the best spermidine in the market

Due to strong demand, Primeadine GF is currently sold out in the US, Canada, Hong Kong and Singapore, but you can be the first to have your order fulfilled when it is back in stock later this month by ordering now! Primeadine Original is still in stock with orders shipping immediately.

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Primeadine GF Gluten-Free Spermidine Supplement

Rated 5.0 stars
5 Reviews

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

Interested in a 3 bottle bundle?  Click here
    • Chlorella
    • Shikuwasa (Citrus Depressa) skin
    • Turmeric root
    • 1.2mg plant-derived spermidine with autophagy enhancer, nobiliten
    • Naturally ocurring source of: vitamin D2, vitamin K, folate, vitamin B12, biotin, pantothenic acid, iron and lutein.
Made in FDA register facility
GMP quality
Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested
logo of a plant
No talc
No shellac

Benefits of our Spermidine Supplement


Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength

Healthy aging

Supports memory, cognition and brain and cardiovascular health


Assists with deeper, sounder sleep and circadian reset


Boosts autophagy, which declines with age, and promotes cellular renewal

Can I just take some chlorella instead of buying this?

There are many different strains and sub-strains of Chlorella, each with their own unique nutritional profile. For instance, some strains of chlorella are high in iodine. Ours is not. Working together with our Japanese partner, we tested these strains of Chlorella looking for significant concentrations of polyamines.

Primeadine GF uses a sub-strain of Chlorella that is uniquely high in spermidine. This needs to be tested for every single batch, because the amount of spermidine varies from batch to batch based on exposure to the sun and other weather conditions.

What are the benefits of taking both?

For those who want to take their autophagy to the next level, we suggest taking Primeadine GF in the morning and original Primeadine in the evening or before bed to help your gut biome produce its own spermidine at night.

How is this different from Primeadine® Original?

Primeadine Original and Primeadine GF are both wholly food-derived with the amount of spermidine, 1mg, that has been used in human clinical trials showing enhancement of memory and cognition. 

Primeadine Original is derived from concentrated, defatted wheat germ and has a small amount (40mg) of gluten. We have been unable to recommend this to clients who are celiac or suffer from Small Intestinal Bacterial Overgrowth (SIBO) or Leaky Gut as a result. 

Because we know that spermidine can be helpful to sealing the gut lining, we wanted to find a source of spermidine that would be suitable for these individuals. 

Primeadine GF contains chlorella which is itself a good source of naturally occurring nutrients, including B vitamins such as folate and B12, as well as iron. These are all important nutrients for women of childbearing age. In addition, for those individuals who are unable to metabolize folic acid, this is a source of bioavailable folate. 

Primeadine GF is a source of vitamins D and K, both of which are needed to drive calcium to the bones. 

In addition, Primeadine GF contains nobiliten, a molecule shown to trigger autophagy and pairs nicely with spermidine. Because spermidine has natural anti-inflammatory properties, we wanted to enhance this even further by adding in some turmeric. 

As a source of polyamines, Primeadine GF contains both spermidine and putrescine, a precursor to spermidine to help your body recycle and manufacture more of its own spermidine.

All our ingredients are sourced and manufactured on the Longevity Blue Zone of Okinawa in Japan in FDA registered facilities and to ISO22000 standards, the highest food grade manufacturing standards that exist. 

Which one should I take?

If you are celiac, have Leaky Gut or SIBO, are on an Autoimmune Paleo or Lectin-free diet, or are gluten sensitive, then Primeadine GF is a good choice for you.

Spermidine inhibits 6 of the 9 Hallmarks of Aging 

Hallmark of Ageing

Rated 5.0 stars
Based on 5 reviews
Total 5 star reviews: 5 Total 4 star reviews: 0 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
100%would recommend this product
5 reviews
  • P
    Verified Reviewer
    I recommend this product
    Age Range 55 - 64
    Gender Female
    Wellness Concern Sleep, Skin Health, Energy levels
    The Pros Science behind the product, Positive results, Clean ingredients
    Rated 5 stars
    1 month ago
    Noticing multiple beneficial effects already.

    I have been taking the daily dose of Primeadine GF for 4 months now and have definitely noticed more than one difference already: my skin has improved (and been complimented on by others), my nighttime hot flushes have stopped so my sleep quality has improved and overall energy levels have increased. Having read the science behind this supplement I am committed to taking this on a long term basis. Would certainly recommend it.

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  • N
    Verified Reviewer
    I recommend this product
    Age Range 45 - 54
    Gender Female
    Wellness Concern Skin Health, Sleep, Hormonal Health, Overall Health, Energy levels
    The Pros Easy to use, Clean ingredients, Speed of action, Science behind the product, Positive results
    Rated 5 stars
    3 months ago

    Have been taking Primeadine for over a month now, my skin, hair texture has improved so much. Feel more energetic and feel great overall. Will definitely be part of my routine from now on.

    Was this helpful?
  • M
    Verified Reviewer
    I recommend this product
    Age Range 35 - 44
    Gender Male
    Wellness Concern Sleep, Energy levels, Overall Health, Aging well
    The Pros Easy to use, Clean ingredients, Speed of action, Positive results, Science behind the product
    Rated 5 stars
    3 months ago
    Deep sleep impact.

    I’ve been struggling with deep sleep for quite some time now, almost a year. My avg was 30mins a night, and being a functional health consultant I tried every tool I had on my belt to sort it but sadly nothing worked. This meant my sleep debt was high, my body was massively under recovered and my gym sessions dropped from 5 days a week to 2 max, I just wasn’t recovering enough. I had the fortune of meeting Leslie and hearing the amazing results others had with primeadine so thought why not try one more thing.

    I’m so glad I did, my deep sleep has increased by 1hr after only 2 weeks. And this one extra hour has been consistent every single night. Some nights it’s higher but never lower. I’m so impressed with this supplement I’m recommending it to all my clients whether they have deep sleep issues or not as sleep is the key to all things health and therefore should be everyone’s first focus on their health journey.

    Thank you Leslie and team for such a fantastic product.

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  • JH
    Jo H.
    Verified Reviewer
    I recommend this product
    Age Range 45 - 54
    Gender Female
    Wellness Concern Sleep, Aging well, Hair loss, Overall Health
    The Pros Speed of action, Science behind the product, Easy to use, Clean ingredients, Positive results
    Rated 5 stars
    4 months ago
    It just gets better!!

    So I had been using the original. Tbh I didn’t think the GF version could be as fabulous as the original but it is. Sleeping score increased once more (as there was a delay stopping the original and starting the gf) hoping my eyelashes stay as long will the gf. So far so good. This has to be my favourite supplement ever. Thankyou Primeadine ❤️

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  • SB
    susan b.
    Verified Buyer
    I recommend this product
    Age Range 65+
    Gender Female
    Wellness Concern Cognition, Aging well, Overall Health, Skin Health
    The Pros Easy to use, Clean ingredients, Speed of action, Science behind the product, Positive results
    Rated 5 stars
    5 months ago
    Good so far

    I have been taking the regular Primeadine supplement for 6 months. It seemed to help a lot with deeper sleep. I just switched over to the GF option a few weeks ago. I have not seen a lapse or disruption in my sleep patterns since switching. If anything, this version might be working a little better. I am not seeing any difference in my hair. Nails are very strong and grow quickly.

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