Healthy aging · Cell health · Radiance
Primeadine® GF Gluten-Free Whole-Food Spermidine
A gluten-free, food-derived spermidine supplement sourced from Okinawa, Japan. Formulated to support your body’s natural cellular renewal process called autophagy, helping maintain vitality, radiance, and overall wellbeing.
Please note, this product ships from our US warehouse so you will be charged customs. We recommend opting for Primeadine® Original, which is shipped directly from within Canada.
Dual-country third party tested in Japan and the USA
View our certificates of analysis here.
Certified gluten free
View our certification here.
"I am especially pleased to have a gluten-free version to offer patients."
Description
Primeadine® GF is a gluten-free, food-derived spermidine supplement sourced from Okinawa, Japan, one of the world’s longest-living populations. It combines a unique blend of naturally occurring compounds from whole foods, including spermidine-rich, iodine-free chlorella, citrus-derived nobiletin, and turmeric.
Together, these ingredients are designed to support the body’s natural cellular renewal processes, including autophagy, which plays a role in maintaining cellular function over time.
Rather than relying on isolated compounds, Primeadine® GF delivers these nutrients in a food-based matrix your body can recognize and utilize more effectively.
Designed to support:
- Healthy aging
Supports normal cellular maintenance and overall wellbeing - Radiance
Helps maintain healthy skin, hair, and nails - Energy and clarity
Supports everyday vitality and cognitive function - Rest and balance
Supports general wellbeing, including sleep and daily rhythm
Ingredients
Primeadine® GF contains a blend of whole-food ingredients from Okinawa:
- Okinawan Chlorella (broken cell wall and iodine-free)
- Shikuwasa Citrus Lime Peel
- Turmeric
Providing naturally occurring:
- Spermidine (1.2mg)
- Lutein (2.57mg)
- Nobiletin (0.3mg)
- Vitamins and minerals including Vitamin D2, Vitamin K, Folate, Vitamin B12, Biotin, and Iron
Other ingredients: Tricalcium Phosphate.
Suggested use
Dosage:
Take 4 tablets daily with water, with your first or last meal.
Getting started:
Begin with 2 tablets on day one. If well tolerated, increase to the full serving.
Tablets may also be crushed and added to smoothies or food if preferred.
Who's it for
- Those taking a proactive approach to long-term health and vitality
- Those looking to support their body’s natural aging processes
- Those seeking a gluten-free, food-derived spermidine supplement
Important information
- If you are taking medication, including blood thinners, consult your healthcare practitioner before use
- If you have a medical condition, consult your healthcare practitioner before use
- Do not use if you are allergic to chlorella, citrus, or turmeric
- Discontinue use if any adverse reaction occurs
Free from
Primeadine® GF is free from:
- Gluten and wheat
- GMOs
- Soy, dairy, and lactose
- Added sugars and artificial additives
- Fillers and flow agents
Each batch is tested for heavy metals, pesticides, and contaminants.
Quality & testing
- Manufactured in GMP-certified facilities
- Produced to ISO22000 food safety standards
- Sourced from Okinawa, Japan
- Third-party tested in both Japan and the USA
- Tested for purity, potency, and contaminants
Primeadine GF Tablets Certification and Testing:
Laboratory: Japan Food Research Laboratories (JFRL)
Lot number: S32066
Laboratory report number: 26035436001-0101
Sample received: 12 June 2026
Certificate issued: 2 July 2026
Independently tested for purity: Every batch of Primeadine GF Tablets (Chlorella, Shikuwasa, and Turmeric) is tested by Japan Food Research Laboratories. These results come from Lot No. S32066, sampled 12 June 2026 and issued 2 July 2026 under report No. 26035436001-0101.
Spermidine content: 130 mg per 100g. Putrescine: 63 mg per 100g. Spermine was not detected.
Heavy metals: tested by Japan Food Research Laboratories. Results fall within limits for food supplements. Full results are in the certificate.
Iron: 24.0 mg per 100g. Vitamin D, Vitamin K, folic acid, pantothenic acid, biotin, and lutein were also tested.
Microbiological safety: aerobic plate count came in at not more than 300 per gram. Escherichia coli, mold, yeast, coagulase-positive staphylococci, and salmonella all tested negative.
Gluten content: tested separately by Delta Labs of South Florida using an ELISA assay, gluten came back below 20 ppm, meeting the threshold for a gluten-free claim under UK and EU food law.
Manufacturer's gluten-free statement: Primeadine GF Tablets are manufactured by Okinawa Ukondo Co., Ltd. at its facility in Ginowan-shi, Okinawa, Japan. The manufacturer has confirmed, in a signed statement dated 9 September 2026, that no gluten-containing ingredients are intentionally added, that the products are made in a gluten-free production area, and that procedures are in place to control and prevent cross-contact with gluten-containing materials. This statement is issued by the manufacturer and does not by itself constitute third-party gluten-free certification.
