Clean Living

How to Optimize Your Results with Primeadine®

How to Optimize Your Results with Primeadine®

Primeadine® is a powerful healthy aging tool, restoring balance in the body by increasing levels of the potent polyamine, spermidine. Spermidine has been found to slow aging by targeting its root causes - reducing inflammation, rejuvenating stem cells and mitochondria, and activating cellular renewal.

Without proper cellular renewal, a build-up of cellular debris occurs (think about what happens in your house when you don’t take out the trash for a long time). This affects the functioning of our bodies as a whole, slowing things down and decreasing our energy and vitality as a result.

While spermidine is foundational - our cells affect every part of our bodies! - there could be other things affecting our health. To get the best results from Primeadine®, we recommend thinking about your wellness holistically to ensure nothing is getting in the way of your progress.

Paving the Path to Radiant Wellness

To get the most out of Primeadine®, we need to ensure all aspects of our lifestyle are in harmony.

Daily Movement

Find an exercise you enjoy and stick to it! Consistency is far more important than the type of exercise you do.

One of the reasons Okinawans (residents of the Blue Zone in Okinawa, Japan) are so physically fit is that they get up from a seated position on the floor roughly 100 times a day. This small movement has a significant impact on their musculoskeletal and cardiovascular health.

As well as regular exercise, we recommend squeezing small movements like these into your daily routine - you could start doing plies while you brush your teeth, or sit on the floor while you put your shoes on and try to get up with no support.

Okinawans also walk frequently, with one Japanese study finding that even 7,000 steps a day increased longevity by 20%. 10,000 steps a day may not be achievable for everyone, but 7,000 is enough to make a measurable difference in your health.

Establish A Community

Regular socializing is important to reduce stress and boost endorphins. Even if that means joining a group exercise class or a book club, creating a social space for yourself outside of your family life is a vital component of healthspan and longevity.

Find Your “Ikigai”

Similar to the above, a sense of purpose in life, or “ikigai” in Japan, is a significant factor in happiness and healthspan. Discover how to find your ikigai here. If you know what your ikigai is but don’t have time for it, consider reprioritizing things in your life to fit it in!

Eat A Whole Foods Diet

As a food-derived supplement company, we must remind you that food is medicine and a supplement is not a replacement for a healthy, balanced diet.

No surprises here - the world’s centenarians eat a diet consisting of fresh, organic food and free from inflammatories like vegetable oils, refined sugar, and processed foods.

Everyone is bio-individual and if you find you are experiencing inflammation, you may want to have a think about your diet and if you are consuming any trigger foods. A great book to help you identify and eliminate any triggers is “The Inflammation Spectrum” by Dr. Will Cole.

Check Your Ingredients

Inflammatory triggers are not just in our food, but also our supplements, skincare, and household products. 

Always take a look at the ingredients list (you can use EWG to check their rating based on toxicity) before purchasing as you might be surprised what seemingly "clean" products actually contain.

For example, 'magnesium stearate' - one of the most common fillers used in supplements to bulk out the capsules - might look innocent, since magnesium is an essential nutrient, but it is actually very bad for your health. It has been found to affect nutrient absorption, is typically contaminated with pesticides, and can have a laxative effect. 

If you're looking for a clean skincare company, we love Living Libations by beauty alchemist and author of 'Renegade Beauty', Nadine Artemis. She is also a fan of Primeadine and it is the only product, other than her own, that she endorses!

How do we ensure Primeadine is clean?

Our wholly food-derived ingredients are sourced in Japan, which has the strictest food safety protocol in the world. We then conduct rigorous third party testing in Japan and the USA to ensure the raw ingredients in Primeadine are free from pesticides, herbicides, GMOs, mold, and heavy metals. We also don't add any fillers or flow agents as these do more damage than good. Learn more about our Quality and Testing process here.


Our bodies are made up of roughly 60% water, so we need to keep topping up our supplies by drinking 2-3L of fresh, filtered water daily! This keeps your skin plump and soft and your joints agile.

