



Primeadine® GF (Gluten-Free)
Activates Cell Renewal | Promotes Longevity | Enhances Sleep & Radiance
A gluten-free, plant-derived spermidine supplement sourced from the longevity islands of Okinawa, Japan. Activates cell renewal (autophagy) and targets aging's root causes, like inflammation, stem cell and mitochondrial dysfunction, and telomere shortening.
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"I have been taking Primeadine for 5 months and have noticed my menstrual cycle regulate, improved sleep, major hair growth! No Fall seasonal shed like I usual experience. Skin tone is better and brighter. It’s really amazing! Thank you Leslie and Oxford Healthspan for this wonderful supplement!" - Stephanie B.
Description
Primeadine® GF harnesses the power of 3 potent autophagy activators and anti-inflammatories—spermidine (Okinawan chlorella), nobiletin (Okinawan citrus peel), and curcumin (Okinawan turmeric)—from Okinawa, Japan.
Food-derived spermidine promotes a vital cellular "clean-up" and recycling system, called autophagy and targets the root causes of aging. This works to:
- Reduce inflammation, rejuvenate stem cells and mitochondria, and improve telomere length
- Increase keratin production for enhanced hair growth
- Promote collagen synthesis and wound healing for better skin and nails
- Boost energy, memory and cognition
- Support sleep quality, regulate the circadian rhythm, and balance hormonal and gut health
Since our natural ability to produce spermidine declines with age, we recommend taking Primeadine® on a consistent, long-term basis.
Ingredients
Primeadine® GF contains Okinawan Chlorella (whole, broken cell wall), Shikuwasa Citrus Peel, and Turmeric, providing naturally-occurring:
- Spermidine (1.6mg)
- Lutein (2.57mg) – has been shown to reduce glare and protect the eye from sun damage
- Nobiletin (0.3mg)
- Vitamins and Minerals: Vitamin D2 (7mcg), Vitamin K (6mcg), Folate (25mcg), Vitamin B12 (0.09mcg), Biotin (3mcg), Pantothenic Acid (0.04mg), and Iron (0.3mg).
Other Ingredients: Tricalcium Phosphate.
How to Use
Dosage: 2 tablets per day, with water at your first or last meal. You may also grind tablets and add to smoothies.
First Time Use: On your first day, take 1 tablet and if well-tolerated, continue with the recommended dose.
Who's It For
- 35+ individuals seeking to improve their longevity, healthspan, and overall wellness.
- Those interested in experiencing the benefits of fasting without dietary restrictions.
- May be suitable for younger individuals who have inflammatory skin conditions, gut health issues, viral overload, or have recently take antibiotics.
- Vegetarians and vegan women who still have their monthly cycles are especially prone to low iron and lower levels of vitamin B12, so Primeadine GF may be helpful in these situations.
Contraindications
- The formula contains natural Vitamin K2, a coagulating agent, so avoid it with blood thinners.
- If you have hemochromatosis, consult your healthcare provider due to the iron content.
- Do not take if allergic to chlorella, citrus, or turmeric. Discontinue use if you experience any negative reactions.
Free From
- Additives & Processing Agents: Fillers, Binders, Flow Agents
- Allergens & Dietary Concerns: Wheat, Gluten, GMOs, Soy, Lactose, Sugar, PUFAs (polyunsaturated fatty acids)
- Contaminants: Heavy Metals, Pesticides and Herbicides, Mycotoxins
Primeadine® GF is made in an FDA-registered facility, in Okinawa, Japan, that does NOT handle wheat, shellfish, dairy, or nuts.
To maintain product purity, we limit the use of binders, which may cause natural splitting and color variation between batches. This variation reflects the purity and cleanliness of our products and is no cause for concern.
Quality & Testing
- Good Manufacturing Practices (GMPs)
- ISO2200 standard, the highest in food quality control
- Sourced in Japan and Made in the USA in FDA-certified facilities
- Rigorous third party testing in Japan and the USA
- Thoroughly tested for heavy metal, contaminant, and microbiological analysis by third party, FDA-registered, ISO-certified laboratories

What are the Benefits?
As cell renewal increases and balance is restored, expect newfound vitality, wellness, and vibrancy.



Targets the root causes of aging, reducing inflammation, regenerating stem cells and mitochondria, protecting telomeres, and strengthening the gut lining.
Supports keratin and collagen production, improves wound healing, and harmonizes hormonal and gut health. Reflects in a radiant glow and healthier hair and nails.
Brings your circadian rhythm, gut health, and hormones into equilibrium for improved sleep quality, elevated energy levels, and increased focus and cognition.

