the best spermidine in the market


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Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance, improve hair growth and fullness (including eyelashes) and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine is a polyamine, an organic compound consisting of two or more amino groups, which is positively charged at physiological pH. Spermidine is present in all human tissues.

There are three sources of spermidine: endogenous spermidine made from the precursor amino acid ornithine;microbial spermidine, produced from gut microbes, anddietary spermidine, naturally occurring in food.

Endogenous production of spermidine accounts for roughly 1/3 of the body’s spermidine, however the ability to produce spermidine endogenously decreases with age. While microbial and dietary intakes make up 2/3 of the body’s needs, dietary intakes vary greatly between countries, with spermidine intake being higher on the Mediterranean and Japanese diets than on the typical American or Western European diet.

With respect to food sources, spermidine is found in the greatest amounts in concentrated wheat germ and the Japanese fermented soybean dish known as natto. It is also found in the endosperm of all seeds and legumes, so important is it to the survival of the next generation of the plant. The algae chlorella also contains spermidine. 

Shiitake mushrooms, peas and long matured cheeses, including Cheddar and Parmesan, also contain spermidine, but the amounts will vary from batch to batch and will depend on growing, soil and harvesting conditions. 

Every batch of Primeadine® Original and Primeadine® GF is independently tested by the Japan Food Research Laboratory to ensure the amount of spermidine in each dose is the amount on the label, which is the minimum effective dose used in human clinical trials.

The concentrated and defatted wheat germ in Primeadine® Original has a beneficial ratio of spermidine to the other polyamines, spermine and putrescine. Together, they form a virtuous polyamine recycling loop, with putrescine a precursor polyamine needed by the body to make more spermine and spermidine should the body need it. 

Concentrated and defatted wheat germ derived spermidine is also well absorbed in the GI tract due to its high molecular mass. Defatting the wheat germ also means that the volatile, oxygen-seeking bonds in the wheat germ oil, which are a Polyunsaturated Fatty Acid (PUFA) like industrial seed oils, are not ingested and made part of your cell membranes. 

Primeadine® GF comes from a sub-strain of chlorella singled out from over 100 others because it alone contains a high level of spermidine and also contains putrescine, the precursor polyamine to both spermine and spermidine. Our chlorella is grown exposed to sunlight to increase the chlorophyll and other nutrient content, such as vitamins D and K, which together help drive calcium to the bones.

No, this is a supplement to a balanced diet. It is not in any way a replacement for a balanced diet.

Best effects are typically seen after 2 months.

In clinical studies, hair is the first place where spermidine leads to physically noticeable changes.
Individual results will vary.

We recommend that Primeadine® be taken once a day together with food. Results will vary from person to person.

We manufacture our Primeadine® spermidine in Japan in a Good Manufacturing Practices (GMP) compliant facility practicing ISO22000 food grade standards, the highest quality control for food manufacturing. The facilities are also registered and regularly inspected by the US Food and Drug Administration (FDA). Quality, purity and other assurance tests are conducted by the Japan Food Research Lab (JFRL) an independent food and compound testing laboratory. Once our product arrives in the United States, it must undergo another round of quality assurance tests to ensure there are no heavy metals, molds, yeasts, or other impurities present. It is then encapsulated and bottled in a US GMP compliant and FDA-registered and inspected manufacturing facility.

Orders are available from our website, which offers secure payment through Shopify and select wholesalers.

•Primeadine® GF does not contain any wheat, gluten or soy.

•Primeadine® Original contains wheat and gluten. The amount of gluten per serving size is <40mgs. A standard slice of American bread will have between 1,000 - 2,000mgs of gluten. Primeadine® Original contains 1/50th to 1/100th the amount of gluten in a single slice of bread.

•Primeadine® GF is suitable for celiacs as it does not contain any wheat, barley, rye or gluten.

•Primeadine® Original is not suitable for celiacs. It contains wheat and gluten. 

•Primeadine® GF does not contain any FODMAP's that might make SIBO worse. Always check with your healthcare practitioner if you are on a special diet.

•Primeadine® Original is a source of FODMAP's and may not be suitable for individuals with SIBO. 

•Primeadine® GF does not contain any FODMAP's and is appropriate for those on a low FODMAP's diet. 

•Primeadine® Original is a concentrated wheat germ supplement and, like all wheat germ, contains FODMAP's.

No. Primeadine® spermidine is a naturally occurring compound that is wholly derived from food sources. It is not classed as medical treatment.

We take great care to use the highest quality ingredients and to keep out the 'nasties' commonly used in the supplement manufacturing process in our products. We take the same approach that we do when baking a birthday cake for our children: we use the highest quality ingredients - no industrial seed oils such as wheat germ oil that oxidizes rapidly, no magnesium stearate to make the powder flow faster through automated encapsulation equipment (approximately 70% of all magnesium stearate used as 'flow agents' are hydrogenated industrial seed oils), no talc to make the powder denser to fit more compactly into fewer capsules. 

We also do not use synthetic spermidine (see next FAQ) which is very cheap and often 'cut' into products stating 'wheat germ with spermidine.'  

We choose food-derived spermidine. Yes, it is more costly, just as the best cake ingredients for your child's birthday cake would be too. It's a choice and philosophy about value for money. 

Synthetic spermidine is a 2-dimensional chemical mimic, but we should never forget that molecules are 3-dimensional. Humans have co-evolved with plants over millenia and our bodies recognize the 3-dimensional molecules made by plants. Our bodies can recognize some elements of 2-dimensional mimics, but they are akin to the mirror images of your hands when you put your palms together - 2-dimensionally identical, and yet your right hand cannot wear a left-handed glove. 

We have tested other spermidine products whose labels state they contain 'wheat germ with spermidine' and noticed that they have a small amount of wheat germ 'cut in' with high amounts of synthetic spermidine. Often, these are high dose, low cost options. 

Synthetic spermidine has not been tested for safety in humans. 

The US FDA has not ruled on a safe upper limit for food-derived spermidine, but the European Union's European Food Safety Authority has deemed 6mg of supplemental food-derived spermidine to be the safe upper limit. 

Synthetic spermidine has not been tested for safety in humans. 

Yes, all of our Primeadine® bottles are made of grade 1 Polyethylene terephthalate (PET or PETE).


These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.