Made from concentrated & defatted Japanese wheat germ extract
Each serving contains 1mg of supplemental spermidine
Supports natural spermidine production with added prebiotic
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Vegan & cruelty free

Primeadine® Original Spermidine Supplement

Sale price$90.00
Sale price Regular price$90.00

Primeadine® Original is a food-derived spermidine supplement from Japan for healthy aging and enhanced cell renewal.

  • Mimics the benefits of fasting
  • Supports sleep quality and circadian rhythm
  • Enhances hair growth
  • Increases energy levels and vitality

Please note, this supplement contains gluten.

Delivery Frequency
Flexible subscription plan Change, pause or skip your delivery
Easy cancellations You can manage or cancel your subscription online
Sale price$90.00
Sale price Regular price$90.00
Sale price Regular price$90.00

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Made from concentrated & defatted Japanese wheat germ extract
Each serving contains 1mg of supplemental spermidine
Supports natural spermidine production with added prebiotic
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Vegan & cruelty free

Read Our Reviews

Welcome to Your New Prime

What are the Benefits of Primeadine®?

Healthy Aging

Tackles the root causes of aging, including gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction. Typical results include improved energy, a more youthful appearance, and better gut health.

Enhanced Cell Renewal

Triggers autophagy, your body's internal cellular "clean up" and recycling process that declines with age. Noticeable benefits of the deeper cellular renewal occurring within include faster growing hair and nails, and brighter, clearer skin.

Better Hair, Skin & Nails

Shown to move hair follicles from the shedding phase to the growth phase, which is also where hair color pigmentation occurs. Our clients report enhanced hair growth (including lashes & brows), gray hair reversal, and healthier skin and nails.

Sounder Sleep

Proven to regulate 2 of the 8 clock genes associated with circadian rhythm and reduce age-associated sleep disruption, it promotes better, deeper sleep (as seen by our clients' sleep tracker scores!)

Improved Memory & Cognition

Supports brain health by triggering autophagy. Clinical trials have found plant-derived spermidine to improve memory and cognition in older adults with subjective cognitive decline. Brain fog be gone!

Japan Wheat Oxford Healthspan

What Is Spermidine?

Spermidine is a potent plant-derived compound found to increase longevity and healthspan. It does this by addressing the root causes of aging and activating your body's cellular renewal process, called autophagy, which declines with age.

We naturally produce spermidine, but our ability to do so declines with age, increasing our dietary needs.

Learn More

Recommended by Scientists, Doctors & Experts

Dr. Olivia Lesslar


Celebrity Anti-Aging Doctor & Psychoneuroimmunologist

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Dr Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Primeadine® vs other Spermidine Supplements

What makes Primeadine® the best spermidine supplement out there?




100% plant-derived, not synthetic



Contains other beneficial, naturally-co-occurring polyamines, spermine & putrescine



Endorsed by Oxford University scientists & doctors



Improves natural spermidine production



Sourced & made in Japan



When Can I Expect Results?

1-4 weeks

If you have a wearable sleep tracking device, look to see if there are any changes to your sleep scores within your first week of taking Primeadine. If not, try taking it right before bed! After at least 2 weeks, you may notice you need to clip your nails sooner than expected. This is a sign of increased cell turnover. This cellular renewal will also be happening in your hair and skin.

4-12 weeks

Changes to your hair may be noticeable after 6-8 weeks (around the time you get your hair cut next). The human clinical trial done on food-derived spermidine found improvements to cognition within 12 weeks.

12+ weeks

We recommend taking Primeadine continuously to experience the full range of benefits from enhanced cellular renewal and addressing the root causes of aging.

How To Take

Serving size

Serving size is 3 capsules per day with liquid at mealtime.

First time use

We recommend tapering up to the full dose over 3 consecutive days. On Day 1, take 1 capsule, on Day 2, take 2 capsules, on Day 3, take 3 capsules.

Long term use

Going forward, we suggest taking Primeadine® with liquid at your last meal to kickstart autophagy before bed, or with liquid at breakfast to extend the benefits of your overnight fast.


Have a question? Curious to learn more? The answers to our most commonly asked questions are below.

Our customer support team is available Monday to Friday, 9am to 5:30pm UK time.Average answer time: 24h
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