Primeadine® GF (Gluten-Free) Whole-Food Spermidine Supplement
HEALTHY AGING | CELL HEALTH | RADIANCE
A gluten-free, food-derived spermidine supplement sourced from Okinawa, Japan. Formulated to support your body’s natural cellular renewal process called autophagy, helping maintain vitality, radiance, and overall wellbeing.
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Description
Primeadine® GF is a gluten-free, food-derived spermidine supplement sourced from Okinawa, Japan, one of the world’s longest-living populations. It combines a unique blend of naturally occurring compounds from whole foods, including spermidine-rich, iodine-free chlorella, citrus-derived nobiletin, and turmeric.
Together, these ingredients are designed to support the body’s natural cellular renewal processes, including autophagy, which plays a role in maintaining cellular function over time.
Rather than relying on isolated compounds, Primeadine® GF delivers these nutrients in a food-based matrix your body can recognize and utilize more effectively.
Designed to support:
- Healthy aging
Supports normal cellular maintenance and overall wellbeing - Radiance
Helps maintain healthy skin, hair, and nails - Energy and clarity
Supports everyday vitality and cognitive function - Rest and balance
Supports general wellbeing, including sleep and daily rhythm
Ingredients
Primeadine® GF contains a blend of whole-food ingredients from Okinawa:
- Okinawan Chlorella (broken cell wall and iodine-free)
- Shikuwasa Citrus Lime Peel
- Turmeric
Providing naturally occurring:
- Spermidine (1.2mg)
- Lutein (2.57mg)
- Nobiletin (0.3mg)
- Vitamins and minerals including Vitamin D2, Vitamin K, Folate, Vitamin B12, Biotin, and Iron
Other ingredients: Tricalcium Phosphate.
Suggested use
Dosage:
Take 2 tablets daily with water, with your first or last meal.
Getting started:
Begin with 1 tablet on day one. If well tolerated, increase to the full serving.
Tablets may also be crushed and added to smoothies or food if preferred.
Who's it for
- Those taking a proactive approach to long-term health and vitality
- Those looking to support their body’s natural aging processes
- Those seeking a gluten-free, food-derived spermidine supplement
Important information
- If you are taking medication, including blood thinners, consult your healthcare practitioner before use
- If you have a medical condition, consult your healthcare practitioner before use
- Do not use if you are allergic to chlorella, citrus, or turmeric
- Discontinue use if any adverse reaction occurs
Free from
Primeadine® GF is free from:
- Gluten and wheat
- GMOs
- Soy, dairy, and lactose
- Added sugars and artificial additives
- Fillers and flow agents
Each batch is tested for heavy metals, pesticides, and contaminants.
Quality & testing
- Manufactured in GMP-certified facilities
- Produced to ISO22000 food safety standards
- Sourced from Okinawa, Japan
- Third-party tested in both Japan and the USA
- Tested for purity, potency, and contaminants
Primeadine GF Tablets Certification and Testing:
Laboratory: Japan Food Research Laboratories (JFRL)
Lot number: S32066
Laboratory report number: 26035436001-0101
Sample received: 12 June 2026
Certificate issued: 2 July 2026
Independently tested for purity: Every batch of Primeadine GF Tablets (Chlorella, Shikuwasa, and Turmeric) is tested by Japan Food Research Laboratories. These results come from Lot No. S32066, sampled 12 June 2026 and issued 2 July 2026 under report No. 26035436001-0101.
Spermidine content: 130 mg per 100g. Putrescine: 63 mg per 100g. Spermine was not detected.
Heavy metals: tested by Japan Food Research Laboratories. Results fall within limits for food supplements. Full results are in the certificate.
Iron: 24.0 mg per 100g. Vitamin D, Vitamin K, folic acid, pantothenic acid, biotin, and lutein were also tested.
Microbiological safety: aerobic plate count came in at not more than 300 per gram. Escherichia coli, mold, yeast, coagulase-positive staphylococci, and salmonella all tested negative.