View the Primeadine GF Tablets Certificate of Analysis
Your Primeadine journey
Healthy aging starts from within
The most important work happens beneath the surface. Spermidine has been shown to support autophagy, cellular renewal and target the hallmarks of aging. Alongside this emerging science, Primeadine customers report improvements in energy, mental clarity, sleep, skin and hair.
- 01
Weeks 1–4
The Science of Cellular Renewal
Spermidine has been shown to stimulate autophagy, a natural process that helps cells break down and recycle damaged components. This cellular housekeeping is an essential part of maintaining healthy cell function.
- 02
Weeks 5–8
Mitochondrial Health & Energy
Autophagy helps maintain mitochondrial quality by clearing damaged cellular components. These processes are closely linked to energy metabolism. Some Primeadine customers also report improvements in energy, mental clarity, and sleep.
- 03
Weeks 9–12
Cellular Health, Skin & Hair
Cellular maintenance plays an important role in tissue health. Spermidine has been shown to inhibit the processes involved in cellular aging, while some customers report improvements in skin, hair and overall wellbeing.
- 04
Weeks 12+
The Hallmarks of Aging
Spermidine has been studied for its ability to target many of the hallmarks of aging, such as stem cell and mitochondrial dysfunction, telomere shortening, and loss of proteostasis. These interconnected processes play an important role in how our cells function as we age.
Compare
How Primeadine GF compares
| Feature | Primeadine GF | Synthetic spermidine |
|---|---|---|
| Source | Okinawan chlorella, Shikuwasa lime peel and turmeric | Spermidine trihydrochloride, made in a lab |
| Also provides | Lutein, nobiletin, vitamins and minerals | Spermidine only |
| Testing | Third-party tested in Japan and the USA | Varies by brand |
As seen in
New York Post
Tatler
Why it matters
Your cells slow their clean-up as you age
Spermidine is found in every living cell. Your body makes plenty when you're young, and levels decline with age. Less spermidine means less autophagy, the process your cells use to clear out and recycle worn-out parts.
Primeadine replenishes spermidine from food, to support your body's own renewal. It's designed for people who want to:
- Those taking a proactive approach to long-term health and vitality
- Those looking to support their body’s natural aging processes
- Those seeking a gluten-free, food-derived spermidine supplement
“Aging is not something to be feared, but embraced.”
Leslie Kenny, Founder and CEO, Oxford Healthspan
Customer stories
What customers notice
"My sleeping has certainly improved."
I have been using the gluten free spermidine for about six weeks now. Friends that have not seen me for a while say my skin is glowing and want to know what type of facial I am now having. The irony is that I have stopped having facials.
Video reviews
Hear it from them
The science
Spermidine, explained
Autophagy was shown to be a regulated process by Japanese scientist Yoshinori Ohsumi, whose work won the 2016 Nobel Prize in Physiology or Medicine.
Dive into the scienceWhat is spermidine?
A naturally occurring polyamine found in every living cell. It supports the body's natural cellular maintenance processes, including autophagy. Your body makes spermidine, but levels tend to decline with age.
What is autophagy?
From the Greek for "self-eating". Your cells identify, break down and recycle damaged components. It's one of the body's main renewal processes, and its role in healthy aging is well established.
Food-derived or synthetic: does it matter?
Food-derived spermidine comes in a whole-food matrix alongside related compounds that are part of the body's polyamine system. Synthetic spermidine is made in isolation, and research into its long-term use in humans is still limited.
What does the research suggest?
Spermidine has been studied for its role in cellular renewal, cognitive and cardiovascular health, hair, skin and nails, energy and sleep. Individual experiences vary.
Ingredients
Three whole foods from Okinawa
Primeadine® GF contains a blend of whole-food ingredients from Okinawa:
- Okinawan Chlorella (broken cell wall and iodine-free)
- Shikuwasa Citrus Lime Peel
- Turmeric
Providing naturally occurring:
- Spermidine (1.2mg)
- Lutein (2.57mg)
- Nobiletin (0.3mg)
- Vitamins and minerals including Vitamin D2, Vitamin K, Folate, Vitamin B12, Biotin, and Iron
Other ingredients: Tricalcium Phosphate.
Primeadine® GF is free from:
- Gluten and wheat
- GMOs
- Soy, dairy, and lactose
- Added sugars and artificial additives
- Fillers and flow agents
Each batch is tested for heavy metals, pesticides, and contaminants.
Why Oxford Healthspan
How we make Primeadine
Primeadine® undergoes rigorous third party testing, both in the Japan (which has the strictest food quality and safety standards in the world) and in the USA. Every batch is tested for heavy metals, mycotoxins, pesticides and herbicides.
