Made from concentrated & defatted Japanese wheat germ extract
Each serving contains 1mg of supplemental spermidine
Supports natural spermidine production with added prebiotic fiber
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Vegan & cruelty free
Rated 4.9 out of 5 stars
99 Reviews

Primeadine® Original Spermidine Supplement - 1 Bottle / 30 Day Supply

Sale price$90.00
Sale price Regular price$90.00

I just love knowing that those "accessory upgrades" are just surface proof of the deeper good stuff that's happening in all my other organs and systems.
- Melissa

Primeadine® Original is a wholly plant-derived spermidine supplement for healthy aging and activating cellular renewal, or autophagy. Each serving provides 1mg of the purest, most bioavailable spermidine from concentrated and defatted Japanese wheat germ extract.

  • Supports sleep quality and circadian rhythm
  • Enhances hair growth
  • Supports skin and nail health
  • Promotes energy and vitality
  • Helps maintain gut health
Delivery Frequency
Flexible subscription plan Change, pause or skip your delivery
Easy cancellations You can manage or cancel your subscription online
Sale price$90.00
Sale price Regular price$90.00
Sale price Regular price$90.00

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Wholly food-derived
Free shipping when you subscribe or on orders over $100
Made from concentrated & defatted Japanese wheat germ extract
Each serving contains 1mg of supplemental spermidine
Supports natural spermidine production with added prebiotic fiber
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Vegan & cruelty free

Customer & Expert Reviews

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Celebrity Anti-Aging Doctor & Psychoneuroimmunologist

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Dr Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

What Is Spermidine?

Spermidine is a potent plant-derived polyamine found to increase longevity and healthspan. It does this by addressing the root causes of aging and activating your body's cellular renewal process, called autophagy.

Spermidine is found in all living things, but is most concentrated in sperm (hence the name!), breast milk, and the endosperm of seeds, such as wheat germ. We naturally produce spermidine, but our ability to do so declines with age, impacting our ability to trigger autophagy also. This increases our dietary needs for spermidine and is where food-derived, supplemental sources of spermidine come in handy.

Learn More

Primeadine® vs other Spermidine Supplements

What makes Primeadine® the best spermidine supplement out there?




100% plant-derived, not synthetic



Contains other beneficial, naturally-co-occurring polyamines, spermine & putrescine



Endorsed by Oxford University scientists & doctors



Improves natural spermidine production



Sourced & made in Japan



When Can I Expect Results?

1-4 weeks

If you have a wearable sleep tracking device, look to see if there are any changes to your sleep scores within your first week of taking Primeadine. If not, try taking it right before bed! After at least 2 weeks, you may notice you need to clip your nails sooner than expected. This is a sign of increased cell turnover. This cellular renewal will also be happening in your hair and skin.

4-12 weeks

Changes to your hair may be noticeable after 6-8 weeks (around the time you get your hair cut next). The human clinical trial done on food-derived spermidine found improvements to cognition within 12 weeks.

12+ weeks

We recommend taking Primeadine continuously to experience the full range of benefits from enhanced cellular renewal and addressing the root causes of aging.

How to Take

Serving size

Serving size is 3 capsules per day with liquid at mealtime.

First time use

First time taking Primeadine® Original? We recommend tapering up to the full dose over 3 consecutive days. On Day 1, take 1 capsule, on Day 2, take 2 capsules, on Day 3, take 3 capsules.

Long term use

Going forward, we suggest taking Primeadine® with liquid at your last meal to kickstart autophagy before bed, or with liquid at breakfast to extend the benefits of your overnight fast.

Key Ingredients

✔️ Made in a FDA Registered Facility
✔️ Lab Tested
✔️ Vegan & Cruelty Free

Concentrated & Defatted Japanese Wheat Germ Extract

Plant-derived spermidine and its naturally co-occurring, beneficial polyamines, putrescine and spermine, are found in wheat germ in abundance, but not all wheat germ is created equal. We source a high-potency wheat germ extract from Japan, home to some of the world's longest lived people and meticulous food safety and quality standards. We then defat the wheat germ to ensure the omega 6 fatty acids in it do not go rancid, which can cause inflammation, and to make it more easily absorbable by your gut biome.

FOS (fructooligosaccharide)

The added prebiotic fiber, FOS (frutooligiosaccharide), in Primeadine® Original selectively feeds the spermidine-producing bacteria in your gut biome, supporting your body's natural production of spermidine. It also feeds the other friendly bacteria in the gut, promoting a healthy gut flora. This unique prebiotic is found in maltodextrin, which we derive from beetroot.


Have a question? Curious to learn more? The answers to our most commonly asked questions are below.

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