Gluten content: tested separately by Delta Labs of South Florida using an ELISA assay, gluten came back below 20 ppm, meeting the threshold for a gluten-free claim under UK and EU food law.
Manufacturer's gluten-free statement: Primeadine GF Tablets are manufactured by Okinawa Ukondo Co., Ltd. at its facility in Ginowan-shi, Okinawa, Japan. The manufacturer has confirmed, in a signed statement dated 9 September 2026, that no gluten-containing ingredients are intentionally added, that the products are made in a gluten-free production area, and that procedures are in place to control and prevent cross-contact with gluten-containing materials. This statement is issued by the manufacturer and does not by itself constitute third-party gluten-free certification.
View the Primeadine GF Tablets Certificate of Analysis
High quality & standards
Primeadine® undergoes rigorous third party testing, both in the Japan (which has the strictest food quality and safety standards in the world) and in the USA. Every batch is tested for heavy metals, mycotoxins, pesticides and herbicides.
- Manufactured in GMP-certified facilities
- Produced to ISO22000 food safety standards
- Sourced from Okinawa, Japan
- Third-party tested in both Japan and the USA
- Tested for purity, potency, and contaminants
View the Primeadine GF Tablets Certificate of Analysis
Why our customers choose us
This product is rated 4.8 of 5.0 stars.
It has received 51 reviews.
Our Founder & CEO, Leslie Kenny
For Leslie Kenny, a Harvard-educated entrepreneur and Oxford-based longevity expert, Oxford Healthspan is not a commercial venture. It is a mission that began with a personal crisis and was answered by science.
Diagnosed with autoimmune conditions in her late 30s and told she could not conceive naturally, Leslie reversed her symptoms through immune modulation and lifestyle changes, and conceived naturally at age 43. That experience became the blueprint for everything Oxford Healthspan stands for: the radical belief that the body, given the right conditions, is capable of extraordinary things.
"Aging well should feel empowering. Primeadine is designed to support a new prime of life."
What is spermidine?
Spermidine is a naturally-occurring molecule found in every living cell. Your body produces it abundantly when you're younger, but levels decline with age, reducing your ability to activate autophagy, your cells' natural renewal and repair process.
Replenishing it through carefully sourced, food-derived supplementation supports the body's natural resilience and vitality over time.
This is not aging interrupted. This is aging activated.
What is autophagy?
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
Why whole-food, not synthetic
Many spermidine supplements use a synthetic form, most often spermidine trihydrochloride, an isolated compound made in a lab. Primeadine GF is made from Okinawan chlorella, citrus lime peel, and turmeric. That means spermidine arrives the way it does in food, alongside its natural companions, the polyamines spermine and putrescine.
You may see supplements with a bigger number on the label. We'd rather be measured by what matters to us: where an ingredient grows, how it's grown, and how carefully every batch is tested.
Backed by Oxford science. Trusted by clinicians.
Our work is guided by an international network of scientific and clinical advisors, many of which are affiliated with the University of Oxford, across physiology, immunology, longevity science, and clinical nutrition.
This ensures our approach remains grounded in the latest research and scientific integrity, not hype and trends.
Prof Denis Noble (University of Oxford)
Emeritus Professor of Physiology and pioneer in systems biology.
Dr. Ghada Alsaleh (University of Oxford)
Researcher in immunology and autophagy, with a focus on aging and immune function.
Dr. Katja Simon (Max Delbrück Center, Berlin)
Leads research into autophagy in the immune system, including its role in cellular maintenance.
Dr. Olivia Lesslar
Celebrity longevity doctor specializing in complex chronic conditions and integrative approaches to health.
Dr. Sandra Kaufmann
"Best in medicine" longevity doctor and researcher with a background in cellular biology and aging.
Dr. Paul Ch'en (University of Oxford)
University of Oxford college GP and co-founder of the Oxford Longevity Project, with interests in preventative and holistic care for cancer.