- Manufactured in GMP-certified facilities
- Produced to ISO22000 food safety standards
- Sourced from Okinawa, Japan
- Third-party tested in both Japan and the USA
- Tested for purity, potency, and contaminants
View the Primeadine GF Tablets Certificate of Analysis
Tested in two countries
Batches are independently tested in Japan and the USA.
Sourced in Japan
Japan has some of the strictest food quality and safety standards in the world.
Food-derived
Primeadine GF delivers spermidine in a food-based matrix of chlorella, Shikuwasa lime peel and turmeric.
Linked to Nobel-winning research
We're the only non-Japanese company collaborating with Yoshinori Ohsumi and his team.
Our advisers
Guided by scientists and clinicians
Our international network of advisers spans physiology, immunology, longevity science and clinical nutrition. Many are affiliated with the University of Oxford.
Amy Lamotte
Clinical nutritionist specializing in personalised nutrition and immune health.
Prof Denis Noble
University of Oxford. Emeritus Professor of Physiology and pioneer in systems biology.
Dr Ghada Alsaleh
University of Oxford. Researcher in immunology and autophagy, focused on aging and immune function.
Dr Katja Simon
Max Delbrück Center, Berlin. Leads research into autophagy in the immune system.
Dr Paul Ch'en
University of Oxford college GP and co-founder of the Oxford Longevity Project.
Dr Sandra Kaufmann
Longevity doctor and researcher with a background in cellular biology and aging.
Your routine
Four tablets a day
Dosage:
Take 4 tablets daily with water, with your first or last meal.
Getting started:
Begin with 2 tablets on day one. If well tolerated, increase to the full serving.
Tablets may also be crushed and added to smoothies or food if preferred.
From our founder
Meet Leslie Kenny
Leslie Kenny is a Harvard-educated entrepreneur and Oxford-based longevity expert. Oxford Healthspan began with her own health crisis, and the science that answered it.
Practitioners and biohackers
Recommended by people who study aging
"The best spermidine supplement on the market."
"It's a staple in my supplement stack!"
"Primeadine is an exceptional quality spermidine that I use in many protocols."
"There is no question that spermidine is a crucial component to any longevity program."
"Primeadine by Oxford Healthspan is my go-to spermidine supplement."
Designed to support
What daily Primeadine supports
FAQ
Questions, answered
Our Oxford-based customer support team is available Monday to Friday. Email support@oxfordhealthspan.com or call +1-469-465-8886.
What is spermidine?
Spermidine is a naturally occurring compound known as a polyamine, found in every living cell. It plays a role in supporting the body’s natural cellular maintenance processes, including autophagy, which helps cells renew and function optimally.
While the body can produce spermidine, levels tend to decline with age.
What is autophagy?
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
What are the benefits of spermidine?
Spermidine has been studied for its role in supporting cellular health and healthy aging. Research suggests it may contribute to:
- Cellular renewal processes such as autophagy
- Cognitive and cardiovascular health
- Hair, skin, and nail health
- Energy, sleep quality, and overall wellbeing
Many of these effects are linked to its role in supporting the body’s natural maintenance pathways.
Individual experiences vary, but customers often report improvements in energy, sleep, and visible signs of vitality over time.
What's the difference between food-derived and synthetic spermidine?
The key difference lies in how spermidine is delivered and how the body may utilise it.
Food-derived spermidine
Occurs naturally within a whole-food matrix alongside related compounds, including other polyamines such as putrescine. These naturally co-occurring compounds are part of the body’s polyamine system and may support how spermidine is processed and utilised.
Synthetic spermidine
Is produced in isolation and does not come with this natural matrix. Research into long-term use in humans is still limited compared to food-derived sources.
Why this matters
In whole foods, nutrients exist within a complex structure that can influence absorption and biological activity. Food-derived spermidine reflects this natural context.
What makes Primeadine® superior to other spermidine supplements?
Primeadine® is built around quality, simplicity, and scientific integrity.
- Food-derived spermidine, not synthetically enriched
- Developed alongside scientific advisors, including researchers connected to Oxford
- Third-party tested for purity and potency in both Japan and the USA
- Ingredients sourced from Japan, known for rigorous quality standards
- Free from unnecessary fillers, flow agents, and additives
- Carefully tested for contaminants such as heavy metals and pesticides
Each batch is produced to ensure consistency, purity, and quality.
What is the best spermidine dose to take?
One 4-tablet serving provides 1.2 mg of food-derived spermidine, close to the 1 mg a day used in most studies.
Individual needs vary. If unsure, consult your healthcare provider before adjusting your intake.
How long does it take to notice results?
Primeadine® works by supporting natural cellular processes, which take time.
While activity begins at a cellular level from the outset, many customers report noticing more meaningful changes after 3 to 6 months of consistent use.
