Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.
Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.
Epidemiological studies have correlated higher spermidine levels with longer life.
The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.
As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.
I am intuitively cynical about supplements, but started to take this after I met Leslie at a trade show. I have noticed a big improvement in my toe nails, which of itself makes the product worthwhile. It's not easy to be scientific about the impact on sleep...I would say I sense I am enjoying deeper sleep, though not for longer hours. I feel generally healthy at the best of times. Primaedine intake would seem to have complemented my daytime energy levels. For the toenails alone I would continue to take this.
I must say that Primeadine is the one supplement I have taken over a lifetime of nutrition, exercise and disease preventative living from which I have noticed such a significant improvement to my system and overall health. I consider myself somewhat of a biohacker, and I have experimented with MANY nutritional supplements. After about a month of taking Primeadine, my deep sleep was permanently significantly enhanced, as tracked on my Oura ring. And my hair began to grow faster and thicker, as well as my eyebrows and eyelashes. I am in my early 50's, and my normally grey hair is coming in more brown than grey. It is definitely a peptide I will continue to take indefinitely- well worth the investment! The customer service I received as a result of a delivery issue was prompt, friendly and the company went beyond expectations to make sure I was satisfied. I would highly recommend this quality product and company.
I’m in peri menopause and was starting to have small, but noticeable hot flashes. I started gluten free Primeadine in June and after just one month the hot flashes disappeared. I take 3-5 of the tablets daily at night and can cycle through three bottles quickly. I ran out and got busy and forgot to reorder and for 3 weeks my hot flashes came back but way worse. I was on a work trip to humid, summertime NYC and was dying and thought: is this how it’s gonna be from now on?? I got around to ordering more and doubled up, having 3 tablets blended into my smoothie in the morning and 3-5 at night and, like a miracle, the hot flashes totally disappeared again. Also baby hair is growing in my recessed hairline. It’s a genetic hairline and I wear my hair in pony tails a lot and suddenly I had these whispy “hair horns” on either side of my head. I was like, what tha??? But read hair growth is possible. Definitely working the 3 bottle price tag into my budget.
I’ve only been taking primeadine for a month but have noticed my eye brows and eye lashes are thicker and my sleep has improved. So far very impressed
I am a biohacker, and this is by far my favorite oral supplement. I am 57 years old, and have always had brittle hair and nails. For the first time in my life, I have long, unbreakable nails, and my hair is similarly much stronger. I figure if this stuff is working in such obvious ways, it is probably hitting the mark "under the hood" as well.
I take 3 pills about 30 minutes before bedtime. My holy grail is deep sleep which I monitor with my Oura ring. With Primeadine, I get much more deep sleep - well over an hour. I just went to Maui for two weeks and forgot (perish the thought!) the Primeadine, and watched my deep sleep numbers plummet.
I highly recommend!