



Primeadine® Original
Activates Cell Renewal | Promotes Longevity | Enhances Sleep & Radiance
A premium, plant-derived spermidine supplement made from concentrated Japanese wheat germ extract. Activates cell renewal (autophagy) and targets aging's root causes, like inflammation, stem cell and mitochondrial dysfunction, and telomere shortening.
Please note, this supplement contains wheat and gluten. Gluten-free alternative here.
This is my 4th month taking Primeadine. There were positive changes in my hair and skin that I noticed surprisingly quickly. I also noticed my sleep improved. I just love knowing that those "accessory upgrades" are just surface proof of the deeper good stuff that's happening in all my other organs and systems. I feel like good stuff is happening - Melissa van P.
Description
Primeadine® Original is a premium, plant-derived spermidine supplement sourced from concentrated and defatted Japanese wheat germ extract. Each dose delivers 1mg of bioavailable spermidine, plus FOS prebiotic fiber to boost natural spermidine production.
Food-derived spermidine promotes your body's vital cellular "clean-up" and recycling system, called autophagy, and targets the root causes of aging. This works to:
- Reduce inflammation, rejuvenates stem cells and mitochondria, and improve telomere length
- Increase keratin production for enhanced hair growth
- Promote collagen synthesis and wound healing for better skin and nails
- Boost energy, memory and cognition
- Support sleep quality, regulates the circadian rhythm, and balances hormonal and gut health
Since our natural ability to produce spermidine declines with age, we recommend taking Primeadine® on a consistent, long-term basis.
Ingredients
Each serving provides 1mg of plant-derived spermidine from concentrated, defatted Japanese wheat* germ extract. Defatting removes omega-6 fatty acids, reducing the risk of rancidity and inflammation.
Other ingredients:
- Prebiotic Fiber (FOS) from Resistant Dextrin (Beetroot).
- Hypromellose (Vegan Cellulose Capsule).
- Sodium Citrate.
*Allergens: Wheat (Contains 40mg of gluten per serving). In comparison, the average slice of bread contains 1,000-2,000mg of gluten, so this is roughly the equivalent of gluten in a crumb of bread.
How to Use
Dosage: 3 capsules per day, taken with water at your first or last meal.
On day one, start with 1 capsule, on day 2, take 2 capsules, and on day 3, take 3 capsules. If well-tolerated, continue at this dose.
Who's It For
- 35+ individuals seeking to improve their longevity, healthspan, and overall wellness.
- Those interested in experiencing the benefits of fasting without dietary restrictions.
- May be suitable for younger individuals who have inflammatory skin conditions, gut health issues, viral overload, or have recently taken antibiotics.
Contraindications
Contains wheat germ, so it's unsuitable for those with Celiac disease or gluten intolerance. Consult your healthcare provider if unsure.
It also contains a prebiotic fiber, which may not be well-tolerated by those with SIBO (small intestinal bacterial overgrowth), IBS (irritable bowel syndrome), or that find it difficult to digest legumes.
For a gluten-free option without added prebiotic fiber, try Primeadine GF.
Allergens: Wheat and gluten.
Free From
- Additives & Processing Agents: Fillers, Binders, Flow Agents
- Allergens & Dietary Concerns: Soy, Lactose, Sugar, PUFAs (polyunsaturated fatty acids)
- Contaminants: Heavy Metals, Pesticides and Herbicides, Mycotoxins
Due to our natural ingredients and absence of binders or fillers, you may notice slight variations in color and density from batch to batch. This variation reflects the purity and cleanliness of our products and is no cause for concern.
Quality & Testing
- Good Manufacturing Practices (GMPs)
- ISO2200 standard, the highest in food quality control
- Sourced in Japan and Made in the USA in FDA-certified facilities
- Rigorous third party testing in Japan and the USA
- Thoroughly tested for heavy metal, contaminant, and microbiological analysis by third party, FDA-registered, ISO-certified laboratories
- Wheat germ is defatted to remove potentially rancid PUFAs (polyunsaturated fatty acids) which, if left in, can cause inflammation in the cells

What are the Benefits?
As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.



Targets the root causes of aging, reducing inflammation, regenerating stem cells and mitochondria, protecting telomeres, and strengthening the gut lining.
Supports keratin and collagen production, improves wound healing, and harmonizes hormonal and gut health. Reflects in a radiant glow and healthier hair and nails.
Brings your circadian rhythm, gut health, and hormones into equilibrium for improved sleep quality, elevated energy levels, and increased focus and cognition.

What is Spermidine?
Spermidine is a natural polyamine that triggers autophagy, the body's cellular clean-up and recycling process, and targets key aging pathways.
In youth, about two-thirds of spermidine is produced by the gut microbiome and body tissues, with the rest coming from food. As we age, natural production declines, making dietary and supplemental sources increasingly important.
Learn moreRead Our Testimonials
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We opt for plant-derived spermidine, the safest, most bioavailable form, and ensure our products are free from unhealthy additives like magnesium stearate. We also defat our wheat germ to remove rancid, inflammation-causing PUFAs.
Sourced in Japan, home to the world's longest-lived people and strict food standards, Primeadine meets the highest ISO2200 quality control. Rigorous third-party testing in Japan and the USA ensures purity and potency.
Food-derived spermidine is better absorbed than synthetic due to natural co-factors that enhance bioavailability, the food matrix effect, and gut bacteria interactions. We also add FOS, a prebiotic fiber, to boost natural production.
Recommended by Experts

@drolivialesslar
Celebrity Anti-Aging Doctor & Psychoneuroimmunologist
Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

@kaufmannantiaging
Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It
There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

@carolvorders
British TV personality & Biohacker
I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

@ollisovijarvi
Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center
My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

@magdalenas_secrets
Biohacker & Anti-Aging Entrepreneur
I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

@lukestorey
Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert
The best spermidine supplement on the market.

@nathalieniddam
Certified Holistic Health Coach & Biohacker
Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

@hackmyage
Gerontologist, Biohacker & Sports Nutrition Coach
I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

@anetagrabiec_wellness
Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert
What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

@silverliberation
Pro-Aging Influencer
One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.
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