Primeadine® GF (Gluten-Free) Whole-Food Spermidine Supplement

4.8
Rated 4.8 out of 5 stars
4.8 Stars (41 Reviews)
HEALTHY AGING | CELL HEALTH | RADIANCE

A gluten-free, whole-food spermidine supplement sourced from the longevity islands of Okinawa, Japan. Activates autophagy — the body’s cell renewal process — to promote healthy aging, radiance, and overall wellbeing.

AMOUNT: 60 Day Supply
30 Day Supply60 Day Supply90 Day Supply / Starter Pack180 Day Supply
$180.00
Delivery Frequency
Flexible subscription plan Easily change, pause, or skip your delivery
Easy cancellations Cancel your subscription anytime via your account
Sale price$180.00
Sale price Regular price$180.00
Sale price Regular price$180.00

OR subscribe and save 25% on every order.

American Express Apple Pay BancontactDiners ClubDiscoverGoogle Pay iDEAL WeroMastercardPayPalShop Pay Visa
Get free shipping when you spend over $100

Whole-Food Ingredients

Science-Backed

No Heavy Metals, Pesticides or Fillers/Flow Agents

3rd Party Lab Tested, in Japan & the USA

Vegan

Why customers choose us

The Prime-line: What are the benefits?

Autophagy Oxford Healthspan

Cellular support

Primeadine® GF is designed to support your body’s natural cellular maintenance processes, which play an important role in how we age over time.

Working at a foundational level, it complements your existing lifestyle, supporting the systems involved in energy, resilience, and overall wellbeing.

Visible benefits over time

Because Primeadine® works at a cellular level, changes tend to build gradually.

Many people begin to notice subtle shifts within the first few months, such as improvements in energy, sleep quality, and overall sense of wellbeing. With continued use, visible changes in skin, hair, and nails may also become more noticeable.

If you track your sleep or recovery, you may find it helpful to observe patterns over time

Oxford Healthspan Affiliate Program

Designed for consistency

Natural spermidine levels decline with age, which is why many choose to support their intake consistently over time.

Primeadine® is designed for daily use, where small, steady inputs can contribute to a more considered approach to long-term wellbeing.

The Primeadine® difference

Clean Ingredients from Okinawa

Made with chlorella, turmeric, and lime peel from Okinawa, Japan, Primeadine® GF is fully food-derived, pesticide-free, non-GMO, and grown by local farmers.

Japanese Standards

Sourced in Okinawa, Japan, Primeadine® GF meets ISO22000 standards and is third-party tested in Japan and the USA for purity and potency.

Highly Bioavailable

Food-derived spermidine is delivered alongside its natural co-factors, in a form the body can more easily recognise and utilise.

Primeadine® GF combines whole-food ingredients, including chlorella, citrus peel, and turmeric, to create a more complete and considered formulation.

Recommended by experts

Dr. Olivia Lesslar

@drolivialesslar

Celebrity Anti-Aging Doctor

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, cancer, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Nadine Artemis

@nadineartemisofficial

Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Tim Gray

@timbiohacker

Europe's Leading Biohacker & Founder of the Health Optimisation Summit

Primeadine by Oxford Healthspan is my go-to spermidine supplement. Made with rigorously tested Japan-sourced ingredients and a unique prebiotic to boost gut production, it’s unmatched in quality and effectiveness and doesn't have the nasty additional bulking agents like other brands.

Dr. Sandra Kaufmann

@kaufmannantiaging

"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Dr. Jeff Armstrong

@theagingwellpodcast

Host, Aging Well Podcast and Prof of Exercise Science at Western Oregon University in Portland

I started Primeadine last night. Impatient as I am, I started at 3 capsules. Despite disrupted sleep, I had my best recorded REM sleep (1:35, 24%) and good restorative sleep. I am impressed! My “Biocharge” on my Helio Strap has been low. I was still “low” but significantly improved considering I went to bed at a 5 (drained)… [it] is the highest I have been in a while.

Carol Vorderman

@carolvorders

British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Stephanie Estima

@dr.stephanie.estima

Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou

@hackmyage

Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Dr. Olli Sovijarvi

@ollisovijarvi

Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Magdalena Groselj

@magdalenas_secrets

Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey

@lukestorey

Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam

@nathalieniddam

Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Aneta Grabiec

@anetagrabiec_wellness

Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.