Science-backed. Food-derived. Uncompromising quality.
Why Primeadine?
The Primeadine difference
Primeadine is our whole-food spermidine supplement, developed with guidance from Oxford University researchers and created with quality, purity and safety as top priority.
Primeadine Original delivers concentrated, defatted wheat germ sourced from Japan, one of the richest known food sources of spermidine.
Primeadine GF offers the same cellular nourishment in a gluten-free formula, drawing its spermidine from Okinawan chlorella and enriched with Shikuwasa citrus lime peel and turmeric.
We believe how a supplement is sourced and made matters just as much as what it contains.
Purity you can trust
Every batch of Primeadine is independently tested in Japan and the USA and verified free from heavy metals, pesticides, herbicides, and mycotoxins.
We source our raw ingredients from Japan, home to one of the strictest food and supplement regulatory environments in the world.
Our supplier holds ISO22000 certification, a food safety standard based on Codex Alimentarius Commission guidelines from the FAO and WHO, as well as GMP certification from the Japan Institute for Health Food Standards. Only around 150 companies in Japan hold this combination of certifications.
On arrival in the US, raw materials undergo further independent testing before encapsulation in vegan capsules at an FDA-registered, GMP-certified facility. Every batch is tested for purity, potency, heavy metals, mycotoxins, and pesticides before it ever reaches you.
Japan leads the world in longevity research, and it begins with the food. Japanese dietary culture has long been rich in spermidine-containing foods - natto, mushrooms, wheat germ - making it a natural choice for Primeadine.
Our ingredients are produced in FDA-registered facilities, manufactured under ISO 22000 food safety standards, and certified by the Japan Institute for Health Food Standards. Rigorous oversight, at every stage.
Primeadine is food-derived, not synthetic. In nature, spermidine never occurs in isolation. It exists alongside the companion polyamines spermine and putrescine, and these compounds work together in a recycling loop that may support the body's own spermidine production.
Synthetic spermidine lacks this synergy entirely, and has not undergone the same regulatory evaluation for human safety as food-derived spermidine.
Many supplement brands use fillers and flow agents to bulk out capsules or help raw materials move through manufacturing equipment. Primeadine is completely free from fillers, flow agents, talc, shellac, and any synthetic ingredients. This is a deliberate choice that reflects our commitment to delivering pure, clean, high-quality spermidine to you.
When Primeadine was first being developed, we were told we would need to add talc to make the raw material denser. We deliberately chose not to, given research raising questions about a potential association between certain talc exposures and health risks. As a result, Primeadine requires three capsules to reach the minimum effective dose of 1mg per day, a small trade-off for a cleaner formula.
Choosing not to use any flow agents means the yield per batch is slightly lower as a result, which we consider a reasonable price for purity.
Primeadine is designed to complement a healthy diet, not replace it. Whole foods remain the foundation of healthy aging, and our approach has always been to work with the body's natural biology rather than around it. That philosophy extends through every ingredient decision we make, from sourcing wheat germ in Japan to choosing Okinawan chlorella for our gluten-free formula.
We source our raw ingredients from Japan, home to one of the strictest food and supplement regulatory environments in the world.
Our supplier holds ISO22000 certification, a food safety standard based on Codex Alimentarius Commission guidelines from the FAO and WHO, as well as GMP certification from the Japan Institute for Health Food Standards. Only around 150 companies in Japan hold this combination of certifications.
On arrival in the US, raw materials undergo further independent testing before encapsulation in vegan capsules at an FDA-registered, GMP-certified facility. Every batch is tested for purity, potency, heavy metals, mycotoxins, and pesticides before it ever reaches you.
Japan leads the world in longevity research, and it begins with the food. Japanese dietary culture has long been rich in spermidine-containing foods - natto, mushrooms, wheat germ - making it a natural choice for Primeadine.
Our ingredients are produced in FDA-registered facilities, manufactured under ISO 22000 food safety standards, and certified by the Japan Institute for Health Food Standards. Rigorous oversight, at every stage.
Primeadine is food-derived, not synthetic. In nature, spermidine never occurs in isolation. It exists alongside the companion polyamines spermine and putrescine, and these compounds work together in a recycling loop that may support the body's own spermidine production.
Synthetic spermidine lacks this synergy entirely, and has not undergone the same regulatory evaluation for human safety as food-derived spermidine.
