The Best Out There!

This helped me grow so much hair back. I no longer have huge gaping bald spots. I recommend this to everyone I know.

— Marwa.

Renew From Within

Unlock Ageless Vitality With Primeadine® Spermidine Supplements

Harness the power of Japan's best-kept healthy aging secret with Primeadine® plant-derived spermidine - a celeb-loved, longevity molecule that has been shown to slow aging on a cellular level.

Shop Now

Renew From Within

Unlock Ageless Vitality With Primeadine® Spermidine Supplements

Harness the power of Japan's best-kept healthy aging secret with Primeadine® plant-derived spermidine - a celeb-loved, longevity molecule that has been shown to slow aging on a cellular level.

Shop Now

Read Our Reviews

Primeadine® Spermidine Benefits

Healthy Aging

Plant-derived spermidine slows aging on a cellular level by tackling the root causes of aging, including gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction. Our clients experience improved energy, a more youthful, vibrant appearance, and better gut health as a result.

Enhanced Cellular Renewal

Plant-derived spermidine triggers autophagy, your body's internal cellular "clean up" and recycling process that declines with age. Noticeable benefits of the cellular rejuvenation occurring within include faster growing hair and nails and better, deeper sleep.

Better Hair, Skin & Nails

Plant-derived spermidine has been proven to move hair follicles from the shedding phase to the growth phase. This is where melanogenesis (hair color pigmentation) takes place, and Primeadine® clients have reported enhanced hair growth (including lashes and brows), gray hair reversal, and stronger, healthier skin and nails.

Recommended By Scientists, Doctors & Experts

Dr. Sandra Kaufmann


"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. The products contain not only spermidine, but related polyamines which provide additional health benefits. I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

The Primeadine® Difference

Wholly Plant-Derived

Primeadine® contains wholly plant-derived spermidine, the only kind to be tested for safety and efficacy in humans and at the minimum effective dose of 1mg used in clinical trials. With Primeadine®, it's about quality over quantity.

Clean Ingredients from Japan

We source and manufacture Primeadine® in Japan, which is known for its superior food quality and safety standards and is home to some of the world's longest lived people. We also perform rigorous 3rd party testing to ensure purity and potency.

Supports Natural Production

Other beneficial polyamines naturally occur with plant-derived spermidine - spermine and putrescine - that recycle each other to make more spermidine. Primeadine Original reactivates your body's natural ability to produce it with an included prebiotic.

What Is Spermidine?

Spermidine is a potent, naturally-occurring molecule found to delay aging by tackling its root causes and activating your body’s vital cellular "spring cleaning" process, called autophagy.

While you naturally produce it when you are young, this declines with age and as a result, so does your ability to trigger autophagy, making you much more reliant on plant-derived sources like Primeadine®.


World-Class Science

It was at the University of Oxford that a scientist, autophagy expert and now one of our clinical advisors, Katja Simon, introduced our Founder, Leslie Kenny, to spermidine, and Oxford Healthspan was born. Meet our scientific and clinical board of advisors and learn more about the Nobel Prize-winning science behind spermidine below.

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About Our Founder

When Leslie was 37 she was diagnosed with a trio of autoimmune diseases - lupus, rheumatoid arthritis, and Hashimoto's Thyroiditis - and told she had five years to live. Now, at age 58, she is autoimmune disease-free, has no gray hairs, and is the biological age of 21! Find out more about her health journey below.

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Frequently Asked Questions

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Our customer support is available Monday-Friday, 9am-5:30pm UK time.Average answer time: 24h
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Blogs & Recipes

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RecipesSpermidine-Powered Cacao Ganache Recipe | Oxford Healthspan

Spermidine-Powered Cacao Ganache Recipe

Looking to elevate your dessert game with a healthy twist? This Avocado Chocolate Dip is about to become your new favorite indulgence.

RecipesSpermidine-Infused Avocado Caprese Salad Recipe

Spermidine-Infused Avocado Caprese Salad Recipe

Elevate your salad game with a burst of flavors and the added health benefits of Primeadine® spermidine in this delightful Caprese Salad. This vibrant dish brings together the classic elements of ...

RecipesAvocado Devilled Eggs with a Dash of Spermidine | Oxford Healthspan

Avocado Devilled Eggs with a Dash of Spermidine

Indulge in a tantalizing twist to classic deviled eggs with this irresistible Avocado Devilled Eggs recipe! Packed with wholesome ingredients like creamy avocado, zesty lime juice, and a dash of ...