Autophagy

The Benefits of Spermidine: A Full Breakdown

The Benefits of Spermidine: A Full Breakdown

Spermidine is revered in the longevity world for its ability to target aging from within by activating cellular renewal (autophagy) and inhibiting the root causes of aging, known as the "Hallmarks of Aging" by scientists.

What are the Benefits of Spermidine?

Most of spermidine’s benefits are linked to its ability to activate autophagy, the body’s natural cellular renewal and cleanup process. By triggering autophagy, spermidine mimics the benefits of fasting by clearing damaged proteins, reducing oxidative stress, and improving mitochondrial function, which in turn supports brain health, heart function, metabolism, and immune strength [1].

Beyond autophagy, spermidine also has direct effects on the hallmarks of aging, including reducing inflammation (inflammaging), preserving telomere length, supporting stem cell function, and protecting DNA integrity [2]. While autophagy is its primary mechanism, these additional effects contribute to enhanced longevity, cognitive resilience, skin and hair health, and overall vitality.

Now, let's dive into how these internal benefits reflect inside and out...

Circadian Rhythm & Sleep Support

Sleep is a critical component of health, and many individuals experience disruptions in their sleep quality as they age. Spermidine has been found to improve sleep and reduce age-related sleep disturbances by modulating some of the clock genes that regulate the circadian rhythm, which is our internal clock [3].

Users of Primeadine® have reported significant improvements in their Deep Sleep and Restfulness scores, as tracked by wearable sleep devices. Better sleep quality translates to improved overall well-being and cognitive function. Check out our 'Testimonials' page to read.

Additionally, you may see an uptick in your Heart Rate Variability (HRV). HRV is a key indicator of nervous system balance, resilience to stress, and overall health. A higher HRV is associated with better sleep and reduced stress.

Energy and Vitality

In addition to enhancing autophagy, spermidine activates mitophagy – a process that clears out old and poorly functioning mitochondria. Mitochondria are the powerhouses of our cells, providing the energy needed for all cellular activities. When mitochondria are not functioning optimally, it can lead to low energy levels. By promoting the renewal of healthy mitochondria, spermidine helps to restore energy and vitality, leading to a renewed sense of stamina and vigor. 

Radiant Wellness

Spermidine supports collagen synthesis, keratin production, and wound healing, promoting healthier, more vital hair, skin, and nails.

In a human clinical trial, it was proven to promote hair growth by moving hair follicles from the shedding phase to the growth phase and keeping them in this phase longer [4, 5]. This is also when melanogenesis, the production of hair pigment, takes place, which is why some of our clients experience hair color repigmentation (however, this is only about 30% of clients as it is down to a variety of factors). Read our blog post on reversing gray hair naturally here.

Memory and Cognition

Cognitive decline is a common concern with aging, but spermidine offers hope in this area as well. By stimulating autophagy, spermidine supports brain health and enhances cognitive function. A human clinical trial found that plant-derived spermidine can improve memory and cognition in older adults experiencing subjective cognitive decline [6]. 

Gut Health

Gut dysbiosis, which is an imbalance between good and bad bacteria in the gut microbiome, is one of the root causes of aging and a key indicator of poor gut health. Spermidine helps to combat this by sealing the tight junctions in the gut lining. Since the gut lining is only one cell thick, these are prone to becoming leaky and require support in sealing them up [7].

Primeadine Original contains a unique prebiotic fiber called FOS that feeds the healthy gut bacteria in the gut microbiome and has been linked to improved brain function in older individuals [8].

Hormonal Balance

Hormonal balance is crucial for maintaining health, especially as we age. Spermidine has been found to positively influence hormone regulation, helping to stabilize levels of key hormones. 

Proven to reduce the stress hormone, cortisol, and increase the hormones that keep you youthful, fertile, and full of energy - progesterone, estradiol, DHEA, and  pregnenolone for women, and testosterone for men - spermidine is a crucial tool for hormonal equilibrium. A recent study also dubbed it “ground-breaking” for the world of fertility, showing it to improve egg quality in older mice through the induction of autophagy [9]. 

Cardiovascular Health

Cardiovascular health is another critical aspect of aging well. Spermidine has been shown to support heart health by improving the function of endothelial cells, which line the blood vessels [10]. This can lead to better blood flow and reduced risk of cardiovascular diseases. Additionally, spermidine's anti-inflammatory properties contribute to a healthier cardiovascular system, helping to maintain optimal heart function and reduce the risk of age-related cardiovascular issues.

Final Thoughts

If you have tried Primeadine for at least 6 months and aren't sure if it's making a difference for you, we'd recommend checking out our blog post on 'How To Optimize Your Results with Primeadine'. 

Since our natural ability to produce spermidine declines with age, we recommend taking Primeadine® on a consistent, long-term basis. Most people can tell a difference after 3-6 months of taking it, but not everyone experiences physical changes.

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Feel free to reach out with any questions or share your success stories with us. We’re here to support you on your journey towards radiant wellness.

 You can find the answers to our most frequently asked questions here.

References

1. Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., … & Fussi, H. (2009). Induction of autophagy by spermidine promotes longevity. Nature cell biology, 11(11), 1305-1314.

2. Lopez-Otin, C., Blasco, M.A., Partridge, L., Serrano, M. & Kroemer, G. (2023) Hallmarks of aging: An expanding universe. Cell, 186(2), 243-278.

3. Zwighaft, Z., Aviram, R., Shalev, M., Rousso-Noori, L., Kraut-Cohen, J.,Golik, M., … & Asher, G. (2015). Circadian clock control by polyamine levels through a mechanism that declines with age. Cell metabolism, 22(5), 874-885.

4. Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study. Dermatology Practical & Conceptual, 7(4), 17.

5. Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., … & Paus, R. (2011). Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLoS One, 6(7), e22564.

6.  Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., …& Flöel, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109, 181-188.

7. Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019). Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in Nutrition, 6, 24.

8. Ni Lochlainn, M., Bowyer, R. C., Moll, J. M., García, M. P., Wadge, S., Baleanu, A., Nessa, A., Sheedy, A., Akdag, G., Hart, D., Raffaele, G., Seed, P. T., Murphy, C., Harridge, S. D., Welch, A. A., Greig, C., Whelan, K., & Steves, C. J. (2024). Effect of gut microbiome modulation on muscle function and cognition: The PROMOTe randomised controlled trial. Nature Communications, 15(1), 1-15. https://doi.org/10.1038/s41467-024-46116-y 

9. Zhang, Y., Bai, J., Cui, Z., Li, Y., Gao, Q., Miao, Y., & Xiong, B. (2023). Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging. Nature Aging, 3(11), 1372-1386. https://doi.org/10.1038/s43587-023-00498-8 

10. de Cabo R, Navas P. Spermidine to the rescue for an aging heart. Nat Med. 2016 Dec 6;22(12):1389-1390. doi: 10.1038/nm.4243. PMID: 27923032; PMCID: PMC5853099.

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