Amy Lamotte
Clinical nutritionist specializing in personalised nutrition and immune health.
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FAQs
Our Oxford-based customer support team is available Monday to Friday.
Email support@oxfordhealthspan.com or call +1-469-465-8886.
What is spermidine?
Spermidine is a naturally occurring compound known as a polyamine, found in every living cell. It plays a role in supporting the body’s natural cellular maintenance processes, including autophagy, which helps cells renew and function optimally.
While the body can produce spermidine, levels tend to decline with age.
What is autophagy?
Autophagy, from the Greek meaning "self-eating," is the process by which your cells identify, break down, and recycle damaged components. It is one of the body's most elegant and powerful renewal mechanisms, and its role in healthy aging is now firmly established in science.
The discovery of autophagy as a regulated biological process was made by Japanese scientist Yoshinori Ohsumi, whose work earned him the Nobel Prize in Physiology or Medicine in 2016.
Oxford Healthspan is proud to be the only non-Japanese company collaborating with Ohsumi and his team, bringing that pioneering research to the heart of everything we make.
What are the benefits of spermidine?
Spermidine has been studied for its role in supporting cellular health and healthy aging. Research suggests it may contribute to:
- Cellular renewal processes such as autophagy
- Cognitive and cardiovascular health
- Hair, skin, and nail health
- Energy, sleep quality, and overall wellbeing
Many of these effects are linked to its role in supporting the body’s natural maintenance pathways.
Individual experiences vary, but customers often report improvements in energy, sleep, and visible signs of vitality over time.
What's the difference between food-derived and synthetic spermidine?
The key difference lies in how spermidine is delivered and how the body may utilise it.
Food-derived spermidine
Occurs naturally within a whole-food matrix alongside related compounds, including other polyamines such as spermine and putrescine. These naturally co-occurring compounds are part of the body’s polyamine system and may support how spermidine is processed and utilised.
Synthetic spermidine
Is produced in isolation and does not come with this natural matrix. Research into long-term use in humans is still limited compared to food-derived sources.
Why this matters
In whole foods, nutrients exist within a complex structure that can influence absorption and biological activity. Food-derived spermidine reflects this natural context.
What makes Primeadine® superior to other spermidine supplements?
Primeadine® is built around quality, simplicity, and scientific integrity.
- Food-derived spermidine, not synthetically enriched
- Developed alongside scientific advisors, including researchers connected to Oxford
- Third-party tested for purity and potency in both Japan and the USA
- Ingredients sourced from Japan, known for rigorous quality standards
- Free from unnecessary fillers, flow agents, and additives
- Carefully tested for contaminants such as heavy metals and pesticides
Each batch is produced to ensure consistency, purity, and quality.
What is the best spermidine dose to take?
One serving provides 1 mg of food-derived spermidine, consistent with levels used in scientific research.
Individual needs vary. If unsure, consult your healthcare provider before adjusting your intake.
How long does it take to notice results?
Primeadine® works by supporting natural cellular processes, which take time.
While activity begins at a cellular level from the outset, many customers report noticing more meaningful changes after 3 to 6 months of consistent use.
Benefits tend to build gradually with daily use.
What's the difference between Primeadine Original and GF?
Both formulas deliver whole-food spermidine sourced in Japan. They differ in source, dose and what our community mentions most.
Primeadine Original comes from defatted Japanese wheat germ and provides 1mg of spermidine per 3-capsule serving. Customers most often mention hair, skin and nails. It contains a trace of gluten (40mg), so it isn't suitable for anyone with celiac disease or gluten intolerance.
Primeadine GF comes from Okinawan chlorella, with lime peel and turmeric, and provides 1.2mg per 4-tablet serving. It's fully gluten-free, and customers most often mention sleep. It contains iron and vitamin K2, so it isn't suitable for anyone with hemochromatosis or taking blood-thinning medication.
Take either at your first or last meal of the day. If you're unsure, choose based on dietary needs first, then the benefit that matters most to you.