For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.
Primeadine is a pure wholly food-derived spermidine supplement sourced and manufactured in Japan, home to some of the world's longest-lived people. Food-derived spermidine is not only highly bioavailable but unlike synthetic spermidine, it contains two other naturally co-occurring beneficial polyamines, spermine and putrescine, that create a virtuous recycling loop to help your body produce more spermidine.
To complete this loop, we have also added a prebiotic fiber called FOS (fructooligosaccharides) from maltodextrin (beetroot), to feed the spermidine-producing bacteria in your gut biome and promote a balanced gut flora.
PLEASE NOTE: If you have batch number 207, the capsules will be slightly smaller than usual. Other than the size, these capsules are the exact same composition as our original capsules, containing the exact same amount of food-derived spermidine and prebiotic as the larger capsules. Due to customer feedback, we decided to test-run a smaller capsule size (using compression technology.) Unfortunately, we encountered technical problems when we began production at scale. This doesn’t affect the quality or efficacy of these new, smaller capsules, but it does mean it isn’t viable for future manufacturing runs. In the future, we will go back to the original, larger capsule sizes.
Spermidine has been shown to keep hair follicles in the growth phase for longer. Typical results include improved hair growth (including eyelashes and eyebrows), stronger hair and nails and more vital, glowing skin
Spermidine improves healthspan by inhibiting 9 of the 12 hallmarks of aging, including stem cell and mitochondrial dysfunction, telomere shortening, inflammation, and gut dysbiosis. Supports memory, cognition, and heart health
Spermidine supports the regulation of your circadian rhythm, assists with deeper, sounder sleep, and can reduce age-associated sleep disruption
Spermidine and its co-occurring polyamines trigger autophagy, your internal cellular "clean up" and renewal process that declines with age. Your cells are the foundation of every organ and tissue in your body; until they are functioning properly, neither is the rest of you
Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.
The effects of spermidine supplements on humans have been studied and have shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.
Epidemiological studies have correlated higher spermidine levels with longer life.
The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.
As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.
Stem cells lose their ability to divide as we age, and we are unable to replace cells that have migrated, differentiated, or died. As a result, we show outward symptoms of aging, such as gray hair.
As cells age, their mitochondria start to lose their integrity due to the build-up of oxidative stress. Compromised mitochondrial function leads to a number of adverse events, such as increased apoptosis induction, that correlate with aging.
Shortened telomeres are associated with aging cells that are senescent. As cells divide, the telomere ends of chromosomes get shorter. Eventually, telomerase gets silenced and the telomeres are too short for cells to divide.
As cells are exposed to environmental factors, they are subject to changes in their genome through epigenetic mechanisms. Such changes accumulate over time and have been correlated with the decline observed in aging cells.
As cells age, they show an increase in self-preserving signals that result in damage elsewhere. Impaired intercellular communication with aging contributes to decline in tissue health.
As cells age, environmental stresses add up and mechanisms responsible for maintaining proper protein composition start to decline. Proteins lose their stability, autophagic processes start to fail, and misfolded proteins accumulate.
Autophagy is an essential process of removing cellular waste products. It is a component of proteostasis, although now a hallmark in its own right since loss of effective autophagy is a key contributor to the decline of organelle turnover and an accelerator of aging.
Microbes living in and on us are now widely understood to be intricately connected to health and disease. In part due to the gradual decline of our immune system’s effectiveness, and since one of our immune system’s roles is in shaping the diversity and species members of our microbiome, our aging microbiomes gradually lose diversity and become altered in their composition.
“Inflammaging” is a term coined to describe the gradual increase of inflammation as we age. It has wide-ranging implications in disease-related activity such as arteriosclerosis, neuroinflammation, osteoarthritis and bone degradation. Inflammation is also clearly linked to all other hallmarks of aging both in its tendency to promote and result from other hallmarks.
