Primeadine® Original Spermidine Supplement - 3-Bottle Bundle Hand held
Primeadine Original and Gluten Free with glass of water

Renew from Within with Primeadine®

Harness the power of Japan's best-kept healthy aging secret with Primeadine® plant-derived spermidine - a celeb-loved, longevity molecule that has been shown to slow aging on a cellular level.

Shop Now

Renew from Within with Primeadine®

Harness the power of Japan's best-kept healthy aging secret with Primeadine® plant-derived spermidine - a celeb-loved, longevity molecule that has been shown to slow aging on a cellular level.

Shop Now

Read Our Reviews

Welcome to Your New Prime

What are the Benefits of Primeadine®?

Healthy Aging

Tackles the root causes of aging, including gut dysbiosis, inflammation, and mitochondrial dysfunction. Typical results include improved energy, a more youthful appearance, and better gut health.

Enhanced Cellular Renewal

Triggers autophagy, your body's internal cellular "clean up" and recycling process that declines with age. Noticeable benefits include faster growing hair and nails, and brighter, clearer skin.

Better Hair, Skin & Nails

Shown to move hair follicles from the shedding phase to the growth phase (where hair color pigmentation also occurs). Clients report new hair growth, gray hair reversal, and healthier skin and nails.

Recommended by Experts

Dr. Olivia Lesslar

@drolivialesslar

Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Nadine Artemis

@nadineartemisofficial

Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Sandra Kaufmann

@kaufmannantiaging

"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. The products contain not only spermidine, but related polyamines which provide additional health benefits. I highly recommend this product line to all of my patients.

Carol Vorderman

@carolvorders

British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey

@lukestorey

Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj

@magdalenas_secrets

Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima

@dr.stephanie.estima

Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou

@hackmyage

Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam

@nathalieniddam

Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi

@ollisovijarvi

Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

The Primeadine® Difference

Wholly Plant-Derived

Plant-derived spermidine, at a dose of 1mg, is the only type and amount of spermidine to be tested for safety and effectiveness in humans.

Clean Ingredients from Japan

Japan is known for its superior food quality and safety standards, ensuring Primeadine is potent and free from impurities like heavy metals and pesticides.

Supports Natural Production

Other beneficial polyamines, spermine and putrescine, naturally occur with plant-derived spermidine and recycle eachother to make more spermidine.

Japan Wheat Oxford Healthspan

What is Spermidine?

Spermidine is a naturally-occurring molecule found to delay aging by tackling its root causes and activating cellular renewal.

While you naturally produce it when you are young, this declines with age, making you much more reliant on plant-derived sources like Primeadine®.

Discover
Oxford University Oxford Healthspan

World-Class Science

It was an University of Oxford scientist that introduced our Founder, Leslie Kenny, to spermidine, and thus, Oxford Healthspan was born. Meet our scientific and clinical board of advisors and learn more about the Nobel Prize-winning science behind spermidine below.

Learn More
Leslie Kenny Oxford Healthspan Founder

About Our Founder

When Leslie was 37 she was diagnosed with a trio of autoimmune diseases - lupus, rheumatoid arthritis, and Hashimoto's Thyroiditis - and told she had five years to live. Now, at age 58, she is autoimmune disease-free, has no gray hair, and is biologically 21.

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Frequently Asked Questions

See all FAQs or contact us!

Our customer support is available Monday-Friday, 9am-5:30pm UK time.Average answer time: 24h
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Read our Blog & Recipes

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RecipesCacao Collagen Protein Bars

Cacao Collagen Protein Bar Recipe

Indulge your taste buds with a guilt-free snack packed with skin-loving and longevity-promoting benefits.

Prebiotic fiber

The Benefits of Prebiotics for Brain Function & Longevity

As we age, the resilience of the gut microbiome diminishes, causing gut dysbiosis, and this is recognized as one of the of the root causes of aging known as the "hallmarks of aging". This makes ind...

Hallmarks Of AgingFasting, Image Shows Empty Wooden Bowl with Spoon | Oxford Healthspan

Deregulated Nutrient Sensing: Hallmark of Aging #5

There are many cues to tell us when we are hungry – it could be the growling and gurgling of the belly, feeling low energy, or even the ring of the lunch bell. On a cellular level, hunger is, in pa...