Manage Your Stress Levels

Another cause of chronic inflammation is stress. Blue Zone centenarians manage their stress much better than we do in the Western world, with regular meditation, mindful eating and the other practices above. 

Optimize Your Sleep

In addition, our efforts are in vain without good sleep, as this is when autophagy - the body's cellular "clean up" and recycling process - takes place for an extended period of time. Here are some tips to optimize your sleep environment:

Your bedroom should be a sanctuary for sleep! To ensure you get enough restorative sleep and Primeadine is able to work its magic, try optimizing your bedroom with these tips:

  • Keep it cool: Aim for a room temperature between 60-67°F (15-19°C).
  • Darken the room: Use blackout curtains or an eye mask to block out light.
  • Reduce noise: Consider earplugs or a white noise machine to drown out disruptive sounds.
  • Choose comfortable bedding: Invest in a good mattress and pillows that support your preferred sleep position.
  • Get in sync with sunlight: Ensure you get daylight exposure in the morning, so your body knows it is the morning.
  • Block out blue light: So your body knows it is the evening, avoid screens at least an hour before bedtime, enable night mode on your devices and/or use blue light-blocking glasses.
  • Watch your caffeine intake: Don't drink caffeine past 5pm and try to limit your intake to 1-2 cups of a caffeinated beverage per day.

        Best Ways to Take Primeadine ®

        Find the Right Dose for You

        If you have tried Primeadine® for a considerable amount of time (say six months) and aren't sure if it's working for you, consider increasing your daily dose. There are no FDA guidelines regarding spermidine consumption, but, the European Food Safety Agency has stated that dosages of up to 6mg of wheatgerm-derived spermidine are considered safe in humans.

        Eat More Spermidine!

        Try to also incorporate more spermidine-rich foods into your diet. This includes foods like shiitake mushrooms, chicken liver, the long fermented soybean dish, natto (if you can stomach it!), green peas, and aged cheeses like mature cheddar and parmasean.

        When to Take it 

        The best times to take Primeadine® are with your first or last meal of the day to either kickstart or extend the autophagy, the body's natural process of cellular renewal, that occurs during your overnight fast. If it's the sleep benefits you are after, we'd recommend taking it before bed.

        If you can tolerate Primeadine with food, you may experiment with taking it on an empty stomach just before bed, or first thing in the morning. However, please note that some people experience digestive discomfort when taking it on an empty stomach, due to the prebiotic content.

        Duration of Use

        Different Factors

        The length of time you should take Primeadine® depends on your age and health status. Younger, healthier individuals might pulse on and off, while older individuals or those with significant health depletions will need continuous use.

        Since we rely on external intake of spermidine as we get older, it’s important to maintain levels long-term through diet and/or supplements. Like vitamin C, our body doesn’t store spermidine from our diet, so we rely on a continuous supply.

        If you need to pause, a break of up to two weeks is generally okay, provided you maintain a diet rich in spermidine during that time. 

        Fast vs Slow Responders

        We recommend giving Primeadine at least six months to notice a difference. While some individuals, who we call "fast responders," might feel changes within the very first week, those with underlying inflammation or other health issues typically respond more slowly as their body uses the spermidine to address these factors first.

        Not sure how to tell if Primeadine® is working for you? Check out our article on what you can expect from Primeadine® here.

        Additional Tips

        Monitor Progress: You might want to consider using a wearable device to track your sleep and HRV improvements. You can also track your biological age (the age of your cells!) with a biological age test, such as GlycanAge.

        Consistency: Regular, daily use is crucial for long-term benefits.

        Final Thoughts

        Every individual’s journey with Primeadine® is unique. If you have specific health concerns or questions, consider consulting with a healthcare provider to tailor your approach. By understanding what to expect and how to optimize your results, you can make the most of Primeadine® and enjoy enhanced well-being and vitality.


        Feel free to reach out with any questions or share your success stories with us. We’re here to support you on your journey towards radiant wellness.

         You can find the answers to our most frequently asked questions here.

        Reading next

        What Can I Expect from Primeadine®? Benefits Timeline
        Skin cell rejuvenation | Oxford Healthspan

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