Benefits tend to build gradually with daily use.
What's the difference between Primeadine Original and GF?
Both formulas deliver whole-food spermidine sourced in Japan. They differ in source, dose and what our community mentions most.
Primeadine Original comes from defatted Japanese wheat germ and provides 1mg of spermidine per 3-capsule serving. Customers most often mention hair, skin and nails. It contains a trace of gluten (40mg), so it isn't suitable for anyone with celiac disease or gluten intolerance.
Primeadine GF comes from Okinawan chlorella, with lime peel and turmeric, and provides 1.2mg per 4-tablet serving. It's fully gluten-free, and customers most often mention sleep. It contains iron and vitamin K2, so it isn't suitable for anyone with hemochromatosis or taking blood-thinning medication.
Take either at your first or last meal of the day. If you're unsure, choose based on dietary needs first, then the benefit that matters most to you.
Reviews
What customers say
- Aysha M.Verified BuyerGender FemaleWellness Concern Hair loss, Skin Health, Sleep, Energy levels, Hormonal HealthThe Pros Easy to use, Clean ingredients3 months agoGender FemaleWellness Concern Hair loss, Skin Health, Sleep, Energy levels, Hormonal HealthThe Pros Easy to use, Clean ingredientsReviewingPrimeadine® GF Gluten-Free Whole-Food Spermidine Supplement - 1 Bottle / 30 Day SupplyRated 5 out of 5 starsLooking More Radiant
I have been using the gluten free spermidine for about six weeks now. My sleeping has certainly improved. Friends that have not seen me for a while say my skin is glowing and want to know what type of facial I am now having. The irony is that I have stopped having facials. I have been under a lot of stress because two members of my family have been very ill, yet my circles have certainly improved as well. This is a supplement I will certainly continue with.
- Katwil65Age Range 55 - 64Gender FemaleWellness Concern Hair loss, Skin Health, Sleep, Energy levels, CognitionThe Pros Easy to use, Clean ingredients, Speed of action, Science behind the product, Positive results3 months agoAge Range 55 - 64Gender FemaleWellness Concern Hair loss, Skin Health, Sleep, Energy levels, CognitionThe Pros Easy to use, Clean ingredients, Speed of action, Science behind the product, Positive resultsReviewingPrimeadine® GF Gluten-Free Whole-Food Spermidine Supplement - 1 Bottle / 30 Day SupplyRated 5 out of 5 starsGreat product!
I’ve been taking Primeadine for a little over a year now . I’ve noticed better sleep, less hair loss and hair growth where it had thinned out. My energy levels have also increased. Highly recommend.
- Carolyn M.Verified BuyerAge Range 45 - 54Gender FemaleWellness Concern Hair loss, Sleep, Energy levels, Cognition, Hormonal HealthThe Pros Easy to use, Positive results, Science behind the product3 months agoAge Range 45 - 54Gender FemaleWellness Concern Hair loss, Sleep, Energy levels, Cognition, Hormonal HealthThe Pros Easy to use, Positive results, Science behind the productReviewingPrimeadine® GF Gluten-Free Whole-Food Spermidine Supplement - 1 Bottle / 30 Day SupplyRated 5 out of 5 starsSleeping!
I didn't notice much the first 6wks or so, but now I'm sleeping through the night! Definitely sleeping more soundly, which is an added bonus. The jury is still out on whether my hair growth has improved, but hoping to see progress soon.
- DeborahVerified BuyerAge Range 65+Gender FemaleWellness Concern Sleep, Aging well, Cognition, Aches & Pains of Aging, Overall HealthThe Pros Clean ingredients, Science behind the product3 months agoAge Range 65+Gender FemaleWellness Concern Sleep, Aging well, Cognition, Aches & Pains of Aging, Overall HealthThe Pros Clean ingredients, Science behind the productReviewingPrimeadine® GF Gluten-Free Whole-Food Spermidine Supplement - 1 Bottle / 30 Day SupplyRated 4 out of 5 starsWorks
Sleeps like a rock.
- Susan H.Verified BuyerAge Range 65+Gender FemaleWellness Concern Skin Health, Aging well, Energy levels, Aches & Pains of Aging, Sleep3 months agoAge Range 65+Gender FemaleWellness Concern Skin Health, Aging well, Energy levels, Aches & Pains of Aging, SleepReviewingPrimeadine® GF Gluten-Free Whole-Food Spermidine Supplement - 1 Bottle / 30 Day SupplyRated 5 out of 5 starsAWSOME
Well it took more like 3 months before I really noticed any difference.
My hair is thicker, my nails are stronger, I am sleeping better, and the big one, my emotions are so much better, happier more grounded.
Thank you
My husband just started to take primeadine, he's been taking it for 2 weeks now. Can't wait to see how he does.
