The power of both Primeadine Original & GF
Vegan & cruelty free
Supports natural spermidine production
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Rigorous 3rd party testing

Primeadine® Original & GF Spermidine Supplement Mixed Bundle - 180 Day Supply

Sale price$486.00 Regular price$540.00

Experience the unique benefits of both Primeadine® Original and Primeadine® GF with our mixed bundle.

  • Promotes longevity and cellular renewal (autophagy)
  • Mimics the benefits of fasting
  • Supports sleep quality and circadian rhythm
  • Enhances hair growth

*Contains a 180 day supply of Primeadine, including 3 bottles of Original and 3 bottles of GF.

American Express Apple Pay Diners ClubDiscoverMeta Pay Google Pay MastercardPayPalShop Pay Venmo Visa
Wholly food-derived
Rigorous third party testing
The power of both Primeadine Original & GF
Vegan & cruelty free
Supports natural spermidine production
ISO22000 standard, the highest in food quality control
No synthetics, fillers, flow agents, GMOs, pesticides, heavy metals, or PUFAs
Rigorous 3rd party testing

Read Our Testimonials

Recommended by Experts

Dr. Sandra Kaufmann


Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Celebrity Anti-Aging Doctor & Psychoneuroimmunologist

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

Dr Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Japan Wheat Oxford Healthspan

What is Spermidine?

Spermidine is a potent plant-derived compound found to increase longevity and healthspan. It does this by addressing the root causes of aging and activating your body's cellular renewal process, called autophagy, which declines with age.

We naturally produce spermidine, but our ability to do so declines with age, increasing our dietary needs.

Learn More

Primeadine® vs other Spermidine Supplements

What makes Primeadine® the best spermidine supplement out there?




Wholly plant-derived, no synthetics



No fillers, flow agents, pesticides, heavy metals, PUFAs, or GMOs



Endorsed by leading longevity scientists & doctors



Supports natural spermidine production



ISO22000 standard, the highest in food quality control



When can I Expect Results?

1-4 weeks

If you have a wearable sleep tracking device, check if there are any changes to your sleep scores within your first week of taking Primeadine. If not, try taking it right before bed! After at least 2 weeks, you may notice you need to clip your nails sooner than expected. This is a sign of increased cell turnover, which will also be happening in your hair and skin.

4-12 weeks

Changes to your hair may be noticeable after 6-8 weeks (around the time you get your hair cut next). The human clinical trial done on food-derived spermidine found improvements to cognition within 12 weeks.

12+ weeks

We recommend taking Primeadine continuously to experience the full range of benefits from enhanced cellular renewal and addressing the root causes of aging.

How to Take

Serving size

Serving size is 3 capsules per day (Original) or 2 tablets per day (GF) with liquid at mealtime.

First time use

We recommend tapering up to the full dose over 3 days (for Primeadine Original) or two days (for Primeadine GF).

Long term use

We suggest taking Primeadine® Original with liquid at breakfast to extend the benefits of your overnight fast, and Primeadine® GF with liquid at your last meal to kickstart autophagy before bed.


Have a question? Curious to learn more? The answers to our most commonly asked questions are below.

Our customer support team is available Monday to Friday, 9am to 5:30pm UK time.Average answer time: 24h
Contact Us