In a landmark paper published in Cell (that’s a really good one) in 2013, Lopez-Otin et al set forth nine hallmarks of aging. And, the paper has been cited thousands of times without real refutation. To be named a hallmark, it fulfills (to varying the degrees) the following three criteria:

• It should manifest or happen during normal aging.
• Experimental acceleration or increase of the hallmark accelerates normal aging
• Experimental reduction of the hallmark slows normal aging

Sadly, there’s no quick fix for the effects of aging or the extra pounds that sometimes (and so easily) sneak onto our waistlines. But, there is a simple behavior that can combat time (yes, really) and the effects of eating a little too much or exercising not quite enough.

Coffee taken in a fasted state continues the work of autophagy and you can have it any time of day with some Primeadine Original spermidine powder and still get the benefits of autophagy.