Spermidine Molecule Oxford Healthspan

What is Spermidine?

Spermidine is a naturally-occurring polyamine that induces autophagy, your body's cellular "clean up" and recycling process. It also targets 9 of the 12 root causes of aging, known as the "Hallmarks of Aging".

When you are young, you produce 2/3 of your spermidine content needs in your gut biome and body tissues. The final 1/3 comes from your diet. 

As you age, your body's ability to produce it declines and you become much more reliant on food-derived, supplemental sources.

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Are There Any Studies On Spermidine?

Spermidine supplementation in humans has been shown to have several positive effects including protecting brain and heart health, improving hair growth and fullness, and strengthening nails.

Epidemiological studies associate spermidine intake with a longer life.

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Spermidine & The "Hallmarks Of Aging"

According to a landmark paper by Lopez-Otin et al, aging is driven by 12 “hallmarks”. Among them are impaired autophagy, stem cell and mitochondrial dysfunction, inflammation, and gut dysbiosis, which all are known to be reduced by spermidine supplementation.

Spermidine is one of few known compounds thought to reduce or reverse the effects of multiple hallmarks; through its induction of autophagy, in particular, it is thought to impact 9 of the 12 hallmarks. 

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Autophagy Oxford Healthspan

Autophagy: Nobel Prize Winning Science

Autophagy is a Greek word that translates to mean "self eating". It refers to a vital cellular "clean up" and recycling process that clears out old cellular debris to make way for new, healthy ones.

It is so ground-breaking that the Japanese scientist, Yoshinori Ohsumi, who discovered its mechanism of action won the Nobel Prize (and we are the only non-Japanese company to work with him and his team!)

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Scientific Advisory Board

Professor Denis Noble

Dr. Ghada Alsaleh

Dr. Katja Simon

Dr. Sasi Senga

Clinical Advisory Board

Dr. Olivia Lesslar

Dr. Sandra Kaufmann

Dr. Paul Ch'en

Amy Lamotte

Longevity Research

Oxford Healthspan is the only non-Japanese member of the Japan Autophagy Consortium, an organization dedicated to educating the public on autophagy. Learn more here.

Our Founder Leslie started a non-profit organization, Oxford Longevity Project, with University of Oxford scientists and doctors to equip the public with the tools to age healthily. We are sponsoring their upcoming event, the Smart Ageing Summit 2024. Find out more here.


1. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The Hallmarks of Aging. Cell153(6), 1194.

2. Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022). Mechanisms of spermidine-induced autophagy and geroprotection. Nature Aging2(12), 1112-1129.

3. Madeo, F., Bauer, M. A., Carmona-Gutierrez, D., & Kroemer, G. (2019). Spermidine: A physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy15(1), 165-168.