the best spermidine in the market

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Primeadine Premium Spermidine Supplement - 90 capsules / 30 day supply

Rated 4.6 stars
94 Reviews

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

    • Primeadine spermidine supplements are wholly food-derived from concentrated wheat germ extract that amounts to 1mg of supplemental spermidine. Defatted to prevent the Omega 6 oils in wheat germ going rancid, and becoming part of your cell membrane.
    • FructoOligoSaccharide/prebiotic (a special resistant starch maltodextrin): acts as a prebiotic fiber that will selectively feed the friendly bacteria in your gut biome, which can produce your own spermidine.
    • Hypromellose (plant cellulose capsule). Vegan.
Made in FDA register facility
GMP quality
Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested
Made in the USA
logo of a plant
No talc
No shellac

Benefits of our Spermidine Supplement


Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength

Healthy aging

Supports memory, cognition and brain and cardiovascular health


Assists with deeper, sounder sleep and circadian reset


Boosts autophagy, which declines with age, and promotes cellular renewal

What is spermidine?

Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

The effects of spermidine supplements on humans have been studied and have shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine inhibits 6 of the 9 Hallmarks of Aging 

Hallmark of Ageing

Rated 4.6 stars
Based on 94 reviews
Total 5 star reviews: 78 Total 4 star reviews: 5 Total 3 star reviews: 4 Total 2 star reviews: 6 Total 1 star reviews: 1
88%would recommend this product
94 reviews
  • MO
    Maria O.
    Verified Reviewer
    I recommend this product
    The Pros Positive results
    Rated 5 stars
    5 hours ago
    Vet amazed at Blood drawn from my Dog

    My dog had recently an eye injury and the vet suggested we did Plasma drops to help recovery. When the blood was drawn and passed on the centrifugation machine, she immediately asked what were we giving our dog due to what she saw. And we’ve been adding 1 capsule of Primeadine Original to her food every single day for over six months!

  • MV
    Melissa van P.
    Verified Buyer
    I recommend this product
    Age Range 45 - 54
    Gender Female
    Wellness Concern Hormonal Health, Energy levels, Cognition, Overall Health, Skin Health
    The Pros Easy to use, Clean ingredients, Speed of action, Science behind the product, Positive results
    Rated 5 stars
    21 hours ago
    So great!

    This is my 4th month in now taking Primeadine. There were positive changes in my hair and skin that I noticed surprisingly quickly. I also noticed my sleep improved. I just love knowing that those "accessory upgrades" are just surface proof of the deeper good stuff that's happening in all my other organs and systems. I feel like good stuff is happening.

  • B
    Verified Buyer
    I recommend this product
    The Pros Positive results
    Rated 5 stars
    1 week ago
    Better sleep

    I have only been taking for a month but have noticed a huge improvement in my sleep quality. I am looking forward to seeing added benefits with longer term use! I did not have any of the GI symptoms new users report.

  • J
    Verified Reviewer
    I do not recommend this product
    Age Range 55 - 64
    Gender Female
    Wellness Concern Hair loss, Aging well
    Rated 2 stars
    1 week ago
    Just not sure yet

    I expected to see better hair but haven't gotten there yet. Might be sleeping better but I don't know that it's really any different. I'm hoping it's doing great things inside that I can't quite see yet.

  • MM
    Michele M.
    Verified Reviewer
    I recommend this product
    Age Range 45 - 54
    Gender Female
    Wellness Concern Hair loss, Sleep, Energy levels, Hormonal Health
    The Pros Easy to use, Clean ingredients, Science behind the product, Positive results
    Rated 5 stars
    1 week ago
    30 Day Review of Primeadine

    I have just finished my first bottle of Primeadine and my hair has benefitted immensely from this supplement. I have very fine, thin hair and after 30 days it feels lovely and thicker than normal. My sleep has also improved since taking this product. I will definitely continue to take Primeadine for a few more months to see what else this super supplement does for me!

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