Fasting

New Research Unveils Spermidine's Vital Role in Fasting-Induced Autophagy & Longevity

New Research Unveils Spermidine's Vital Role in Fasting-Induced Autophagy & Longevity

A groundbreaking study published in Nature Cell Biology in August 2024 reveals that spermidine, a naturally occurring polyamine, is essential for the autophagy (cell renewal) benefits associated with caloric restriction and intermittent fasting.

Spermidine: A Key Player in Cellular Renewal

Researchers from institutions including the University of Graz and the Medical University of Graz discovered that spermidine levels increase during fasting, triggering autophagy - a process where cells remove damaged components and regenerate. This cellular "clean-up" is crucial for maintaining tissue health and function.

The study demonstrated that without sufficient spermidine, fasting-induced autophagy and its associated longevity benefits are significantly diminished. This finding underscores spermidine's pivotal role in the positive effects of fasting. Not only does it mimic fasting itself, but it also improves fasting results!

Implications for Health and Ageing

The research suggests that enhancing spermidine levels could mimic the benefits of fasting, such as improved metabolic health and reduced risk of age-related diseases. This opens avenues for developing spermidine-based interventions to promote healthy aging without the need for strict dietary regimens. See our blog on the implications of fasting on hypothyroidism for more information.

For a deeper dive into the study, you can access the full article here: (nature.com)

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