
Enter Your New Prime With Primeadine® Spermidine
Primeadine® encapsulates Japan's best-kept healthy aging secret - a potent polyamine called spermidine shown to slow aging and increase healthspan on a cellular level. Redefine how you age with the cleanest, most bioavailable plant-derived spermidine supplement from Japan.
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Customer & Expert Reviews

@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It
There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

@drolivialesslar
Medical Doctor with a Special Interest in Longevity & Complex Conditions
Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

@carolvorders
British TV personality & Biohacker
I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

@lukestorey
Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert
The best spermidine supplement on the market.

@magdalenas_secrets
Biohacker & Anti-Aging Entrepreneur
I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

@hackmyage
Gerontologist, Biohacker & Sports Nutrition Coach
I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

@nathalieniddam
Certified Holistic Health Coach & Biohacker
Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

@silverliberation
Pro-Aging Influencer
One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

@ollisovijarvi
Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center
My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

@emilycahillhealth
Health & Mindset Coach
The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

@anetagrabiec_wellness
Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert
What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.
How Can Primeadine® Support You?

Healthy Aging
Plant-derived spermidine has been shown to increase longevity and healthspan by addressing the root causes of aging, known as the "Hallmarks of Aging". These include gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction. One of the most important hallmarks spermidine helps with is impaired autophagy (cellular renewal), as this effects them all!

Enhanced Cell renewal
Plant-derived spermidine triggers autophagy, your body's internal cellular recycling and "clean up" process that declines with age. Your cells are foundational to every part of your body; if they're not functioning and regenerating properly, neither will the rest of you.

Sleep quality & CIRCADIAN RHYTHM
Plant-derived spermidine has been found to improve sleep quality and reduce age-associated sleep and circadian rhythm disruption. Have a wearable sleep-tracking device? Many of our clients see their Deep Sleep & Restfulness scores shoot up after taking Primeadine®.

Energy & vitality
In addition to triggering autophagy (cellular renewal), plant-derived spermidine has been found to activate a cellular process known as mitophagy, which clears out the old and poorly functioning mitochondria. Because the mitochondria provide energy to your cells, when they aren't functioning well you may experience low energy as a result. Reenergize your mitochondria and experience a renewed sense of energy and stamina.


Healthy Hair, skin & nails
Plant-derived spermidine has been shown to improve hair growth by moving hair follicles from the shedding phase to the growth phase and keeps them there for longer. It is in this phase that melanogenesis (hair color pigmentation) takes place. Spermidine also promotes strong, healthy nails and bright, glowing skin. Welcome to your New Prime!

Brain health, memory & cognition
Spermidine supports brain health by triggering cellular renewal, or autophagy. Clinical trials have found plant-derived spermidine to improve memory and cognition in older adults with subjective cognitive decline. Brain fog be gone!

gut health
Gut dysbiosis is one of the root causes of aging, and spermidine may reduce this by sealing the tight junctions in the gut lining that are prone to becoming leaky. As a bonus, both Primeadine® Original and GF contain prebiotics, promoting healthy digestion and gut microbial balance.
Heart health
Plant-derived spermidine has been found to promote healthy cardiovascular function. One of the ways it does this is by increasing nitric oxide production (AKA blood flow!)







⭐⭐⭐⭐⭐ Rated 4.9/5 from 200+ reviews
BETTER HAIR, SKIN & NAILS, SLEEP & ENERGY
Primeadine® Original Spermidine Supplement - 1 Bottle / 30 Day Supply
“I just love knowing that those "accessory upgrades" are just surface-proof of the deeper good stuff that's happening in all my other organs and systems.”
- Melissa
Primeadine® Original is a wholly plant-derived spermidine supplement for healthy aging and activating cellular renewal, or autophagy. Each serving provides 1mg of the purest, most bioavailable spermidine from concentrated and defatted Japanese wheat germ extract.
- Supports sleep quality and circadian rhythm
- Enhances hair growth
- Supports skin and nail health
- Promotes energy and vitality
- Helps maintain gut health
OR switch to a subscription and save 24.44%.

