the best spermidine in the market


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Primeadine Spermidine Supplement 3-month Supply

Rated 4.4 stars
26 Reviews

For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.

    • Concentrated wheat germ extract containing 1mg of supplemental, exogenous spermidine. Defatted to prevent the oils in wheat germ from going rancid.
    • Maltodextrin (FOS/prebiotic): acts as a prebiotic fiber and resistant starch that will selectively feed the fuso- and bacterioides bacteria in your gut biome, both of which produce spermidine. This is to support your gut biome's own ability to produce its own spermidine.
    • Hypromellose (plant cellulose capsule). Vegan.
Made in FDA register facility
GMP quality
Japan Health and Nutrition Food Association JHNFA JHFA logo
Lab tested
Made in the USA
logo of a plant
No talc
No shellac

Benefits of our Spermidine Supplement


Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength

Healthy aging

Supports memory, cognition and brain and cardiovascular health


Assists with deeper, sounder sleep and circadian reset


Boosts autophagy, which declines with age, and promotes cellular renewal

What is spermidine?

Spermidine is a potent polyamine, known for inducing autophagy, which is the body's cellular renewal and recycling process that slows as we age.

Supplementation with spermidine in humans has been shown to support cognition and heart health, promote hormonal balance and improve hair growth and fullness (including eyelashes and eyebrows), and strengthen nails.

Epidemiological studies have correlated higher spermidine levels with longer life.

The gut biome and our tissues produce 2/3 of our body's spermidine. This is known as 'endogenous production'. The final third comes 'exogenously' or externally from our diet.

As we age, spermidine production in our tissues and gut biome begins to fall, reducing autophagy, and therefore cell renewal.

Spermidine inhibits 6 of the 9 Hallmarks of Aging 

Hallmark of Ageing

Rated 4.4 stars
Based on 26 reviews
Total 5 star reviews: 18 Total 4 star reviews: 4 Total 3 star reviews: 2 Total 2 star reviews: 1 Total 1 star reviews: 1
85%would recommend this product
26 reviews
  • B
    Verified Buyer
    I recommend this product
    The Pros Easy to use, Science behind the product, Positive results, Clean ingredients
    Rated 5 stars
    1 month ago
    I Was Surprised

    I bought this to help with inflammation from rheumatoid arthritis. It seems to be aiding this to some extent, but it's tricky to tell since my symptoms tend to come and go. However, now that I am on my fourth bottle, I've definitely noticed healthier hair growth, more hair fullness, and my sleep has improved tremendously. Finally some help with this that doesn't involve medications or supplements that lead to that morning after hangover of grogginess. I have not experienced any side effects from this supplement (I take the full dose each morning after breakfast). I plan to keep using this.

  • A
    Verified Buyer
    I recommend this product
    Age Range 45 - 54
    Gender Male
    Wellness Concern Hormonal Health, Hair loss, Aging well
    The Pros Easy to use, Clean ingredients, Positive results, Science behind the product
    Rated 5 stars
    6 months ago
    Impressive so far

    Sometimes it's hard to tell if you're imagining things that you want to happen, or if they are actually happening. I've tried many avenues to improve hair growth and arrest hair loss and graying hair. I considered all factors which could have contributed to my situation. I have been listening to Leslie and all her advice and considerations for hair loss and re-growth and graying hair. Spermidine was the most interesting thing I had heard about from her, and some of the stories she mentioned about people re-growing hair and with colour were pretty fascinating. So I have been using the spermidine for 3 months. The first month I noticed nothing significant. In the second month I noticed the quality of my hair was more lustrous and I was losing less hair, so I felt. In the third month i noticed that I was definitely not losing as much hair. My hair is behaving more the way I used to remember it, curly and with more life. Woth respect to graying hair, it appears to be helping with stopping the graying on my facial hair and perhaps starting to get more colour as well. So, so far very impressive. I will continue to take it indefinitely. Thank you Leslie for being the most sensible person out there researching this topic and finding the most pertinent advice and solutions.

  • MP
    Miriam P.
    Verified Buyer
    I recommend this product
    Age Range 45 - 54
    Gender Female
    Wellness Concern Sleep, Aches & Pains of Aging
    The Pros Easy to use, Clean ingredients, Positive results
    Rated 5 stars
    9 months ago

    i feel good

  • JProfile picture for Jesse
    Verified Buyer
    I do not recommend this product
    Age Range 35 - 44
    Gender Female
    Wellness Concern Sleep, Energy levels, Cognition, Aging well, Overall Health
    The Pros Science behind the product
    Rated 3 stars
    9 months ago
    The research is all there, but…

    I didn’t really notice any change. Doesn’t mean it isn’t working, but I just didn’t notice any changes.

    Also, one facet I didn’t like about Primeadine is how difficult it is to swallow the pills. The coating seems extra thick and feels more difficult to get down. I really wish I could give 5 stars because I believe in the research, but I simply did not notice any improvement.

  • MS
    Miriam S.
    Verified Buyer
    I recommend this product
    Age Range 55 - 64
    Gender Female
    Wellness Concern Hair loss, Skin Health, Aging well
    The Pros Positive results, Science behind the product, Speed of action, Clean ingredients, Easy to use
    Rated 5 stars
    9 months ago
    My hair, skin and nails have improved dramatically!

    Since using Primeadine, my hair has gotten thicker and I even have dark hairs growing in with my gray. Fingernails that have been split and cracked for years are finally growing out healthy and strong, and my skin tone has brightened and improved. Friends and family have noticed the changes. I have recommended this product many times.

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