermine: 35 mg per 100g. Putrescine: 21 mg per 100g.
Heavy metals: none detected.
Microbiological safety: aerobic plate count came in at not more than 300 per gram. Coliform bacteria, mold, yeast, coagulase-positive staphylococci, and salmonella all tested negative.
The raw Primeadine extract used in this product (Lot R-522) is separately certified for purity, meeting specification for polyamine content, heavy metals, and microbiological quality, with a three-year guarantee period when sealed and stored in a cool, dry, dark place.
View the Primeadine Original Powder Certificate of Analysis
Why our customers choose us
This product is rated 4.8 of 5.0 stars.
It has received 212 reviews.
Our Founder & CEO, Leslie Kenny
For Leslie Kenny, a Harvard-educated entrepreneur and Oxford-based longevity expert, Oxford Healthspan is not a commercial venture. It is a mission that began with a personal crisis and was answered by science.
Diagnosed with autoimmune conditions in her late 30s and told she could not conceive naturally, Leslie reversed her symptoms through immune modulation and lifestyle changes, and conceived naturally at age 43. That experience became the blueprint for everything Oxford Healthspan stands for: the radical belief that the body, given the right conditions, is capable of extraordinary things.
"Aging well should feel empowering. Primeadine is designed to support a new prime of life."
What is spermidine?
Spermidine is a naturally-occurring molecule found in every living cell. Your body produces it abundantly when you're younger, but levels decline with age, reducing your ability to activate autophagy, your cells' natural renewal and repair process.
Replenishing it through carefully sourced, food-derived supplementation supports the body's natural resilience and vitality over time.
This is not aging interrupted. This is aging activated.
What is autophagy?
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
Why whole-food, not synthetic?
Many spermidine supplements use a synthetic form, most often spermidine trihydrochloride, an isolated compound made in a lab. Primeadine Original is concentrated from glyphosate-free Japanese wheat germ. That means spermidine arrives the way it does in food, alongside its natural companions, the polyamines spermine and putrescine.
You may see supplements with a bigger number on the label. We'd rather be measured by what matters to us: where an ingredient grows, how it's grown, and how carefully every batch is tested.
Backed by Oxford science. Trusted by clinicians.
Our work is guided by an international network of scientific and clinical advisors, many of which are affiliated with the University of Oxford, across physiology, immunology, longevity science, and clinical nutrition.
This ensures our approach remains grounded in the latest research and scientific integrity, not hype and trends.
Prof Denis Noble (University of Oxford)
Emeritus Professor of Physiology and pioneer in systems biology.
Dr. Ghada Alsaleh (University of Oxford)
Researcher in immunology and autophagy, with a focus on aging and immune function.
Dr. Katja Simon (Max Delbrück Center, Berlin)
Leads research into autophagy in the immune system, including its role in cellular maintenance.
Dr. Olivia Lesslar
Celebrity longevity doctor specializing in complex chronic conditions and integrative approaches to health.
Dr. Sandra Kaufmann
"Best in medicine" longevity doctor and researcher with a background in cellular biology and aging.
Dr. Paul Ch'en (University of Oxford)
University of Oxford college GP and co-founder of the Oxford Longevity Project, with interests in preventative and holistic care for cancer.
Amy Lamotte
Clinical nutritionist specializing in personalised nutrition and immune health.
Recommended by trusted health professionals
@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It
@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
@drolivialesslar
Celebrity Anti-Aging Doctor & Psychoneuroimmunologist
Certified Holistic Health Coach & Biohacker
FAQs
Our Oxford-based customer support team is available Monday to Friday.
Email support@oxfordhealthspan.com or call +1-469-465-8886.
What is spermidine?
Spermidine is a naturally occurring compound known as a polyamine, found in every living cell. It plays a role in supporting the body’s natural cellular maintenance processes, including autophagy, which helps cells renew and function optimally.
While the body can produce spermidine, levels tend to decline with age.
What is autophagy?
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
What's the difference between food-derived and synthetic spermidine?
The key difference lies in how spermidine is delivered and how the body may utilise it.
Food-derived spermidine
Occurs naturally within a whole-food matrix alongside related compounds, including other polyamines such as spermine and putrescine. These naturally co-occurring compounds are part of the body’s polyamine system and may support how spermidine is processed and utilised.
Synthetic spermidine
Is produced in isolation and does not come with this natural matrix. Research into long-term use in humans is still limited compared to food-derived sources.
Why this matters
In whole foods, nutrients exist within a complex structure that can influence absorption and biological activity. Food-derived spermidine reflects this natural context.
What are the benefits of spermidine?
Spermidine has been studied for its role in supporting cellular health and healthy aging. Research suggests it may contribute to:
- Cellular renewal processes such as autophagy
- Cognitive and cardiovascular health
- Hair, skin, and nail health
- Energy, sleep quality, and overall wellbeing
Many of these effects are linked to its role in supporting the body’s natural maintenance pathways.
Individual experiences vary, but customers often report improvements in energy, sleep, and visible signs of vitality over time.
What makes Primeadine® superior to other spermidine supplements?
Primeadine® is built around quality, simplicity, and scientific integrity.
- Food-derived spermidine, not synthetically enriched
- Developed alongside scientific advisors, including researchers connected to Oxford
- Third-party tested for purity and potency in both Japan and the USA
- Ingredients sourced from Japan, known for rigorous quality standards
- Free from unnecessary fillers, flow agents, and additives
- Carefully tested for contaminants such as heavy metals and pesticides
Each batch is produced to ensure consistency, purity, and quality.
What's the best spermidine dose to take?
One serving provides 1 mg of food-derived spermidine, consistent with levels used in scientific research.
Individual needs vary. If unsure, consult your healthcare provider before adjusting your intake.
How long does it take to notice results?
Primeadine® works by supporting natural cellular processes, which take time.
While activity begins at a cellular level from the outset, many customers report noticing more meaningful changes after 3 to 6 months of consistent use.
Benefits tend to build gradually with daily use.
What's the difference between Primeadine Original and GF?
Both formulas deliver whole-food spermidine sourced in Japan. They differ in source, dose and what our community mentions most.
Primeadine Original comes from defatted Japanese wheat germ and provides 1mg of spermidine per 3-capsule serving. Customers most often mention hair, skin and nails. It contains a trace of gluten (40mg), so it isn't suitable for anyone with celiac disease or gluten intolerance.
Primeadine GF comes from Okinawan chlorella, with lime peel and turmeric, and provides 1.2mg per 4-tablet serving. It's fully gluten-free, and customers most often mention sleep. It contains iron and vitamin K2, so it isn't suitable for anyone with hemochromatosis or taking blood-thinning medication.
Take either at your first or last meal of the day. If you're unsure, choose based on dietary needs first, then the benefit that matters most to you.