Age on your own terms with Primeadine

Whole-food spermidine supplements, sourced from Japan and guided by Oxford science. Designed to support cellular renewal and healthy aging from within.

Shop now

Why our customers choose us

High quality & standards

Primeadine® undergoes rigorous third party testing, both in Japan (which has the strictest food quality and safety standards in the world) and in the USA. Every batch of Primeadine is independently tested in Japan and the USA for heavy metals and microbiological safety.

View our Certificates of Analysis and Testing.

Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested
logo of a plant

Science-led. Whole-food. EST. OXFORD.

What makes us different?

Primeadine® is designed with one principle in mind: support the body’s natural ability to renew itself, with nothing unnecessary added.

Rooted in Oxford science

Developed with leading scientists and advisors from Oxford, grounded in cutting-edge research into spermidine and cellular aging. The only non-Japanese member of the Japan Autophagy Consortium, led by Nobel Prize-winner Yoshinori Ohsumi.

Whole-food, naturally bioavailable

Food-derived spermidine delivered within its natural polyamine matrix, at levels consistent with clinical research. Third-party tested for purity and potency.

Cell renewal, simplified

Spermidine supports autophagy, your body's built-in process for clearing out what no longer serves and making space for healthier cells.

Healthy aging, from the inside out

Not targeting a single outcome. Working at a foundational level, supporting how your body functions and renews over time.

Feel the difference

More consistent energy. Deeper sleep. Healthier hair, skin, and nails. Benefits that build gradually over three to six months.

Our Founder & CEO, Leslie Kenny

For Leslie Kenny, a Harvard-educated entrepreneur and Oxford-based longevity expert, Oxford Healthspan is not a commercial venture. It is a mission that began with a personal crisis and was answered by science.

Diagnosed with autoimmune conditions in her late 30s and told she could not conceive naturally, Leslie reversed her symptoms through immune modulation and lifestyle changes, and conceived naturally at age 43. That experience became the blueprint for everything Oxford Healthspan stands for: the radical belief that the body, given the right conditions, is capable of extraordinary things.

"Aging well should feel empowering. Primeadine is designed to support a new prime of life."

Meet our scientific & clinical advisory board

A compound your body already knows

What is spermidine?

Spermidine is a naturally-occurring molecule found in every living cell. Your body produces it abundantly when you're younger, but levels decline with age, reducing your ability to activate autophagy, your cells' natural renewal and repair process.

Replenishing it through carefully sourced, food-derived supplementation supports the body's natural resilience and vitality over time.

This is not aging interrupted. This is aging activated.

Learn more
Autophagy Oxford Healthspan

What is autophagy?

Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.

The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.

Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.

Dive into the science

Backed by Oxford science. Trusted by clinicians.

Our work is guided by an international network of scientific and clinical advisors, many of which are affiliated with the University of Oxford, across physiology, immunology, longevity science, and clinical nutrition.

This ensures our approach remains grounded in the latest research and scientific integrity, not hype and trends.

Prof Denis Noble (University of Oxford)

Emeritus Professor of Physiology and pioneer in systems biology.

Dr. Ghada Alsaleh (University of Oxford)

Researcher in immunology and autophagy, with a focus on aging and immune function.

Dr. Katja Simon (Max Delbrück Center, Berlin)

Leads research into autophagy in the immune system, including its role in cellular maintenance.

Dr Olivia Lesslar | Oxford Healthspan

Dr. Olivia Lesslar

Celebrity longevity doctor specializing in complex chronic conditions and integrative approaches to health.

Dr Sandra Kaufmann | Oxford Healthspan

Dr. Sandra Kaufmann

"Best in medicine" longevity doctor and researcher with a background in cellular biology and aging.

Dr. Paul Ch'en (University of Oxford)

University of Oxford college GP and co-founder of the Oxford Longevity Project, with interests in preventative and holistic care for cancer.

Amy Lamotte | Oxford Healthspan

Amy Lamotte

Clinical nutritionist specializing in personalised nutrition and immune health.

Recommended by trusted health professionals

Dr. Olivia Lesslar

@drolivialesslar

Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Dr. Jeff Armstrong

@theagingwellpodcast

Host, Aging Well Podcast and Prof of Exercise Science at Western Oregon University in Portland

I started Primeadine last night. Impatient as I am, I started at 3 capsules. Despite disrupted sleep, I had my best recorded REM sleep (1:35, 24%) and good restorative sleep. I am impressed! My “Biocharge” on my Helio Strap has been low. I was still “low” but significantly improved considering I went to bed at a 5 (drained)… [it] is the highest I have been in a while.

Nadine Artemis

@nadineartemisofficial

Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Tim Gray

@timbiohacker

Europe's Leading Biohacker & Founder of the Health Optimisation Summit

Primeadine by Oxford Healthspan is my go-to spermidine supplement. Made with rigorously tested Japan-sourced ingredients and a unique prebiotic to boost gut production, it’s unmatched in quality and effectiveness and doesn't have the nasty additional bulking agents like other brands.

Dr. Sandra Kaufmann

@kaufmannantiaging

"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. The products contain not only spermidine, but related polyamines which provide additional health benefits. I highly recommend this product line to all of my patients.

Dr. Stephanie Estima

@dr.stephanie.estima

Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Carol Vorderman

@carolvorders

British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey

@lukestorey

Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj

@magdalenas_secrets

Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Zora Benhamou

@hackmyage

Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam

@nathalieniddam

Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi

@ollisovijarvi

Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

Have any questions?

Our Oxford-based customer support team is available Monday to Friday.

Email support@oxfordhealthspan.com or call +1-469-465-8886.

Dive deeper on our blog

Visit blog
NewsWhat Two New Studies Reveal About Dietary Spermidine

What Two New Studies Reveal About Dietary Spermidine

Two new 2026 studies from the Danish POLYCAD cohort found that higher dietary spermidine intake was associated with better cardiorespiratory fitness, leaner body composition, and greater mitochondr...

Longevity LifestyleOctober's Harvest: Seasonal Foods for Longevity

October's Harvest: Seasonal Foods for Longevity

There is a particular kind of wisdom in October. The light turns golden, the air sharpens, and nature does something quietly remarkable: it lets go of what it no longer needs so it can renew. Trees...

SpermidineWhat Is the Best Spermidine Supplement? A 2026 Comparison Guide

What Is the Best Spermidine Supplement? A 2026 Comparison Guide

The best spermidine supplement is one that pairs a clean, whole-food source with transparent testing and a formulation your body recognizes. On those measures, Primeadine by Oxford Healthspan ranks...

Follow us at @oxfordhealthspan

Join us on social media to learn more