Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

Supplementation with spermidine in humans has been shown to support cognition and heart health, promotes hormonal balance, improve hair growth and fullness (including eyelashes) and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine is a polyamine, an organic compound consisting of two or more amino groups, which is positively charged at physiological pH. Spermidine is present in all human tissues.

There are three sources of spermidine: endogenous spermidine made from the precursor amino acid ornithine;microbial spermidine, produced from gut microbes, anddietary spermidine, naturally occurring in food.

Endogenous production of spermidine accounts for roughly 1/3 of the body’s spermidine, however the ability to produce spermidine endogenously decreases with age. While microbial and dietary intakes make up 2/3 of the body’s needs, dietary intakes vary greatly between countries, with spermidine intake being higher on the Mediterranean and Japanese diets than on the typical American or Western European diet.

With respect to food sources, spermidine is found in the greatest amounts in wheat germ and fermented soy (e.g. natto and tempe). Wheat germ, in particular, has a very high spermidine content and the wheat germ in Primeadine® has a beneficial ratio of spermidine to the other polyamines, spermine and putrescine. Wheat germ derived spermidine is also well absorbed in the GI tract due to its high molecular mass.

No, this is a supplement to a balanced diet. It is not in any way a replacement for a balanced diet.

Best effects are typically seen after 2 months.

In clinical studies, hair is the first place where spermidine leads to physically noticeable changes.
Individual results will vary.

We recommend that Primeadine® be taken once a day together with food. Results will vary from person to person.

We manufacture our Primeadine® spermidine in Japan in a Japanese Good Manufacturing Practices compliant facility. Quality, purity and other assurance tests are conducted in Japan. Once our product arrives in the United States, it must undergo another round of quality assurance tests to ensure there are no toxins or other impurities present. It is then encapsulated and bottled in a US GMP compliant manufacturing facility.

Orders are available from our website, which offers secure payment through Shopify and select wholesalers (link to wholesalers).

Yes, it contains both.The amount of gluten per serving size is <40mgs. A standard slice of American bread will have between 1,000-2,000mgs of gluten. Primeadine® contains 1/50th to 1/100th the amount of gluten in a single slice of bread.

No, Primeadine® is not suitable for coeliacs.

Primeadine® is a source of FODMAP's and may not be suitable for individuals with SIBO. Consult your healthcare provider to see whether Primeadine® is suitable for you.

Yes, Primeadine® is a concentrated wheat germ supplement and, like all wheat germ, contains FODMAP's. Primeadine® may not be suitable for individuals on a low FODMAP diet. Consult with your healthcare provider to see whether Primeadine® is suitable for you.

No. It is a naturally occurring compound that can be derived from food sources. It is in no way classed as medical treatment.

Yes, all of our Primeadine® bottles are made of grade 1 Polyethylene terephthalate (PET or PETE).