About Oxford Healthspan
Longevity rooted in science
We bridge the gap between eastern wisdom and modern science by bringing to market high quality, effective and science-backed botanical compounds. Many come from the Japanese Imperial Palace Medical Scrolls that harness the body’s innate ability to repair, renew and promote vigorous longevity and increased healthspan.
Scientific Advisory Board
Emeritus Professor of Physiology, Oxford University (Oxford)
Professor Denis Noble is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Emeritus Professor and co-Director of Computational Physiology. He developed the first mathematical model of cardiac cells in 1960.
He was elected President of the International Union of Physiological Sciences (IUPS) at its Congress in Kyoto in 2009. He was then elected for a second term at the 2013 Congress in Birmingham, UK.
As a pioneer in the field of systems biology, he is the author of the first popular book on Systems Biology, The Music of Life. His most recent lectures concern the implications for evolutionary biology. His book, Dance to the Tune of Life. Biological Relativity, extends the systems approach to biology, including evolutionary biology.
Denis Noble has published more than 600 papers and 11 books.
Professor of Immunology, Oxford University (Oxford)
Professor Katja Simon is Professor of Immunology at the Kennedy Institute for Rheumatology at the University of Oxford where she studies cell fate in the hematopoietic system. She trained as an Immunologist under Avrion Mitchison at the DRFZ Berlin and found that TH1 cytokines are found in excess in human autoimmune diseases in her PhD.
As a postdoc at the Centre d'Immunologie Marseille Luminy, she investigated transcription factors regulating thymic cell death. During her second postdoc in Oxford she pursued her interest in cell fate, studying cell death molecules (Trail and FasL) in thymic selection, inflammation and tumor immunity.
As a principal investigator, she set up an independent line of enquiry investigating autophagy, another cellular process determining cell fate, in the hemato-immune system. Her group discovered that autophagy, the main conserved cellular bulk degradation pathway, maintains healthy red blood cells, stem cells and memory T cells and promotes differentiation while preventing aging of the hematopoietic system.
Dr. Ghada Alsaleh
Principal Investigator in Immunology and Autophagy & Leader of the UK’s Space Innovation Lab at Oxford University (Oxford)
Dr. Ghada Alsaleh moved to Oxford in 2017 to pursue her career as a scientist and to join Professor Katja Simon’s group at the Kennedy Institute of Rheumatology, as a post-doc, where she developed a growing curiosity about aging and the regulation of biological processes that are disturbed during the aging process. Recently, she showed that Autophagy is specifically reduced in older human lymphoid cells, which contributes to compromised memory T and B cell responses in the elderly. This work has uncovered novel targets and biomarkers for the development of anti-aging drugs for human T cells.
Ghada has recently been awarded funding for her proposal “Targeting autophagy for the treatment of osteoarthritis”. Osteoarthritis (OA) is the most common form of arthritis worldwide but lacks effective therapy. In this proposal, she aims to design a genetic screen using TFEB protein expression as a read-out to identify new potential targets for the treatment of Osteoarthritis and various age-related diseases.
Clinical Advisory Board
Dr. Paul Ch'en
Doctor to Keble and Sommerville Colleges, Oxford University (Oxford)
Dr. Paul Ch'en is a Practice Partner at the Observatory Medical Practice in Jericho, Oxford, where he is also the College Doctor to Keble and Somerville Colleges at the University of Oxford. He has a particular interest in the early diagnosis of cancer and is the creator of www.cansurehealit.com, a website devoted to leading a cancer-free life. He is also keenly interested in preventing the diseases of aging, cognitive behavioral therapy and acupuncture. Having had his early education in Japan, Dr Ch'en also stays abreast of the latest Japanese therapies and research to promote health, reverse disease and live a long, healthy and happy life.
Dr. Sandra Kaufmann
Author and Creator of the Kaufmann Anti-Aging Protocol (Miami)
Dr. Sandra Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree from the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. Presently, she is the Chief of Pediatric Anesthesia for the Memorial Health Care system and the Joe DiMaggio Children’s Hospital in Florida. She is also the author and creator of the Kaufmann Protocol, the culmination of years of non-clinical research leading to the first ever, scientific guide to personalized deceleration of the aging process.
Clinical Nutritionist (Hong Kong)
Amy Lamotte is the Managing Director of Vallotte Nutrigenomics Limited in Hong Kong, where she splits her time between clinical nutrition and nutrition research. Her clinical practice is focused on personalized nutrition for autoimmune and chronic inflammatory conditions. She devotes half of her time to research in order to contribute to our understanding of how nutrition is the key to creating vibrant health at any age. Her current research interests include nutrition for modulating the immune system and increasing healthspan, nutritional genomics, circadian biology, and the microbiome. She has a Master's of Science in Human Nutrition (summa cum laude) from the University of Bridgeport and a J.D. from Yale Law School.
Dr. Olivia Lesslar
Medical Doctor (Australia)
Dr Olivia Ly Lesslar is an Australian medical doctor who has an expertise in complex chronic conditions including neurodegeneration, "mystery illnesses", atopy, and cancer. Psychoneuroendoimmunology - the intersection of psychology, hormones, the nervous system, and the immune system is her particular passion, and she speaks regularly on podcasts, and at conventions and seminars. After medical residency in Australia, she worked across the USA. First with double-board certified neurologist and psychiatrist Dr Jay Lombard at the Neuroimmunology Associates of New York and currently, with Dr Chris Renna at LifeSpan Medicine, Los Angeles. Since 2020 she has spent more time in her home country of Australia, and now works with internationally renowned Professors - neurosurgeon Charlie Teo and immunologist allergist Pete Smtih at their respective clinics. In 2022, she was featured in the NYC Journal 50 under 50 as a distruptor in her industry.
Meet our founder
Is an autoimmune disease survivor and certified health coach. After meeting world-class Oxford scientists with potentially life-changing discoveries, Leslie realized the decade it often takes to get these discoveries from lab to consumer was a decade too long. That's when Primeadine®'s parent company, Oxford Healthspan, was born. She founded Oxford Healthspan to identify anti-aging compounds with strong clinical safety profiles and bring them to market as nutritional supplements. Spermidine is the first of those compounds.