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In a landmark paper published in Cell (that’s a really good one) in 2013, Lopez-Otin et al set forth nine hallmarks of aging. And, the paper has been cited thousands of times without real refutation. To be named a hallmark, it fulfills (to varying the degrees) the following three criteria:
Science-backed
Rigorous 3rd party testing
No talc
No shellac
No PUFAs