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Spermidine Benefits

Our Promise to you

We bridge the gap between eastern wisdom and modern science by bringing to market high quality, effective and science-backed botanical compounds, many from the Japanese Imperial Palace Medical Scrolls that harness the body’s innate ability to repair, renew and promote vigorous longevity and increased healthspan.

  • 2 min read
Short answer: no. Longer answer: a lot goes on from farm to capsule to make sure that Primeadine® is a safe and effective source of spermidine with multiple benefits.
  • 1 min read
Spermidine is made from SAM-e (S-adenosyl-L-methionine) and the amino acid, l-arginine. Both play an important role in how we feel, move and perform. 
  • 2 min read

High Standards For Optimal Results

GMP quality
Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested

Meet our Founder

Leslie Kenny is an autoimmune disease survivor and certified health coach. After meeting world-class Oxford scientists with potentially life-changing discoveries, Leslie realised she was in a unique position to bring these discoveries to the consumer and share ancient wisdom, now backed by science, with the world. The question she is aiming to answer: if I was able to reverse my autoimmune diseases, can I reverse aging?

In response, Oxford Healthspan, maker of Primeadine®, was born. She founded Oxford Healthspan to identify healthy aging compounds with strong clinical safety profiles and bring them to market as nutritional supplements. Primeadine®  is the first product, a food-based, spermidine-rich supplement.

Getting started with Primeadine®

We answer your most common questions so that you can maximize the benefits from taking Primeadine® from Day 1.

Why Spermidine?

Read about the myriad benefits of this potent polyamine, known for inducing autophagy, the body's cellular renewal and recycling process that slows as we age.

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Frequently Asked Questions

With respect to food sources, spermidine is found in the greatest amounts in wheat germ and fermented soy (e.g. natto and tempe). Wheat germ-derived, in particular, has a very high spermidine content and the wheat germ in Primeadine® has a beneficial ratio of spermidine to the other polyamines, spermine and putrescine. Wheat germ derived spermidine is also well absorbed in the GI tract due to its high molecular mass.

While we can’t speak directly about the formulation of other spermidine products, here are some of the main differentiators of Primeadine®/Oxford Healthspan.


- We source our raw materials from Japan, which is known for their Nobel prize winning research on autophagy. We felt they had the most advanced extraction process and rigorous quality control and testing to meet the standards of the Japan Health Food and Nutrition Food Association, so we selected them as our suppliers. In addition, our spermidine is encapsulated in a FDA cGMP facility in the US and undergoes purity testing there as well.


- Our capsules do not have any synthetic ingredients, whereas other supplements contain shellac, talc and glycerin. This makes their capsules not suitable for vegans.


- Our formulation contains a special type of maltodextrin (FOS) that acts as a prebiotic fiber and resistant starch that will selectively feed the fuso- and bacterioides bacteria in the gut biome, both of which produce spermidine. The idea behind it is to increase both supplemental, exogenous spermidine as well as your own body's ability to produce endogenous spermidine.

Initial effects are typically seen after 2 months, but benefits are cumulative over time with consistent use.

Primeadine® works at a cellular level, so you won't feel any "fireworks" the first time you take it. That said, some of our customers have reported deeper sleep, as measured by the ōura ring, when taken at night. See our Testimonials section for more!