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With respect to food sources, spermidine is found in the greatest amounts in wheat germ and fermented soy (e.g. natto and tempe). Wheat germ-derived, in particular, has a very high spermidine content and the wheat germ in Primeadine® has a beneficial ratio of spermidine to the other polyamines, spermine and putrescine. Wheat germ derived spermidine is also well absorbed in the GI tract due to its high molecular mass.

While we can’t speak directly about the formulation of other spermidine products, here are some of the main differentiators of Primeadine®/Oxford Healthspan.

- We source our raw materials from Japan, which is known for their Nobel prize winning research on autophagy. We felt they had the most advanced extraction process and rigorous quality control and testing to meet the standards of the Japan Health Food and Nutrition Food Association, so we selected them as our suppliers. In addition, our spermidine is encapsulated in a FDA cGMP facility in the US and undergoes purity testing there as well.

- Our capsules do not have any synthetic ingredients, whereas other supplements contain shellac, talc and glycerin. This makes their capsules not suitable for vegans.

- Our formulation contains a special type of maltodextrin (FOS) that acts as a prebiotic fiber and resistant starch that will selectively feed the fuso- and bacterioides bacteria in the gut biome, both of which produce spermidine. The idea behind it is to increase both supplemental, exogenous spermidine as well as your own body's ability to produce endogenous spermidine.

Initial effects are typically seen after 2 months, but benefits are cumulative over time with consistent use.

Primeadine® works at a cellular level, so you won't feel any "fireworks" the first time you take it. That said, some of our customers have reported deeper sleep, as measured by the ōura ring, when taken at night. See our Testimonials section for more!