Description
Promote healthy aging with Primeadine® Original plant-derived spermidine supplements. Each serving provides 1mg of spermidine in its purest, most bioavailable form from concentrated and defatted wheat germ extract.
The wholly food-derived spermidine in Primeadine® Original also comes with naturally co-occurring polyamines, putrescine and spermine. These additional polyamines, plus the special prebiotic fiber we add to support spermidine production in your gut biome, are part of a virtuous recycling loop that helps your body make more spermidine.
What are the benefits?
- Supports sleep quality
- Promotes hair growth
- Supports skin and nail health
- Promotes energy and vitality
- Supports memory, cognition, and brain health
- Helps maintain gut health
- Promotes hormonal balance
- Helps maintain healthy cardiovascular function
We recommend taking Primeadine® consistently for at least 12 weeks to experience the full benefits. Best results are seen with continuous use.
Ingredients
- Each serving provides 1mg of supplemental plant-derived spermidine from 900mg of concentrated, defatted Japanese wheat* germ extract. We defat our wheat germ extract to remove the omega 6 fatty acids (PUFAs). We do this as these can easily go rancid and become part of the outer cell membrane where they cause inflammation and leak cell components. Defatted wheat germ is also more easily absorbed in the GI tract due to its high molecular mass.
Other ingredients:
- A prebiotic fiber called FOS (fructooligosaccharide) from a special resistant starch, maltodextrin (beetroot).
- Hypromellose (plant cellulose capsule).
- Sodium citrate.
*Allergens: Wheat (Contains 40mg of gluten). In comparison, the average slice of bread contains 1,000-2,000mg of gluten.
How to Use
Serving size: 3 capsules per day, taken with liquid at mealtime.
For long term use:
We suggest taking Primeadine® with your last meal to kickstart autophagy before bed, or with your breakfast to extend the benefits of your overnight fast.
For first time use:
However, the first time you take it we recommend working up to the full daily dosage over 3 consecutive days.
Day 1: Take 1 capsule with liquid at mealtime.
Day 2: Take 2 capsules with liquid at mealtime.
Day 3: Take 3 capsules with liquid at mealtime and if well tolerated, continue at this dose.
Alternatives:
If you find 3 capsules too many to take at once, you can split the dose across the day, or open the pills and add the contents to food or drink (below 40 degrees celsius/104 degrees fahrenheit).
Avoid gluten? Try our gluten-free alternative, Primeadine® GF.
Contraindications
- Contains concentrated wheat* germ, therefore it is not suitable for individuals with Celiac disease or wheat allergy.
- It may not be suitable for individuals diagnosed with Small Intestinal Bowel Overgrowth (SIBO), if you don't tolerate legumes, or you are on an Autoimmune, Paleo, Carnivore, or lectin-free diet. Please consult your healthcare practitioner if you are unsure.
We offer a gluten-free, FODMAP-free, and lectin-free version so everyone can experience the benefits of Primeadine®. Try Primeadine® GF.
Free From
- Synthetics
- GMOs
- Soy
- Lactose
- PUFAs (polyunsaturated fatty acids)
- Heavy Metals
- Toxins
- Fillers
- Flow agents
- Sugar
- Gelatin







⭐⭐⭐⭐⭐ Rated 4.9/5 from 200+ reviews
BETTER HAIR, SKIN & NAILS, SLEEP & ENERGY
Primeadine® GF Gluten-Free Spermidine Supplement - 1 Bottle / 30 Day Supply
"I’m getting a juicy night's sleep, (and I’m premenopausal, so that’s a huge benefit). Besides a satisfying rest, I have more supple skin and my lashes and hair are growing so beautifully"
- Melody
Primeadine® GF is a wholly plant-derived, gluten-free spermidine supplement sourced and made in the longevity islands of Okinawa, Japan, home to some of the world's longest-lived people. A unique blend of 3 autophagy inducers - Okinawan chlorella, nobiletin from "Shikuwasa" citrus lime peel, and turmeric - it provides 1.2mg of plant-derived spermidine per serving.
- Supports sleep quality and circadian rhythm
- Enhances hair growth
- Supports skin and nail health
- Promotes energy and vitality
- Helps maintain gut health
Subscription includes
Free 1oz Beef Jerky Recipe

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Subscription includes
Free 1oz Beef Jerky Recipe