What is Spermidine?
Spermidine is a natural polyamine that triggers autophagy, the body's cellular clean-up and recycling process, and targets key aging pathways.
In youth, about two-thirds of spermidine is produced by the gut microbiome and body tissues, with the rest coming from food. As we age, natural production declines, making dietary and supplemental sources increasingly important.
Learn moreRead Our Testimonials
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The raw ingredients in Primeadine GF—chlorella, turmeric, and citrus lime peel—are fully food-derived and sourced from Okinawa, Japan. Chlorella is grown in freshwater ponds, while the turmeric and lime are pesticide-free and farmed by local, independent growers.
Sourced in Okinawa, Japan, home to the world's longest-lived people and strict food standards, Primeadine meets the highest ISO2200 quality control. Rigorous third-party testing in Japan and the USA ensures purity and potency.
Food-derived spermidine is better absorbed than synthetic due to natural co-factors that enhance bioavailability, the food matrix effect, and gut bacteria interactions. The citrus lime peel also contains nobiletin, another autophagy activator to enhance effects, and the turmeric provides additional anti-inflammatory benefits.
Recommended by experts

@drolivialesslar
Celebrity Anti-Aging Doctor
Primeadine is an exceptional quality spermidine that I use in many protocols, especially when I am trying to induce autophagy. These include such diverse protocols as those for tinnitus, cancer, post-viral syndromes, 'autoimmunity', and graying hair! I am especially pleased to have a gluten-free version to offer patients.

@nadineartemisofficial
Beauty Philosophist, Author & Founder of Living Libations
My renegade beauty secret for deeper sleep, stronger nails, longer lashes, fuller hair, smoother skin, and fading freckles.

@kaufmannantiaging
"Best in Medicine" Longevity Doctor & Author of The Kaufmann Protocol
There is no question that spermidine is a crucial component to any longevity program. Thankfully, Oxford Healthspan offers an unparalleled product line. The quality is unprecedented, derived from naturally-sourced materials and manufactured in Japan. As a result, the products contain not only spermidine, but related polyamines which provide additional health benefits. As a result, I highly recommend this product line to all of my patients.

@carolvorders
British TV personality & Biohacker
I’m nearly 62, and I started looking into lowering my biological age. Primeadine supplements really help with, fundamentally, what’s called autophagy, which is getting rid of rubbish in your cells and using it for energy and for cell renewal and for your brain as well. Lots of you ask about what I take and this is a key essential.

@dr.stephanie.estima
Women’s Health Expert & Author of “The Betty Body”
My hair was starting to go from gray back to […] dark brown. It was gray, and now it’s back to its original color. When I think about spermidine as a whole, the way I am viewing it is as a way to reduce systemic inflammation.

@hackmyage
Gerontologist, Biohacker & Sports Nutrition Coach
I’ve been taking Primeadine spermidine on and off for about 3 years. Every time I go on it, my sleep or recovery scores on my tracking devices go up. And when I go off of it, after several weeks they start to drop.

@ollisovijarvi
Pioneer of Holistic & Preventive Medicine in Finland & Medical Doctor
My wife has been taking it for six months and I think she looks younger and her hair growth has come back after pregnancy, and nails, and all kinds of things that are a reflection of good vitality.

@magdalenas_secrets
Biohacker & Anti-Aging Entrepreneur
I’ve noticed (via the Oura ring app) my deep and REM sleep improved enormously! My nails are so firm and my skin is even more beautiful and glowing. If you want to improve your health and rejuvenate your body, I suggest following an anti-aging protocol with Primeadine.

@lukestorey
Writer, Meditation & Metaphysics Teacher & Lifestyle Design Expert
The best spermidine supplement on the market.

@nathalieniddam
Certified Holistic Health Coach & Biohacker
Primeadine upregulates autophagy and mitophagy, helps the immune system to rejuvenate plus it protects DNA and supports deep sleep, hair skin, and nails. It’s a staple in my supplement stack!

@anetagrabiec_wellness
Psychologist, Nutritional Therapist & Hormonal Wellbeing Expert
What I noticed is: incredibly thick and fast-growing eyelashes, hair, and nails; improved skin texture; constant energy levels; great digestion; stronger immunity; deep, restful sleep; balanced hormones and regular menstruation.

@silverliberation
Pro-Aging Influencer
One of my non-negotiable supplements for better skin, hair, lash growth, and autophagy. And best of all - improved sleep.
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