Enter Your New Prime With Primeadine® Spermidine

Primeadine® encapsulates Japan's best-kept healthy aging secret - a potent polyamine called spermidine shown to slow aging and increase healthspan on a cellular level. Redefine how you age with the cleanest, most bioavailable plant-derived spermidine supplement from Japan.


Customer & Expert Reviews

Dr. Sandra Kaufmann


"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol: Why We Age and How to Stop It

There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

Nadine Artemis


Beauty Philosophist, Author & Founder of Living Libations

My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

Dr. Olivia Lesslar


Medical Doctor with a Special Interest in Longevity & Complex Conditions

Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients. 

Carol Vorderman


British TV personality & Biohacker

I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

Luke Storey


Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert

The best spermidine supplement on the market.

Magdalena Groselj


Biohacker & Anti-Aging Entrepreneur

I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

Dr. Stephanie Estima


Women’s Health Expert & Author of “The Betty Body”

My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

Zora Benhamou


Gerontologist, Biohacker & Sports Nutrition Coach

I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

Nathalie Niddam | Oxford Healthspan

Nathalie Niddam


Certified Holistic Health Coach & Biohacker

Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.

Dr. Olli Sovijarvi


Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor & CEO of Biohacking Center

My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

The top longevity supplement for gray hair, hair loss, and anti-aging. I've been taking this for two months and I've already noticed less hair shedding. Eyelashes look longer and stronger, my skin is brighter and I'm getting much more deep sleep.

Aneta Grabiec


Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert

What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

How Can Primeadine® Support You?

Healthy Aging

Plant-derived spermidine has been shown to increase longevity and healthspan by addressing the root causes of aging, known as the "Hallmarks of Aging". These include gut dysbiosis, inflammation, and stem cell and mitochondrial dysfunction. One of the most important hallmarks spermidine helps with is impaired autophagy (cellular renewal), as this effects them all!

Enhanced Cell renewal

Plant-derived spermidine triggers autophagy, your body's internal cellular recycling and "clean up" process that declines with age. Your cells are foundational to every part of your body; if they're not functioning and regenerating properly, neither will the rest of you.

Sleep quality & CIRCADIAN RHYTHM

Plant-derived spermidine has been found to improve sleep quality and reduce age-associated sleep and circadian rhythm disruption. Have a wearable sleep-tracking device? Many of our clients see their Deep Sleep & Restfulness scores shoot up after taking Primeadine®.

Energy & vitality

In addition to triggering autophagy (cellular renewal), plant-derived spermidine has been found to activate a cellular process known as mitophagy, which clears out the old and poorly functioning mitochondria. Because the mitochondria provide energy to your cells, when they aren't functioning well you may experience low energy as a result. Reenergize your mitochondria and experience a renewed sense of energy and stamina.

Healthy Hair, skin & nails

Plant-derived spermidine has been shown to improve hair growth by moving hair follicles from the shedding phase to the growth phase and keeps them there for longer. It is in this phase that melanogenesis (hair color pigmentation) takes place. Spermidine also promotes strong, healthy nails and bright, glowing skin. Welcome to your New Prime!

Brain health, memory & cognition

Spermidine supports brain health by triggering cellular renewal, or autophagy. Clinical trials have found plant-derived spermidine to improve memory and cognition in older adults with subjective cognitive decline. Brain fog be gone!

gut health

Gut dysbiosis is one of the root causes of aging, and spermidine may reduce this by sealing the tight junctions in the gut lining that are prone to becoming leaky. As a bonus, both Primeadine® Original and GF contain prebiotics, promoting healthy digestion and gut microbial balance.

Heart health

Plant-derived spermidine has been found to promote healthy cardiovascular function. One of the ways it does this is by increasing nitric oxide production (AKA blood flow!)

What Makes Primeadine® Unique?

Wholly Plant-Derived

Unlike synthetic and synthetically-enriched spermidine, Primeadine® contains wholly plant-derived spermidine - the only kind to be tested for safety and efficacy in humans - at the minimum effective dose of 1mg as used in clinical trials. With Primeadine®, it's about quality over quantity.

The Cleanest Ingredients

We source and manufacture Primeadine® in Japan, known for its superior food quality and safety standards, and perform rigorous 3rd party testing to ensure purity and potency. Primeadine® is completely free of hidden impurities like heavy metals, mycotoxins, pesticides, and PUFAs, and additives like fillers and flow agents.

Supports Natural Production

Other beneficial polyamines naturally occur with plant-derived spermidine: spermine, for DNA methylation, and putrescine, a precursor to spermidine and spermine that helps your body make more of both. We also add a special prebiotic fiber to Primeadine® Original that supports spermidine production in your gut biome.

What Is Spermidine?

Spermidine is a potent, naturally-occurring molecule found to increase lifespan and healthspan by tackling the root causes of aging and activating your body’s cellular “clean up” process, called autophagy.

Spermidine is found in all cells, but is most abundant in sperm (hence the name!) and breast milk, speaking to how vital it is to all human life. We naturally produce it and get it from our diets. However, our ability to produce it declines with age, making us much more reliant on plant-based, supplemental sources of spermidine, like Primeadine®.

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Primeadine® vs Other Spermidine Supplements




Wholly plant-derived, no synthetics



No fillers, flow agents, pesticides, heavy metals, toxins, PUFAs, and GMOs



Endorsed by leading longevity scientists & doctors



Supports natural spermidine production



ISO22000 standard, the highest in food quality control



Backed by Leading Longevity Experts

Our products are formulated with the oversight of internationally recognized longevity scientists and doctors, including Oxford University Emeritus Professor of Physiology, Denis Noble and Immunology Professor and Autophagy Expert, Katja Simon, "Best in Medicine" Longevity Doctor and Author of ‘The Kaufmann Anti-Aging Protocol’, Dr. Sandy Kaufmann, Celebrity Anti-Aging Doctor and Psychoneuroimmunologist, Dr. Olivia Lesslar, and Head of the UK's first-of-its-kind Space Innovation Lab and Autophagy Researcher, Dr. Ghada Alsaleh, among others.

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About Our Founder, Leslie Kenny

Oxford Healthspan was founded by Leslie Kenny, an Oxford-based, Southern Californian entrepreneur whose life changed dramatically when she was diagnosed with a string of autoimmune diseases - lupus, rheumatoid arthritis and hypothyroidism - in her 30s and told they could only be managed, not cured, with strong immunosuppressants. On a quest to heal herself, she trained as a health coach and her career took an interesting turn, seeing her help scientists at top-tier universities find funding for their ground-breaking discoveries. This is when a little-known longevity molecule, spermidine, was brought to her attention by an Oxford University scientist, and the rest is history.

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