4.9
Rated 4.9 out of 5 stars
4.9 Stars (33 Reviews)

Primeadine® GF (Gluten-Free)

Sale price$90.00
Sale price Regular price$90.00

SLOW AGING ON A CELLULAR LEVEL

Primeadine® GF is a gluten-free, plant-based spermidine supplement derived from the longevity islands of Okinawa, Japan. Mimics the longevity benefits of fasting, activating cell renewal (autophagy) and targeting key aging pathways.

  • Reduces inflammation, rejuvenates stem cells and mitochondria, and protects telomeres
  • Boosts keratin and collagen production for hair, skin, and nail health
  • Supports circadian rhythm, sleep, energy, hormones, and gut health
$90.00
Delivery Frequency
Flexible subscription plan You can easily manage or cancel your subscription anytime via your account
Free shipping FREE shipping when you order 2 or more bottles
Sale price$90.00
Sale price Regular price$90.00
Sale price Regular price$90.00

Get FREE shipping when you order 2 or more bottles.

American Express Apple Pay Diners ClubDiscoverGoogle Pay MastercardPayPalShop Pay Venmo Visa
Free Shipping Over $100

Purchase two or more bottles for free shipping, including subscriptions.

Plant-Derived

Backed by Science

Pure Ingredients

Third Party Tested

Vegan

Welcome to Your New Prime

As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.

Healthy Aging

Targets the root causes of aging, reducing inflammation, regenerating stem cells and mitochondria, and protecting telomeres.

Radiant Wellness

Supports keratin and collagen production and wound healing, reflecting in a radiant glow and healthier hair and nails.

Restore Balance

Harmonizes your circadian rhythm, gut health, and hormones for improved sleep quality, elevated energy levels, and a clearer mind.

Spermidine Molecule Oxford Healthspan

What is Spermidine?

Spermidine is a naturally occurring polyamine that activates autophagy, the body's process of clearing out and renewing cells, and targets the root causes of aging.

In youth, about two-thirds of spermidine is produced internally, with the rest from food. As production declines with age, dietary and supplemental sources become crucial for maintaining optimal levels.

Learn more

Read Our Testimonials

The Primeadine® Difference

All Natural & Plant-Derived

We opt for food-derived spermidine, the safest and most bioavailable form, and ensure our products are free from unhealthy fillers like magnesium stearate. Additionally, we defat our wheat germ to remove potentially rancid PUFAs (polyunsaturated fatty acids).

Sourced in Japan & Rigorously Third Party Tested

Sourced in Japan, home to the world's longest-lived people and strict food standards, Primeadine® meets the highest ISO2200 quality control. Rigorous third-party testing in Japan and the USA ensures purity and potency.

Optimal Absorption & Results

Food-derived spermidine is better absorbed due to natural co-factors, the food matrix effect, and gut bacteria interactions. Primeadine GF also includes nobiletin and turmeric to further boost autophagy and anti-inflammatory effects.

Recommended by experts

Dr. Olivia Lesslar

@drolivialesslar

Celebrity Anti-Aging Doctor

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, cancer, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Nadine Artemis

@nadineartemisofficial

Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Sandra Kaufmann

@kaufmannantiaging

"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Carol Vorderman

@carolvorders

British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Stephanie Estima

@dr.stephanie.estima

Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou

@hackmyage

Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Dr. Olli Sovijarvi

@ollisovijarvi

Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Magdalena Groselj

@magdalenas_secrets

Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey

@lukestorey

Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam

@nathalieniddam

Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Aneta Grabiec

@anetagrabiec_wellness

Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Learn More on Our Blog

View all
AutophagyNew Spermidine Research Alert!  | Oxford Healthspan

New Research Alert! Further Evidence for Spermidine’s Power to Induce Autophagy

A recent study has added exciting new insights to the ongoing discourse of the potential of spermidine in rectifying dysfunctional autophagy. They looked specifically at two rare cell-trafficking d...

BeautyAchieving Radiant Wellness: Daily Habits for Less Inflammation & More Radiance From a Holistic Beauty Expert

Achieving Radiant Wellness: Daily Habits for Less Inflammation & More Radiance From a Holistic Beauty Expert

In today’s fast-paced world, making time for health and self-care can feel overwhelming. However, wellness doesn’t have to be complicated. Building sustainable habits starts with small, intentional...

DetoxificationLeslie Kenny’s Biohacking Tips for Dry January and Detoxification

Leslie Kenny’s Biohacking Tips for Dry January and Detoxification

Explore the benefits of going alcohol-free with our Founder, Leslie Kenny's, top tips for a healthy Dry January. Optimize your body’s natural detox systems and embrace a vibrant, alcohol-free lifes...