Many supplement brands use fillers and flow agents to bulk out capsules or help raw materials move through manufacturing equipment. Primeadine is completely free from fillers, flow agents, talc, shellac, and any synthetic ingredients. This is a deliberate choice that reflects our commitment to delivering pure, clean, high-quality spermidine to you.
When Primeadine was first being developed, we were told we would need to add talc to make the raw material denser. We deliberately chose not to, given research raising questions about a potential association between certain talc exposures and health risks. As a result, Primeadine requires three capsules to reach the minimum effective dose of 1mg per day, a small trade-off for a cleaner formula.
Choosing not to use any flow agents means the yield per batch is slightly lower as a result, which we consider a reasonable price for purity.
Primeadine is designed to complement a healthy diet, not replace it. Whole foods remain the foundation of healthy aging, and our approach has always been to work with the body's natural biology rather than around it. That philosophy extends through every ingredient decision we make, from sourcing wheat germ in Japan to choosing Okinawan chlorella for our gluten-free formula.
Backed by Oxford science
Our work is guided by an international network of scientific and clinical advisors, many affiliated with the University of Oxford, spanning physiology, immunology, longevity science, and clinical nutrition.
Their involvement ensures that everything we do remains grounded in the latest research and scientific integrity, not in hype, trends, or empty promises.
Professor Denis Noble (University of Oxford)
Emeritus Professor of Physiology and pioneer in systems biology. Co-founder of the Oxford Longevity Project.
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Dr. Ghada Alsaleh (University of Oxford)
Researcher in immunology and autophagy that leads the UK's first space innovation lab, with a focus on aging and immune function.
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Dr. Katja Simon (Max Delbrück Center, Berlin)
Leads research into autophagy in the immune system, including its role in cellular maintenance.
Read MoreDr. Sasi Senga (University of Oxford)
Neurosurgical oncologist and researcher focused on cancer biology.
Read More
Dr. Olivia Lesslar (Global)
Celebrity longevity doctor specializing in complex chronic conditions and integrative approaches to health. Featured in NYC Journal's 50 under 50.
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Dr. Paul Ch'en (University of Oxford)
University of Oxford college GP and co-founder of the Oxford Longevity Project, with interests in preventative and holistic care for cancer.
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Amy Lamotte (Hong Kong)
Clinical nutritionist specializing in personalised nutrition and immune health.
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Dr. Sandra Kaufmann (Miami)
"Best in medicine" longevity doctor and researcher with a background in cellular biology and aging.
Read MoreNot all spermidine is created equal.
The Primeadine difference
Primeadine
Other Spermidine supplements
100% natural and whole-food ingredients from Okinawa, the longevity island of Japan.
Synthetic or synthetically enriched to appear natural. Typically from China.
Third-party tested in both Japan and the USA. Certifications publicly available.
Sourcing and testing standards vary widely. Often opaque.
Formulations shaped by a scientific and clinical advisory board including researchers from the University of Oxford.
Trend driven "everything under the kitchen sink" formulations, not scientifically guided ones.
Spermidine, spermine, and putrescine - the full polyamine network as it appears in nature.
Synthetic spermidine yields spermidine alone, missing the co-occurring compounds your cells use it alongside.
Dosed to align with the levels tested for safety and efficacy in clinical research.
Synthetic spermidine often boasts high doses at low costs, while most clinical trials use the dose of 1mg.
Learn more on our blog
What Makes our Spermidine Supplement Different?
I often get questions from customers about our sourcing and manufacturing process. It is really heartening to see so many people doing their due diligence when looking for safe, high quality and ef...
The Lowdown on Supplement Fillers and Flow Agents
I’ve been taking supplements since I was diagnosed with autoimmune issues in 2004. I remember going to Vitamin Cottage, my local health food store in Boulder, Colorado, and being grateful to just f...
Why Defatting Wheat Germ is Essential for High Quality Spermidine Supplements
At Oxford Healthspan, we often talk about the purity and stability of the wheat germ extract used in Primeadine®. One of the most important steps in creating this high-quality extract is defatting,...
Food-Derived vs Synthetic Spermidine: What is the Difference?
The most critical distinction between synthetic and food-derived spermidine is their testing history. Synthetic spermidine has predominantly been studied in animal models, raising concerns about it...