Description
Primeadine® GF is a potent blend of 3 autophagy inducers and 3 anti-inflammatories - Okinawan turmeric, chlorella, and nobiletin from Shikuwasa citrus lime peel - that provides 1.2mg of supplemental spermidine.
Primeadine® GF is our answer for those who avoid gluten but still want to experience the longevity and healthspan-promoting benefits of Japanese plant-derived spermidine!
What are the benefits?
- Supports sleep quality
- Promotes hair growth
- Supports skin and nail health
- Promotes energy and vitality
- Supports memory, cognition, and brain health
- Helps maintain gut health
- Promotes hormonal balance
- Helps maintain healthy cardiovascular function
We recommend taking Primeadine® GF consistently for at least 12 weeks to experience the full benefits. Best results are seen with continuous use.
Ingredients
Primeadine GF is a unique blend of only 3 ingredients.
Primeadine GF contains Okinawan Chlorella (Whole, Broken Cell Wall), Okinawan Shikuwasa (Citrus Depressa) Skin, Okinawan Turmeric (Curcuma Longa) (Whole). This provides:
- Spermidine - 1.2mg
- Lutein - 2.35mg
- Autophagy enhancer, nobiletin - 0.3mg
- Naturally-occurring sources of vitamins & minerals: vitamin D2 (7mcg), vitamin K (6mcg), folate (25mcg), vitamin B12 (0.09mcg), biotin (3mcg), pantothenic acid (0.04mg), and iron (0.3mg).
Please do not take it if you are allergic to citrus, turmeric, or chlorella.
How to Use
Serving size:
2 tablets per day, taken with a glass of water (8oz/250ml) to ensure you are adequately hydrated. You may also grind tablets and add to smoothies.
For long-term use:
Once you have established that you can take Primeadine GF during the day, you may experiment with taking Primeadine® GF either in the evening with a glass of water (8 oz/250ml) to kickstart the autophagy you will experience while sleeping, or first thing in the morning on an empty stomach to extend the benefits of overnight fasting.
For first-time use:
The first time you take it we recommend taking it with a glass of water at mealtime and working up to the full daily dosage over 2 consecutive days.
Day 1: Take 1 tablet with water at mealtime
Day 2: Take 2 tablets with water at mealtime and remain at this dose.
Contraindications
- Hemochromatosis: Due to the naturally occurring iron content, please discuss with your healthcare practitioner before taking if you have this condition.
- Please do not take it if you're allergic to citrus, turmeric, or chlorella. If you experience any negative effects or reactions, please discontinue use immediately.
Free From
- Gluten
- Soy
- Lactose
- Synthetics
- GMOs
- Heavy Metals
- Toxins
- Fillers
- Flow Agents
- PUFAs
Primeadine GF is made in an FDA-registered facility, in Okinawa, Japan, that does NOT handle wheat, shellfish, dairy, or nuts.

