Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.
Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.
Epidemiological studies have correlated higher spermidine levels with longer life.
The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.
As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.
I am a biohacker, and this is by far my favorite oral supplement. I am 57 years old, and have always had brittle hair and nails. For the first time in my life, I have long, unbreakable nails, and my hair is similarly much stronger. I figure if this stuff is working in such obvious ways, it is probably hitting the mark "under the hood" as well.
I take 3 pills about 30 minutes before bedtime. My holy grail is deep sleep which I monitor with my Oura ring. With Primeadine, I get much more deep sleep - well over an hour. I just went to Maui for two weeks and forgot (perish the thought!) the Primeadine, and watched my deep sleep numbers plummet.
I highly recommend!
I had been using other spermidine products; mostly by the manufacturer Do Not Age, for about a year prior to trying Primeadine.
Having spent a lot of time outdoors without wearing sunglasses in my youth, I began noticing unsightly pinguecula in both eyes about a year ago. I also noticed Beau's ridges on my thumbnails.
I am on my third month of Primeadine (1 capsule a.m. and 2 p.m.) and the pinguecula is noticeable better, and the Beau's ridges are barely visible. If this could happen after a mere 3 months, I can't wait to see what improvements the next three bring!
I highly recommend this product. I have been taking it for approx 7-8 months and I have noticed so many wonderful benefits. My skin is clearer and fine lines have disappeared, my thinning hair has thickened up and is soft and shiny, my sleep is incredible, no issues waking up between 2-4am anymore and I have amazingly vivid dreams that I recall in the morning. Overall I have more energy and my thinking is clearer, I can walk into a room and remember why I went there! I’m sure it has helped my hormone balance too.
I feel more youthful and so much more positive about my life and future. I have always been fit and healthy and have long taken supplements and practised fasting but I can tell you Primeadine has up levelled all of this and is worth every penny! Autophagy is so important for our cells to renew and regenerate and what better way to aid the process than with spermicide. Ingenious!!
I can’t complete my review without talking about Leslie and her dedication to her products and customers. She has been so helpful and personally answered my email queries and went above and beyond.
Thank you Leslie and Oxford Healthspan for a truly wonderful product!!
I wasn't taking this product for long before I noticed a difference in my sleep, which seemed deeper. I felt more energised as a result. It also improved the way I looked and my eyelashes getting longer were one of the things that happened too. On an intuitive level I felt this to be a good product to take and reading the science behind it proved it.
The brand has the best customer service. It’s refreshing in a world where there’s so much terrible customer service. Thank u!