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Loss of Proteostasis: Hallmark of Aging #4
To function, proteins need to be folded perfectly. And, for our bodies to function, we need this process to be conserved and protected: Proteins are responsible for nearly every task in our body in...

Epigenetic Alterations: Hallmark of Aging #3
Some epigenetic changes are predictable - for example, many of the changes associated with lifestyle factors. But some epigenetic changes are random and associated with many diseases and risk fact...

Telomere Attrition: Hallmark of Aging #2
In the last blog post discussing Hallmark #1, we talked a lot about how DNA damage accompanies aging. A particular brand of DNA damage is telomere attrition or loss, the second hallmark.

Genomic Instability: Hallmark of Aging #1
This month we shine the spotlight on the first hallmark of aging, genomic instability or genomic damage.

The Hallmarks of Aging: A Guide to the Pathways of Aging [Updated: 2023]
Today we’re talking about the hallmarks of aging. No, we’re not talking about the visual signals like gray hair, wrinkles, or failing eyes. Why don’t we stay forever cherubic? You may be more under...

Spermidine, a Calorie Restriction Mimetic for Longevity
Sadly, there’s no quick fix for the effects of aging or the extra pounds that sometimes (and so easily) sneak onto our waistlines. But, there is a simple behavior that can combat time (yes, really)...