For Canadian Customers: due to customs processing and overall transit times, please allow at least 10-15 business days for your order to arrive.
Primeadine GF, our soy-free, gluten-free spermidine supplement exclusively sourced and manufactured in the Longevity islands of Okinawa, is our answer for clients who are Celiac or suffer from Small Intestinal Bacterial Overgrowth (SIBO) or Leaky Gut, or simply want to avoid all sources of gluten in their diets. It is manufactured in a manufacturing facility that does NOT handle wheat, nuts, dairy or shellfish.
Primeadine GF is wholly food-derived with the amount of spermidine, 1mg, that has been used in human clinical trials showing enhancement of memory and cognition.
As a source of polyamines, Primeadine GF contains both spermidine and putrescine, a precursor to spermidine to help your body recycle and manufacture more of its own spermidine, sparing your body’s own reserves of l-arginine, l-ornithine, and SAM-e.
Primeadine GF contains two anti-inflammatories, spermidine and turmeric, and two autophagy stimulators, spermidine, and nobiletin, along with naturally occurring vitamin D, K, folate, B12, and iron. Suitable for vegans and vegetarians.
Take two tablets with 8oz/250ml of water to ensure you are adequately hydrated. You may also chew the tablets (please drink water afterwards) or grind them and add to a smoothie.
Enhances hair growth, fullness, shine and texture including eyelashes and eyebrows, and promotes nail growth and strength
Supports memory, cognition and brain and cardiovascular health
Assists with deeper, sounder sleep and circadian reset
Boosts autophagy, which declines with age, and promotes cellular renewal
There are many different strains and sub-strains of Chlorella, each with their own unique nutritional profile. For instance, some strains of chlorella are high in iodine. Ours is not. Working together with our Japanese partner, we tested these strains of Chlorella looking for significant concentrations of polyamines.
Primeadine GF uses a sub-strain of Chlorella that is uniquely high in spermidine. This needs to be tested for every single batch, because the amount of spermidine varies from batch to batch based on exposure to the sun and other weather conditions.
For those who want to take their autophagy to the next level, we suggest taking Primeadine GF in the morning and original Primeadine in the evening or before bed to help your gut biome produce its own spermidine at night.
Primeadine Original and Primeadine GF are both wholly food-derived with the amount of spermidine, 1mg, that has been used in human clinical trials showing enhancement of memory and cognition.
Primeadine Original is derived from concentrated, defatted wheat germ and has a small amount (40mg) of gluten. We have been unable to recommend this to clients who are celiac or suffer from Small Intestinal Bacterial Overgrowth (SIBO) or Leaky Gut as a result.
Because we know that spermidine can be helpful to sealing the gut lining, we wanted to find a source of spermidine that would be suitable for these individuals.
Primeadine GF contains chlorella which is itself a good source of naturally occurring nutrients, including B vitamins such as folate and B12, as well as iron. These are all important nutrients for women of childbearing age. In addition, for those individuals who are unable to metabolize folic acid, this is a source of bioavailable folate.
Primeadine GF is a source of vitamins D and K, both of which are needed to drive calcium to the bones.
In addition, Primeadine GF contains nobiliten, a molecule shown to trigger autophagy and pairs nicely with spermidine. Because spermidine has natural anti-inflammatory properties, we wanted to enhance this even further by adding in some turmeric.
As a source of polyamines, Primeadine GF contains both spermidine and putrescine, a precursor to spermidine to help your body recycle and manufacture more of its own spermidine.
All our ingredients are sourced and manufactured on the Longevity Blue Zone of Okinawa in Japan in FDA registered facilities and to ISO22000 standards, the highest food grade manufacturing standards that exist.
If you are celiac, have Leaky Gut or SIBO, are on an Autoimmune Paleo or Lectin-free diet, or are gluten sensitive, then Primeadine GF is a good choice for you.
Stem cells lose their ability to divide as we age, and we are unable to replace cells that have migrated, differentiated, or died. As a result, we show outward symptoms of aging, such as gray hair.
As cells age, their mitochondria start to lose their integrity due to the build-up of oxidative stress. Compromised mitochondrial function leads to a number of adverse events, such as increased apoptosis induction, that correlate with aging.
Shortened telomeres are associated with aging cells that are senescent. As cells divide, the telomere ends of chromosomes get shorter. Eventually, telomerase gets silenced and the telomeres are too short for cells to divide.
As cells are exposed to environmental factors, they are subject to changes in their genome through epigenetic mechanisms. Such changes accumulate over time and have been correlated with the decline observed in aging cells.
As cells age, they show an increase in self-preserving signals that result in damage elsewhere. Impaired intercellular communication with aging contributes to decline in tissue health.
As cells age, environmental stresses add up and mechanisms responsible for maintaining proper protein composition start to decline. Proteins lose their stability, autophagic processes start to fail, and misfolded proteins accumulate.
Autophagy is an essential process of removing cellular waste products. It is a component of proteostasis, although now a hallmark in its own right since loss of effective autophagy is a key contributor to the decline of organelle turnover and an accelerator of aging.
Microbes living in and on us are now widely understood to be intricately connected to health and disease. In part due to the gradual decline of our immune system’s effectiveness, and since one of our immune system’s roles is in shaping the diversity and species members of our microbiome, our aging microbiomes gradually lose diversity and become altered in their composition.
“Inflammaging” is a term coined to describe the gradual increase of inflammation as we age. It has wide-ranging implications in disease-related activity such as arteriosclerosis, neuroinflammation, osteoarthritis and bone degradation. Inflammation is also clearly linked to all other hallmarks of aging both in its tendency to promote and result from other hallmarks.