Spermidine is a potent, naturally-occurring molecule found to increase lifespan and healthspan by tackling the root causes of aging and activating your body’s cellular “clean up” process, called autophagy.
Spermidine is found in all cells, but is most abundant in sperm (hence the name!) and breast milk, speaking to how vital it is to all human life. We naturally produce it and get it from our diets. However, our ability to produce it declines with age, making us much more reliant on plant-based, supplemental sources of spermidine, like Primeadine®.
Learn MorePrimeadine® vs Other Spermidine Supplements
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Backed by Leading Longevity Experts
Our products are formulated with the oversight of internationally recognized longevity scientists and doctors, including Oxford University Emeritus Professor of Physiology, Denis Noble and Immunology Professor and Autophagy Expert, Katja Simon, "Best in Medicine" Longevity Doctor and Author of ‘The Kaufmann Anti-Aging Protocol’, Dr. Sandy Kaufmann, Celebrity Anti-Aging Doctor and Psychoneuroimmunologist, Dr. Olivia Lesslar, and Head of the UK's first-of-its-kind Space Innovation Lab and Autophagy Researcher, Dr. Ghada Alsaleh, among others.
Learn More
Oxford Healthspan was founded by Leslie Kenny, an Oxford-based, Southern Californian entrepreneur whose life changed dramatically when she was diagnosed with a string of autoimmune diseases - lupus, rheumatoid arthritis and hypothyroidism - in her 30s and told they could only be managed, not cured, with strong immunosuppressants. On a quest to heal herself, she trained as a health coach and her career took an interesting turn, seeing her help scientists at top-tier universities find funding for their ground-breaking discoveries. This is when a little-known longevity molecule, spermidine, was brought to her attention by an Oxford University scientist, and the rest is history.
Read MoreFrequently Asked Questions
What makes Primeadine® the best spermidine supplement?
While we can’t speak directly about the formulation of other spermidine products, here are some of the main differentiators of Primeadine®/Oxford Healthspan.
- We source our raw materials from Japan, which is known for its Nobel Prize winning scientific leadership on autophagy, or cell renewal. Japan has one of the most rigorous quality control and testing policies in the world, meaning our ingredients have the most advanced extraction process and meet the incredibly high standards of the Japan Health Food and Nutrition Food Association. They are tested for heavy metals, mold, fungi, and bacteria at the Japan Food Research Lab (JFRL), a third party independent testing lab.
- Every single batch is tested for its amount of food-derived spermidine so we ensure it contains the minimum effective dose of 1mg stated on our labels.
- Primeadine® is manufactured in Japan in an FDA-registered and -inspected facility with ISO22000 standards, the highest in food quality control. It is then encapsulated in an FDA cGMP facility in the USA and undergoes purity testing there as well at Eurofins or Delta.
- Our capsules and tablets do not contain any synthetic ingredients, whereas other supplements typically contain magnesium stearate (of which circa 80% has hydrogenated fats in it; the supplement industry is not legally required to get rid of hydrogenated oils the way the processed food industry has been mandated by law to), shellac, talc and glycerin. Our products are all suitable for vegans. Learn more about our sourcing, quality, and testing standards.
- The Primeadine® Original formulation includes a special type of prebiotic fiber, called FOS (fructooligosaccharide), that selectively feeds the friendly, spermidine-producing bacteria in the gut biome. The idea is to increase both supplemental, or 'exogenous' spermidine, as well as encourage your own body's natural ability to produce 'endogenous' spermidine in your gut biome.
- Primeadine® GF comes from a sub-strain of chlorella singled out from over 100 others because it alone contains a high level of spermidine and also contains putrescine, the precursor polyamine to both spermine and spermidine. Our chlorella is grown in the nutrient-abundant longevity islands of Okinawa, Japan, and exposed to sunlight to increase the chlorophyll and other nutrient content, such as vitamins D and K, which together help drive calcium to the bones. We combine the chlorella with two other anti-inflammatories and autophagy inducers, Okinawan turmeric and nobiletin (from Okinawan "Shikuwasa" citrus lime peel). Find out more about our ingredients.
- We do not use liposomes in Primeadine® because this is unnecessary for absorption and would prevent the benefits that happen when spermidine is exposed directly to the gut lining. There is no evidence that spermidine cannot be taken up by the cells on its own. Similar to amino acids, polyamines do not need a liposome to cross into the cell or to be taken up with epithelial cells. The process of creating a liposomal version also creates unnecessary expense.
- We do not synthetically enrich our product with synthetic spermidine. Be wary of labels that say "wheat germ with spermidine" as this indicates that the wheat germ has been soaked in synthetic spermidine, thereby increasing the overall amount of spermidine but meaning it is no longer a natural source.
- We do not use doses beyond what the European Food Safety Authority (EFSA) has mandated as safe for human consumption, which is 6mg daily. Please note that this is related to food-derived spermidine. Synthetic spermidine and synthetically enriched spermidine have never been tested in humans for safety or efficacy and are being sold without regulatory oversight.
