Rooted in research. Designed for your cells.
Science
Longevity is no longer a mystery. Decades of research have given us a clearer picture than ever of how and why we age, and what we can do to support the process. At Oxford Healthspan, we translate that science into supplements you can trust, built on evidence, made with integrity, and designed to work with your biology, not against it.
Explore the research below.
A molecule your body already makes. And needs more of.
What is spermidine?
Spermidine is a naturally occurring polyamine found in every living cell. Its primary role is to induce autophagy, your body's cellular clean-up and recycling process, through which it is thought to address 9 of the 12 root causes of aging, known as the Hallmarks of Aging.
When you are young, your body produces around two-thirds of its spermidine needs through the gut microbiome and body tissues. The remaining third comes from food. As you age, that internal production declines, making carefully sourced, food-derived supplementation increasingly important for maintaining cellular renewal.
A growing body of evidence. A compelling picture.
What does the science say?
Human studies of spermidine supplementation have shown several encouraging associations, including support for brain and heart health, improved hair growth and fullness, and stronger nails.
A significant body of research in animal models has also pointed to spermidine's potential in healthy aging, longevity, and fertility, offering a meaningful foundation for ongoing human research.
Oxford Healthspan continues to work closely with its scientific advisory board to stay at the forefront of emerging evidence in this field.
One compound. Remarkable reach.
Spermidine & The "Hallmarks Of Aging"
n a landmark paper, Lopez-Otin et al identified 12 biological "hallmarks" that drive how we age. Among them: impaired autophagy, stem cell dysfunction, mitochondrial decline, inflammation, and gut dysbiosis. Spermidine has been associated with supporting all five.
What makes spermidine particularly notable is its breadth. It is one of very few known compounds thought to reduce or reverse the effects of multiple hallmarks simultaneously. Through its induction of autophagy alone, it is thought to influence 9 of the 12.
This is not a single-target intervention. This is cellular renewal at scale.
The discovery that changed how we understand aging.
Autophagy: Nobel Prize Winning Science
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
Science you can trust. Expertise you can verify.
Scientific & Clinical Advisory Board
Our work is guided by an international network of scientific and clinical advisors, many affiliated with the University of Oxford, spanning physiology, immunology, longevity science, and clinical nutrition.
Their involvement ensures that everything we do remains grounded in the latest research and scientific integrity, not in hype, trends, or empty promises.
Professor Denis Noble (University of Oxford)
Emeritus Professor of Physiology and pioneer in systems biology. Co-founder of the Oxford Longevity Project.
Dr. Ghada Alsaleh (University of Oxford)
Researcher in immunology and autophagy that leads the UK's first space innovation lab, with a focus on aging and immune function.
Dr. Katja Simon (Max Delbrück Center, Berlin)
Leads research into autophagy in the immune system, including its role in cellular maintenance.
Dr. Sasi Senga (University of Oxford)
Neurosurgical oncologist and researcher focused on cancer biology.
Dr. Olivia Lesslar (Global)
Celebrity longevity doctor specializing in complex chronic conditions and integrative approaches to health. Featured in NYC Journal's 50 under 50.
Dr. Sandra Kaufmann (Miami)
"Best in medicine" longevity doctor and researcher with a background in cellular biology and aging.
Dr. Paul Ch'en (University of Oxford)
University of Oxford college GP and co-founder of the Oxford Longevity Project, with interests in preventative and holistic care for cancer.
Read More
Amy Lamotte (Hong Kong)
Clinical nutritionist specializing in personalised nutrition and immune health.
Read MoreReferences