



Primeadine® Original Powder (3-Month Supply)
Primeadine® Original Powder is a plant-derived spermidine supplement from concentrated Japanese wheat germ, designed for easy mixing into smoothies or shakes. It activates cell renewal (autophagy) and addresses aging's root causes like inflammation, telomere shortening, and stem cell and mitochondrial dysfunction.
Please note, this supplement contains wheat and gluten. Gluten-free alternative here.
This product is eligible for FREE shipping.
This product is eligible for free shipping.
Description
Primeadine® Original Powder is a premium, plant-based spermidine supplement sourced from Japanese wheat germ extract in an easy-to-use, powdered format. Each dose delivers 1mg of bioavailable spermidine, plus FOS prebiotic fiber to boost natural spermidine production.
Each pouch offers a 3-month supply, is re-sealable for freshness, and easily mixes with smoothies, shakes, yogurt, and more.
Food-derived spermidine promotes a vital cellular "clean-up" and recycling system, called autophagy. Mimicking the longevity benefits of fasting and targeting key aging pathways, it:
- Reduces inflammation, rejuvenates stem cells and mitochondria, and improves telomere length
- Increases keratin production for enhanced hair growth
- Promotes collagen synthesis and wound healing for better skin and nails
- Boosts energy, memory and cognition
- Supports sleep quality, regulates the circadian rhythm, and balances hormonal and gut health
Since our natural ability to produce spermidine declines with age, we recommend taking Primeadine® on a consistent, long-term basis.
Ingredients
Each serving provides 1mg of plant-derived spermidine from concentrated, defatted Japanese wheat* germ extract. Defatting removes omega-6 fatty acids, reducing the risk of rancidity and inflammation.
Other ingredients:
- Prebiotic Fiber (FOS) from Resistant Dextrin (Beetroot).
- Sodium Citrate.
*Allergens: Wheat (Contains 40mg of gluten). In comparison, the average slice of bread contains 1,000-2,000mg of gluten.
How to Use
Dosage: 1g (approx. 1/2 a level teaspoon) added to any food or drink below 104F (40C), such as smoothies, shakes, and yogurt.
Contraindications
Contains concentrated wheat germ, so it's unsuitable for those with Celiac disease, wheat allergies, or those on Autoimmune Paleo, Carnivore, or Lectin-free diets. Consult your healthcare provider if unsure.
It also contains a prebiotic fiber, which may not be well-tolerated by those with SIBO (small intestinal bacterial overgrowth) or that find it difficult to digest legumes.
For a gluten-free option without added prebiotic fiber, try Primeadine GF.
Allergens: Wheat and gluten.
Quality & Testing
- Good Manufacturing Practices (GMPs)
- ISO2200 standard, the highest in food quality control
- Sourced in Japan and Made in the USA in FDA-certified facilities
- Rigorous third party testing in Japan and the USA
- Thoroughly tested for heavy metal, contaminant, and microbiological analysis by third party, FDA-registered, ISO-certified laboratories
- Wheat germ is defatted to remove potentially rancid PUFAs (polyunsaturated fatty acids) which, if left in, can cause inflammation in the cells

What are the Benefits?
As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.



Targets the root causes of aging, reducing inflammation, regenerating stem cells and mitochondria, protecting telomeres, and strengthening the gut lining.
Supports keratin and collagen production, improves wound healing, and harmonizes hormonal and gut health. Reflects in a radiant glow and healthier hair and nails.
Brings your circadian rhythm, gut health, and hormones into equilibrium for improved sleep quality, elevated energy levels, and increased focus and cognition.

What is Spermidine?
Spermidine is a naturally occurring polyamine that activates autophagy, the body's process of clearing out and renewing cells, and targets the root causes of aging.
In youth, about two-thirds of spermidine is produced internally, with the rest from food. As production declines with age, dietary and supplemental sources become crucial for maintaining optimal levels.
Learn more


We opt for plant-derived spermidine, the safest, most bioavailable form, and ensure our products are free from unhealthy additives like magnesium stearate. We also defat our wheat germ to remove rancid, inflammation-causing PUFAs.
Sourced in Japan, home to the world's longest-lived people and strict food standards, Primeadine meets the highest ISO2200 quality control. Rigorous third-party testing in Japan and the USA ensures purity and potency.
Food-derived spermidine is better absorbed than synthetic due to natural co-factors that enhance bioavailability, the food matrix effect, and gut bacteria interactions. We also add FOS, a prebiotic fiber, to boost natural production.
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Recommended by Experts

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It
There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

@drolivialesslar
Celebrity Anti-Aging Doctor & Psychoneuroimmunologist
Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

Certified Holistic Health Coach & Biohacker
Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!
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