- We work closely with our scientific and clinical advisers at the University of Oxford and abroad, all of whom take our product and share it with their loved ones. Learn more about our scientific advisory board here.
- We are also the only non-Japanese member of the Japan Autophagy Consortium, whose Senior Adviser is the 2016 Nobel Prize Winner in Medicine or Physiology, Prof Yoshimori Ohsumi, and whose Director is Prof Tamotsu Yoshimori, Osaka University. Prof Yoshimori conducted all of the mammalian research in autophagy that helped underpin Prof Ohsumi's work in yeast cells. Find out more about our story here.
Why does it matter if spermidine is synthetic or not?
Synthetic spermidine is a 2-dimensional chemical mimic, but we should never forget that molecules are 3-dimensional. Humans have co-evolved with plants over millenia and our bodies recognize the 3-dimensional molecules made by plants. Our bodies can recognize some elements of 2-dimensional mimics, but they are akin to the mirror images of your hands when you put your palms together - 2-dimensionally identical, and yet your right hand cannot wear a left-handed glove.
We have tested other spermidine products whose labels state they contain 'wheat germ with spermidine' and noticed that they have a small amount of wheat germ 'cut in' with high amounts of synthetic spermidine. Often, these are high dose, low cost options with no guarantee that they will work, or that they are safe. Synthetic spermidine has not been tested for safety or efficacy in humans, only food-derived spermidine has.
Synthetic spermidine does not contain the naturally co-occurring and beneficial polyamines, spermine and putrescine, which are present in food-derived spermidine and contribute to the good results found in studies. There is no evidence that synthetic spermidine alone would have the same benefits.
The presence of these extra polyamines make food-derived spermidine highly bioavailable as putrescine is the precursor to spermidine and spermine, creating a virtuous recycling loop that improves your body's natural spermidine production. For this reason, there is no need for the high doses featured in synthetic spermidine since wholly plant-derived products, like Primeadine®, help your body make more on its own.
Why is Primeadine® more expensive compared to other spermidine supplements?
- We take great care to use the highest quality ingredients available and to keep out the 'nasties' commonly found in the supplement manufacturing process. We take the same approach that we do when baking a birthday cake for our children: we use the highest quality ingredients - no industrial seed oils such as wheat germ oil that oxidizes rapidly and wreaks havoc in our cells, no magnesium stearate to make the powder flow faster through automated encapsulation equipment (approximately 80% of all magnesium stearate used as 'flow agents' contain hydrogenated industrial seed oils), and no talc to make the powder denser and fit more compactly into fewer capsules.
- We also do not use synthetic spermidine, which is very cheap and often 'cut' into products stating they contain 'wheat germ with spermidine.'
- We choose food-derived spermidine, sourced and manufactured in Japan, which has one of the strictest food and supplement regulatory regimens in the world. Our products undergo rigorous third party lab testing to ensure they are of the purest and most effective quality. Yes, it is more costly, just as the best cake ingredients for your child's birthday cake would be too. It's a choice and philosophy we wholeheartedly believe in and follow every step of the way.
What is the best spermidine dose to take?
The US FDA has not ruled on a safe upper limit for food-derived spermidine, but the European Union's European Food Safety Authority has deemed 6mg of supplemental food-derived spermidine to be the safe upper limit.
To date, most studies have been conducted using a daily dose of 1mg of food-derived spermidine, together with spermine and putrescine.
Synthetic spermidine has not been tested for safety in humans.
What are the benefits of plant-derived spermidine supplements?
Epidemiological studies have correlated higher plant-derived spermidine levels with a longer life.
Supplementation with food-derived spermidine in humans has been shown to support cognition and heart health, promote hormonal balance, improve hair growth and fullness (including eyelashes and brows), and strengthen nails.
This is thought to be because spermidine induces autophagy, the body’s cellular renewal and "clean up" process. It also inhibits 9 of the 12 aging pathways, known as the "Hallmarks of Aging". Some of the hallmarks spermidine acts upon include inflammation, stem cell and mitochondrial dysfunction, and gut dysbiosis.
Inhibiting the aging pathways and inducing autophagy have a whole-body effect and are responsible for the many benefits experienced when consuming plant-derived spermidine.
Other benefits noticed by our clients include deeper, sounder sleep, hair color repigmentation, enhanced energy levels, brighter, more supple skin, and improved gut health.
What is spermidine?
Spermidine is a naturally-occurring and potent polyamine (a kind of protein) known for inducing autophagy, the body's cellular renewal and recycling process. It also inhibits 9 of the 12 aging pathways, which are known as the "Hallmarks of Aging".
2/3 of the spermidine found in the human body is produced endogenously, or in the body, by the gut microbiota and various tissues. The final 1/3 is found exogenously, or externally, in the food that we eat.
As we age, our body's ability to produce it declines. To restore youthful levels of spermidine, we have to look externally. Otherwise, our cells' ability to trigger autophagy will continue to decline and the aging pathways will progress.
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